Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jennifer M. Hayashi"'
Autor:
Camille R. Simoneau, Pei-Yi Chen, Galen K. Xing, Jennifer M. Hayashi, Irene P. Chen, Mir M. Khalid, Nathan L. Meyers, Taha Y. Taha, Kristoffer E. Leon, Rahul K. Suryawanshi, Maria McCavitt-Malvido, Tal Ashuach, Krystal A. Fontaine, Lauren Rodriguez, Bastian Joehnk, Keith Walcott, Sreelakshmi Vasudevan, Xiaohui Fang, Mazharul Maishan, Shawn Schultz, Jeroen P. Roose, Michael A. Matthay, Anita Sil, Mehrdad Arjomandi, Nir Yosef, Melanie Ott
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract As SARS-CoV-2 continues to spread worldwide, tractable primary airway cell models that recapitulate the cell-intrinsic response to arising viral variants are needed. Here we describe an adult stem cell-derived human airway organoid model ove
Externí odkaz:
https://doaj.org/article/2b9300e935d0405aa6dbdcaf44fa0f99
Autor:
Taha Y. Taha, Irene P. Chen, Jennifer M. Hayashi, Takako Tabata, Keith Walcott, Gabriella R. Kimmerly, Abdullah M. Syed, Alison Ciling, Rahul K. Suryawanshi, Hannah S. Martin, Bryan H. Bach, Chia-Lin Tsou, Mauricio Montano, Mir M. Khalid, Bharath K. Sreekumar, G. Renuka Kumar, Stacia Wyman, Jennifer A. Doudna, Melanie Ott
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Although the SARS-CoV-2 Omicron variant (BA.1) spread rapidly across the world and effectively evaded immune responses, its viral fitness in cell and animal models was reduced. The precise nature of this attenuation remains unknown as genera
Externí odkaz:
https://doaj.org/article/49493a60ddbb416184e22cc9169a5aac
Autor:
Yusuke Matsui, Lin Li, Mary Prahl, Arianna G. Cassidy, Nida Ozarslan, Yarden Golan, Veronica J. Gonzalez, Christine Y. Lin, Unurzul Jigmeddagva, Megan A. Chidboy, Mauricio Montano, Taha Y. Taha, Mir M. Khalid, Bharath Sreekumar, Jennifer M. Hayashi, Pei-Yi Chen, G. Renuka Kumar, Lakshmi Warrier, Alan H.B. Wu, Dongli Song, Priya Jegatheesan, Daljeet S. Rai, Balaji Govindaswami, Jordan Needens, Monica Rincon, Leslie Myatt, Ifeyinwa V. Asiodu, Valerie J. Flaherman, Yalda Afshar, Vanessa L. Jacoby, Amy P. Murtha, Joshua F. Robinson, Melanie Ott, Warner C. Greene, Stephanie L. Gaw
Publikováno v:
JCI Insight, Vol 7, Iss 12 (2022)
Pregnancy confers unique immune responses to infection and vaccination across gestation. To date, there are limited data comparing vaccine- and infection-induced neutralizing Abs (nAbs) against COVID-19 variants in mothers during pregnancy. We analyz
Externí odkaz:
https://doaj.org/article/e263e98537e14ce58365d0a07e07c9dc
Autor:
Jennifer M. Hayashi, Kirill Richardson, Emily S. Melzer, Steven J. Sandler, Bree B. Aldridge, M. Sloan Siegrist, Yasu S. Morita
Publikováno v:
mBio, Vol 9, Iss 1 (2018)
ABSTRACT Cell elongation occurs primarily at the mycobacterial cell poles, but the molecular mechanisms governing this spatial regulation remain elusive. We recently reported the presence of an intracellular membrane domain (IMD) that was spatially s
Externí odkaz:
https://doaj.org/article/d4024532b5e649359bab4c5e0edff90c
Autor:
Marius Walter, Irene P Chen, Albert Vallejo-Gracia, Ik-Jung Kim, Olga Bielska, Victor L Lam, Jennifer M Hayashi, Andrew Cruz, Samah Shah, Frank W Soveg, John D Gross, Nevan J Krogan, Keith R Jerome, Birgit Schilling, Melanie Ott, Eric Verdin
Publikováno v:
PLoS Pathogens, Vol 18, Iss 9, p e1010811 (2022)
SARS-CoV-2 non-structural protein Nsp14 is a highly conserved enzyme necessary for viral replication. Nsp14 forms a stable complex with non-structural protein Nsp10 and exhibits exoribonuclease and N7-methyltransferase activities. Protein-interactome
Externí odkaz:
https://doaj.org/article/19538024418c4582aee777208e569149
Autor:
