Výsledky vyhledávání - "Jennifer M. Lu-Kuo"

Post-transcriptional Stabilization by Interleukin-1β of Interleukin-6 mRNA Induced by c-kit Ligand and Interleukin-10 in Mouse Bone Marrow-derived Mast Cells

Autor: Howard R. Katz, K. Frank Austen, Jennifer M. Lu-Kuo

Publikováno v: Journal of Biological Chemistry. 271:22169-22174

We demostrate that a specific combination of cytokines elicits high levels of interleukin (IL)-6 gene expression in mast cells and define the cellular mechanisms of the exogenous cytokine action. The addition of c-kit ligand (KL) and IL-10 to IL-3-de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2cacaf4867106c453dfd1b6fbf4d74
https://doi.org/10.1074/jbc.271.36.22169

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Impaired kit- but not FcepsilonRI-initiated mast cell activation in the absence of phosphoinositide 3-kinase p85alpha gene products

Autor: David M. Joyal, Howard R. Katz, Jennifer M. Lu-Kuo, Lewis C. Cantley, David A. Fruman

Publikováno v: The Journal of biological chemistry. 275(8)

The class I(A) phosphoinositide 3-kinases (PI3Ks) consist of a 110-kDa catalytic domain and a regulatory subunit encoded by the p85alpha, p85beta, or p55gamma genes. We have determined the effects of disrupting the p85alpha gene on the responses of m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63eba548aec3edc6918ed656e3a64d60
https://pubmed.ncbi.nlm.nih.gov/10681597

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gp49B1 inhibits IgE-initiated mast cell activation through both immunoreceptor tyrosine-based inhibitory motifs, recruitment of src homology 2 domain-containing phosphatase-1, and suppression of early and late calcium mobilization

Autor: Jennifer M. Lu-Kuo, D M Joyal, Howard R. Katz, K F Austen

Publikováno v: The Journal of biological chemistry. 274(9)

We define by molecular, pharmacologic, and physiologic approaches the proximal mechanism by which the immunoglobulin superfamily member gp49B1 inhibits mast cell activation mediated by the high affinity Fc receptor for IgE (FcepsilonRI). In rat basop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b0a02fcfec2d90b6d4fd31c5767bd9b
https://pubmed.ncbi.nlm.nih.gov/10026201

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527 Impaird Kit- but not Fc?RI-mediated mast cell activation in the absence of regulatory subunits encoded by the phosphoinositide 3-kinase (PI3K) p85? gene

Autor: Lewis C. Cantley, David A. Fruman, Jennifer M. Lu-Kuo, Howard R. Katz

Publikováno v: Journal of Allergy and Clinical Immunology. 105:S174

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2bb1d448b69d44ccea44443b1670c017
https://doi.org/10.1016/s0091-6749(00)90955-2

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