Tight Chk1 Levels Control Replication Cluster Activation in Xenopus.

Autor: Marie Platel, Arach Goldar, Jennifer M Wiggins, Pedro Barbosa, Pierre Libeau, Pierre Priam, Hemalatha Narassimprakash, Xenia Grodzenski, Kathrin Marheineke

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0129090 (2015)

DNA replication in higher eukaryotes initiates at thousands of origins according to a spatio-temporal program. The ATR/Chk1 dependent replication checkpoint inhibits the activation of later firing origins. In the Xenopus in vitro system initiations a

Externí odkaz: https://doaj.org/article/ff25cb007b4f4312bc9627fc872dbfad

Abstract 539: Development of a novel 5-plex copy number ddPCR assay for ctDNA analysis

Autor: Jennifer M. Wiggins, Mahrukh Syeda, David Polsky

Publikováno v: Cancer Research. 82:539-539

Background: Analysis of cell-free circulating tumor DNA (ctDNA) from blood provides an opportunity to detect potential mechanisms of resistance to targeted therapies in melanoma patients. Approximately 20% and 17% of patients undergoing BRAF targeted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35f8d8a9fc45e821d34db1b0372b077a
https://doi.org/10.1158/1538-7445.am2022-539

Exercise and the Tumor Microenvironment: Potential Therapeutic Implications

Autor: Bradley J. Behnke, Dietmar W. Siemann, Jennifer M. Wiggins, Dryden R. Baumfalk, Alexander B. Opoku-Acheampong

Publikováno v: Exercise and Sport Sciences Reviews. 46:56-64

An imbalance in oxygen delivery to demand in solid tumors results in local areas of hypoxia leading to poor prognosis for the patient. We hypothesize that aerobic exercise increases tumor blood flow, recruits previously nonperfused tumor blood vessel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14151fe471fe5c67b4cdf2c264e1b7c3
https://doi.org/10.1249/jes.0000000000000137

Validation of Circulating Tumor DNA Assays for Detection of Metastatic Melanoma

Autor: Mahrukh M, Syeda, Jennifer M, Wiggins, Broderick, Corless, Cindy, Spittle, George, Karlin-Neumann, David, Polsky

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2055

The detection of cell-free, circulating tumor DNA (ctDNA) in the blood of patients with solid tumors is often referred to as "liquid biopsy." ctDNA is particularly attractive as a candidate biomarker in the blood. It is relatively stable after blood

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2eba1275bb545381e2b8481a19a537a9
https://pubmed.ncbi.nlm.nih.gov/31502151

Reliability of blood lactate as a measure of exercise intensity in different strains of mice during forced treadmill running

Autor: Jennifer M. Wiggins, Pernille B. Elming, Lori Rice, Dietmar W. Siemann, Christine Pampo, Thomas Wittenborn, Jennifer A. Lee, Michael R. Horsman, Simon Lønbro

Publikováno v: PLoS ONE
PLoS ONE, Vol 14, Iss 5, p e0215584 (2019)
Lønbro, S, Wiggins, J M, Wittenborn, T, Elming, P B, Rice, L, Pampo, C, Lee, J A, Siemann, D W & Horsman, M R 2019, ' Reliability of blood lactate as a measure of exercise intensity in different strains of mice during forced treadmill running ', PLOS ONE, vol. 14, no. 5, e0215584 . https://doi.org/10.1371/journal.pone.0215584

Exercise has long been known to be beneficial to human health. Studies aimed at understanding the effects of exercise specifically focus on predetermined exercise intensities defined by measuring the aerobic capacity of each individual. Many disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f6e743b5674a20eabd80945e73a502a
http://europepmc.org/articles/PMC6499470