Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Jennifer M. , Finefield"'
Autor:
Sunderhaus, James D., McAfoos, Timothy J., Finefield, Jennifer M., Williams, Robert M., Hikaru, Kato, Aika, Kai, Tetsuro, Kawabata, ames D. , SunderhausJ, Timothy J. , McAfoos, Jennifer M. , Finefield, Yukihiko, Sugimoto, Robert M. , Williams, Sachiko, Tsukamoto
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27(22):4975-4978
The marine-derived Aspergillus protuberus MF297-2 and the terrestrial A. amoenus NRRL 35600 produce enantiomeric prenylated indole alkaloids. Investigation of biological activities of the natural and synthetic derivatives revealed that (−)-enantiom
Autor:
Robert M. Williams, Aika Kai, Jennifer M. Finefield, Tetsuro Kawabata, Sachiko Tsukamoto, Yukihiko Sugimoto, James D. Sunderhaus, Hikaru Kato, Timothy J. McAfoos
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(14)
The marine-derived Aspergillus protuberus MF297-2 and the terrestrial A. amoenus NRRL 35600 produce enantiomeric prenylated indole alkaloids. Investigation of biological activities of the natural and synthetic derivatives revealed that (−)-enantiom
Autor:
Jennifer M. Finefield, James D. Sunderhaus, David H. Sherman, Hikaru Kato, Robert M. Williams, Takashi Nakahara, Sachiko Tsukamoto, Ippei Kagiyama, Michitaka Yamaguchi
Publikováno v:
Tetrahedron Letters. 56(1):247-251
We previously described the bioconversion of Notoamide T into (+)-Stephacidin A and (−)-Notoamide B, which suggested that Versicolamide B (8) is biosynthesized from 6-epi-Notoamide T (10) via 6-epi-Stephacidin A. Here we report that [13C]2-10 was i
Autor:
Timothy J. McAfoos, Robert M. Williams, Jennifer M. Finefield, David H. Sherman, Hikaru Kato, Sachiko Tsukamoto, Shengying Li, James D. Sunderhaus
Publikováno v:
Organic Letters. 15:22-25
In an effort to further elucidate the biogenesis of the stephacidin and notoamide families of natural products, notoamide T has been identified as the likely precursor to stephacidin A. The total synthesis of notoamide T is described along with it is
Publikováno v:
Angewandte Chemie. 124:4886-4920
In der Natur werden chirale Substanzen meist in enantiomerenreiner Form synthetisiert – manchmal entstehen aber auch beide Enantiomere. Solche enantiomeren Naturstoffe konnen von einer Art oder von verschiedenen Gattungen und/oder Arten gebildet we
Autor:
Shengying Li, Jennifer M. Finefield, David H. Sherman, Robert M. Williams, James D. Sunderhaus, Timothy J. McAfoos
Publikováno v:
Journal of the American Chemical Society. 134:788-791
Notoamides produced by Aspergillus spp. bearing the bicyclo[2.2.2]diazaoctane core structure with unusual structural diversity represent a compelling system to understand the biosynthesis of fungal prenylated indole alkaloids. Herein, we report the i
Publikováno v:
The Journal of Organic Chemistry. 76:5954-5958
6-Hydroxydeoxybrevianamide E is proposed as a biosynthetic precursor to several advanced metabolites isolated from both marine-derived Aspergillus sp. and a terrestrial-derived Aspergillus versicolor. To verify the role of this reverse-prenylated ind
Autor:
Hikaru, Kato, Takashi, Nakahara, Michitaka, Yamaguchi, Ippei, Kagiyama, Jennifer M, Finefield, James D, Sunderhaus, David H, Sherman, Robert M, Williams, Sachiko, Tsukamoto
Publikováno v:
Tetrahedron letters. 56(1)
We previously described the bioconversion of Notoamide T into (+)-Stephacidin A and (−)-Notoamide B, which suggested that Versicolamide B (8) is biosynthesized from 6-epi-Notoamide T (10) via 6-epi-Stephacidin A. Here we report that [13C]2-10 was i
Autor:
Alexandro Dominguez, Shawn R. Hitchcock, Jonathan A. Groeper, Jennifer M. Finefield, Seshanand P. Chandrashekar, Raleigh W. Parrott, Trisha R. Hoover
Publikováno v:
Tetrahedron: Asymmetry. 17:1831-1841
Oxadiazinanones derived from (1 R ,2 S )-ephedrine and (1 R ,2 S )-norephedrine were employed in the asymmetric α-halo aldol reaction. The optimized yields and diastereoselectivities for the ephedrine based oxadiazinanone aldol reaction ranged from
Publikováno v:
Tetrahedron Letters. 47:2443-2446
The application of microwave heating to a silica-assisted solution-phase synthesis technique has been utilized to develop a rapid and efficient two-step protocol for the preparation of pyrazoles from aryl methyl ketone and aryl hydrazine monomers.