Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jennifer M. Ashe"'
Autor:
François Van Laethem, Ingrid Saba, Jinghua Lu, Abhisek Bhattacharya, Xuguang Tai, Terry I. Guinter, Britta Engelhardt, Amala Alag, Mirelle Rojano, Jennifer M. Ashe, Ken-ichi Hanada, James C. Yang, Peter D. Sun, Alfred Singer
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
MHC-independent αβTCRs (TCRs) recognize conformational epitopes on native self-proteins and arise in mice lacking both MHC and CD4/CD8 coreceptor proteins. Although naturally generated in the thymus, these TCRs resemble re-engineered therapeutic ch
Externí odkaz:
https://doaj.org/article/8782eccbbb154dcb86bc5b3f712336d7
Autor:
Terry I. Guinter, Mirelle Rojano, Britta Engelhardt, Ingrid Saba, James Chih-Hsin Yang, Abhisek Bhattacharya, Jinghua Lu, Ken-ichi Hanada, Amala Alag, Alfred Singer, François Van Laethem, Peter D. Sun, Jennifer M. Ashe, Xuguang Tai
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)
Van Laethem, François; Saba, Ingrid; Lu, Jinghua; Bhattacharya, Abhisek; Tai, Xuguang; Guinter, Terry I; Engelhardt, Britta; Alag, Amala; Rojano, Mirelle; Ashe, Jennifer M; Hanada, Ken-Ichi; Yang, James C; Sun, Peter D; Singer, Alfred (2020). Novel MHC-Independent αβTCRs Specific for CD48, CD102, and CD155 Self-Proteins and Their Selection in the Thymus. Frontiers in immunology, 11, p. 1216. Frontiers Research Foundation 10.3389/fimmu.2020.01216
Frontiers in Immunology, Vol 11 (2020)
Van Laethem, François; Saba, Ingrid; Lu, Jinghua; Bhattacharya, Abhisek; Tai, Xuguang; Guinter, Terry I; Engelhardt, Britta; Alag, Amala; Rojano, Mirelle; Ashe, Jennifer M; Hanada, Ken-Ichi; Yang, James C; Sun, Peter D; Singer, Alfred (2020). Novel MHC-Independent αβTCRs Specific for CD48, CD102, and CD155 Self-Proteins and Their Selection in the Thymus. Frontiers in immunology, 11, p. 1216. Frontiers Research Foundation 10.3389/fimmu.2020.01216
MHC-independent αβTCRs (TCRs) recognize conformational epitopes on native self-proteins and arise in mice lacking both MHC and CD4/CD8 coreceptor proteins. Although naturally generated in the thymus, these TCRs resemble re-engineered therapeutic ch
Publikováno v:
The Journal of Experimental Medicine
As a result of interaction with epithelial cells in the thymic cortex, immature CD4+8+ (double positive, DP) thymocytes express relatively few T cell receptors (TCRs) and contain diminished numbers of coreceptor-associated p56lck (lck) PTK molecules.
Autor:
Lawrence E. Samelson, Rémy Bosselut, Weiguo Zhang, Jeffrey L. Kopacz, Alfred Singer, Jennifer M. Ashe
Publikováno v:
The Journal of Experimental Medicine
Linker for activation of T cells (LAT) is an adaptor protein whose tyrosine phosphorylation is critical for transduction of the T cell receptor (TCR) signal. LAT phosphorylation is accomplished by the protein tyrosine kinase ZAP-70, but it is not at
Publikováno v:
Immunity. 4:495-504
The fate of developing CD4+CD8+ thymocytes is determined by signals transduced through surface TCR complexes. Here, we report that cross-linking of TCR on CD4+CD8+ thymocytes fails to activate ZAP70 protein tyrosine kinase and fails to initiate downs
Autor:
Dinah S. Singer, David L. Wiest, T. Kevin Howcroft, Ryo Abe, Izumi Negishi, Jennifer M. Ashe, Debbie M Kemper, Hon-Man Lee, Alfred Singer
Publikováno v:
Immunity. 6(6)
Development of immature CD4+CD8+ thymocytes into functionally mature CD4+ and CD8+ T cells is driven by selection events that require signals transduced through the T cell antigen receptor (TCR). Transduction of TCR signals in the thymus involves tyr