Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jennifer M. Bratt"'
Autor:
Angela Linderholm, Nicholas J. Kenyon, Erin O’Roark, Vivian W. Kwan, Jennifer M. Bratt, Michael Last
Publikováno v:
Pharmaceuticals, Vol 4, Iss 1, Pp 187-201 (2011)
L-Arginine, the amino acid substrate for nitric oxide synthase, has been tested as a therapeutic intervention in a variety of chronic diseases and is commonly used as a nutritional supplement. In this study, we hypothesized that a subset of moderate
Externí odkaz:
https://doaj.org/article/0284270ca25e47d390c12eba9c57c4b2
Autor:
Jennifer M. Bratt, Keisha Williams, Michelle F. Rabowsky, Michael S. Last, Lisa M. Franzi, Jerold A. Last, Nicholas J. Kenyon
Publikováno v:
Mediators of Inflammation, Vol 2010 (2010)
Objectives and Design. The function of the airway nitric oxide synthase (NOS) isoforms and the lung cell types responsible for its production are not fully understood. We hypothesized that NO homeostasis in the airway is important to control inflamma
Externí odkaz:
https://doaj.org/article/a014cc152eca4e2dac3eecdf4680cdf6
Autor:
Jennifer M. Bratt, Kevin Y. Chang, Michelle Rabowsky, Lisa M. Franzi, Sean P. Ott, Simone Filosto, Tzipora Goldkorn, Muhammad Arif, Jerold A. Last, Nicholas J. Kenyon, Amir A. Zeki
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950), vol 200, iss 11
Bratt, JM; Chang, KY; Rabowsky, M; Franzi, LM; Ott, SP; Filosto, S; et al.(2018). Farnesyltransferase inhibition exacerbates eosinophilic inflammation and airway hyperreactivity in mice with experimental asthma: The complex roles of ras GTPase and farnesylpyrophosphate in type 2 allergic inflammation. Journal of Immunology, 200(11), 3840-3856. doi: 10.4049/jimmunol.1601317. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/9fx6h3fj
Bratt, JM; Chang, KY; Rabowsky, M; Franzi, LM; Ott, SP; Filosto, S; et al.(2018). Farnesyltransferase inhibition exacerbates eosinophilic inflammation and airway hyperreactivity in mice with experimental asthma: The complex roles of ras GTPase and farnesylpyrophosphate in type 2 allergic inflammation. Journal of Immunology, 200(11), 3840-3856. doi: 10.4049/jimmunol.1601317. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/9fx6h3fj
Copyright © 2018 by The American Association of Immunologists, Inc. All right reserved. Ras, a small GTPase protein, is thought to mediate Th2-dependent eosinophilic inflammation in asthma. Ras requires cell membrane association for its biological a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4426185443c6f3ab9c0bf29f96eaa707
https://escholarship.org/uc/item/9fx6h3fj
https://escholarship.org/uc/item/9fx6h3fj
Autor:
Jun Yang, Sung Hee Hwang, Jennifer M. Bratt, Guodong Zhang, Keisha Williams, Christoph F.A. Vogel, Amir A. Zeki, Lisa M. Franzi, Hua Dong, Nicholas J. Kenyon, Yanping Lin, Jun-Yan Liu, Bruce D. Hammock
Publikováno v:
American journal of respiratory cell and molecular biology, vol 52, iss 1
Control of airway inflammation is critical in asthma treatment. Soluble epoxide hydrolase (sEH) has recently been demonstrated as a novel therapeutic target for treating inflammation, including lung inflammation. We hypothesized that pharmacological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df925069a19a6cadf47fa745052da59
https://doi.org/10.1165/rcmb.2013-0440oc
https://doi.org/10.1165/rcmb.2013-0440oc
Autor:
Angela L. Linderholm, Jennifer M. Bratt, Amir A. Zeki, Gertrud U. Schuster, Nicholas J. Kenyon
Publikováno v:
Immunology and allergy clinics of North America, vol 34, iss 4
Asthma is a complex syndrome that affects an estimated 26 million people in the United States but gaps exist in the recognition and management of asthmatic subgroups. In this manuscript, we propose alternative approaches for future treatments of adul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ce368ea251804972927bded01bf10b
https://doi.org/10.1016/j.iac.2014.07.006
https://doi.org/10.1016/j.iac.2014.07.006
Publikováno v:
Journal of Asthma and Allergy
Tan, LD; Bratt, JM; Godor, D; Louie, S; & Kenyon, NJ. (2016). Benralizumab: A unique IL-5 inhibitor for severe asthma. Journal of Asthma and Allergy, 9, 71-81. doi: 10.2147/JAA.S78049. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/4w7302z0
Tan, LD; Bratt, JM; Godor, D; Louie, S; & Kenyon, NJ. (2016). Benralizumab: A unique IL-5 inhibitor for severe asthma. Journal of Asthma and Allergy, 9, 71-81. doi: 10.2147/JAA.S78049. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/4w7302z0
© 2016 Tan et al. The presence of eosinophilic inflammation is a characteristic feature of chronic and acute inflammation in asthma. An estimated 5%-10% of the 300 million people worldwide who suffer from asthma have a severe form. Patients with eos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e9a6a2704c548733e0cf71bd91debe
https://escholarship.org/uc/item/4w7302z0
https://escholarship.org/uc/item/4w7302z0
Autor:
Benjamin B. Davis, Tzipora Goldkorn, Simone Filosto, Lei Wang, Jennifer M. Bratt, Kent E. Pinkerton, Nicholas J. Kenyon, Amir A. Zeki, William F. Walby, Edward S. Schelegle
Publikováno v:
European Respiratory Journal. 42:350-361
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death. The statin drugs may have therapeutic potential in respiratory diseases such as COPD, but whether they prevent bronchial epithelial injury is unknown. We hypothesised t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aff967981d4d60d280337498a5993f0a
https://doi.org/10.1183/09031936.00042512
https://doi.org/10.1183/09031936.00042512
Publikováno v:
Toxicology and Applied Pharmacology. 257:182-188
The mechanistic basis of the high toxicity to lung macrophages of coarse PM from the California wildfires of 2008 was examined in cell culture experiments with mouse macrophages. Wildfire PM directly killed macrophages very rapidly in cell culture at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::898433f82ebe4803db7bbd671ca3771d
https://doi.org/10.1016/j.taap.2011.09.003
https://doi.org/10.1016/j.taap.2011.09.003
Publikováno v:
Bratt, JM; Zeki, AA; Last, JA; & Kenyon, NJ. (2011). Competitive metabolism of L-arginine: Arginase as a therapeutic target in asthma. Journal of Biomedical Research, 25(5), 299-308. doi: 10.1016/S1674-8301(11)60041-9. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/11q6626k
Journal of Biomedical Research
Journal of Biomedical Research
Exhaled breath nitric oxide (NO) is an accepted asthma biomarker. Lung concentrations of NO and its amino acid precursor, L-arginine, are regulated by the relative expressions of the NO synthase (NOS) and arginase iso-forms. Increased expression of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c549c1885dce63cf1623e9e98eb463f9
https://doi.org/10.1016/s1674-8301(11)60041-9
https://doi.org/10.1016/s1674-8301(11)60041-9
Publikováno v:
Translational Research. 156:335-349
Airway remodeling in asthma contributes to airway hyperreactivity, loss of lung function, and persistent symptoms. Current therapies do not adequately treat the structural airway changes associated with asthma. The statins are cholesterol-lowering dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f4e37b12a4468893652961e696cd5d9
https://doi.org/10.1016/j.trsl.2010.09.003
https://doi.org/10.1016/j.trsl.2010.09.003