Abdullah M. Syed, Irene P. Chen, Jennifer M. Hayashi, Mir M. Khalid, Katarzyna M. Soczek, Jennifer A. Doudna, Taha Y. Taha, Melanie Ott, Alison Ciling, Takako Tabata, Bharath Sreekumar, Pei-Yi Chen
Publikováno v:
Science. 374:1626-1632
A tool to probe SARS-CoV-2 biology To develop therapies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and emerging variants, it is important to understand the viral biology and the effect of mutations. However, this is challeng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e697019a5b82f36cc6673b2e968cd020
https://doi.org/10.1126/science.abl6184
https://doi.org/10.1126/science.abl6184
Autor:
Camille R. Simoneau, Pei-Yi Chen, Galen K. Xing, Mir M. Khalid, Nathan L. Meyers, Jennifer M. Hayashi, Taha Y. Taha, Kristoffer E. Leon, Tal Ashuach, Krystal A. Fontaine, Lauren Rodriguez, Bastian Joehnk, Keith Walcott, Sreelakshmi Vasudevan, Xiaohui Fang, Mazharul Maishan, Shawn Schultz, Jeroen Roose, Michael A. Matthay, Anita Sil, Mehrdad Arjomandi, Nir Yosef, Melanie Ott
As SARS-CoV-2 continues to spread worldwide, tractable primary airway cell models that accurately recapitulate the cell-intrinsic response to arising viral variants are needed. Here we describe an adult stem cell-derived human airway organoid model o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052c9a607750875ea4cae9034f85ba7f
https://doi.org/10.1101/2022.08.02.502100
https://doi.org/10.1101/2022.08.02.502100
Autor:
Irene P. Chen, James E. Longbotham, Sarah McMahon, Rahul K. Suryawanshi, Mir M. Khalid, Taha Y. Taha, Takako Tabata, Jennifer M. Hayashi, Frank W. Soveg, Jared Carlson-Stevermer, Meghna Gupta, Meng Yao Zhang, Victor L. Lam, Yang Li, Zanlin Yu, Erron W. Titus, Amy Diallo, Jennifer Oki, Kevin Holden, Nevan Krogan, Danica Galonić Fujimori, Melanie Ott
Publikováno v:
Cell reports, vol 40, iss 3
bioRxiv
bioRxiv
Inhibitors of bromodomain and extraterminal domain (BET) proteins are possible anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) prophylactics as they downregulate angiotensin-converting enzyme 2 (ACE2). Here we show that BET proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5372b20c38023d14b59bc671f5a2a48
https://escholarship.org/uc/item/2pf842c8
https://escholarship.org/uc/item/2pf842c8
Autor:
Julia Puffal, Ian L. Sparks, James R. Brenner, Xuni Li, John D. Leszyk, Jennifer M. Hayashi, Scott A. Shaffer, Yasu S. Morita
The intracellular membrane domain (IMD) is a metabolically active and laterally discrete membrane domain initially discovered in Mycobacterium smegmatis. The IMD correlates both temporally and spatially with the polar cell envelope elongation in M. s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ee86b74292f0ae6b9248ce6b7c3b5e7
https://doi.org/10.1101/2022.01.07.475471
https://doi.org/10.1101/2022.01.07.475471
Autor:
Yusuke Matsui, Lin Li, Mary Prahl, Arianna G. Cassidy, Nida Ozarslan, Yarden Golan, Veronica J. Gonzalez, Christine Y. Lin, Unurzul Jigmeddagva, Megan A. Chidboy, Mauricio Montano, Taha Y. Taha, Mir M. Khalid, Bharath Sreekumar, Jennifer M. Hayashi, Pei-Yi Chen, G. Renuka Kumar, Lakshmi Warrier, Alan H.B. Wu, Dongli Song, Priya Jegatheesan, Daljeet S. Rai, Balaji Govindaswami, Jordan Needens, Monica Rincon, Leslie Myatt, Ifeyinwa V. Asiodu, Valerie J. Flaherman, Yalda Afshar, Vanessa L. Jacoby, Amy P. Murtha, Joshua F. Robinson, Melanie Ott, Warner C. Greene, Stephanie L. Gaw
Pregnancy confers unique immune responses to infection and vaccination across gestation. To date, there is limited data comparing vaccine versus infection-induced nAb to COVID-19 variants in mothers during pregnancy. We analyzed paired maternal and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4300e56534842400121e14e63d96d34
https://doi.org/10.1101/2021.12.09.21267557
https://doi.org/10.1101/2021.12.09.21267557