Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jennifer M Strazzeri"'
Autor:
Tyler Godat, Nicolas P Cottaris, Sara Patterson, Kendall Kohout, Keith Parkins, Qiang Yang, Jennifer M Strazzeri, Juliette E McGregor, David H Brainard, William H Merigan, David R Williams
Publikováno v:
PLoS ONE, Vol 17, Iss 11, p e0278261 (2022)
The primate fovea is specialized for high acuity chromatic vision, with the highest density of cone photoreceptors and a disproportionately large representation in visual cortex. The unique visual properties conferred by the fovea are conveyed to the
Externí odkaz:
https://doaj.org/article/147f6bed29484ff985eccf7d5a12e602
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194947 (2018)
Here we demonstrate the application of a method that could accelerate the development of novel therapies by allowing direct and repeatable visualization of cellular function in the living eye, to study loss of vision in animal models of retinal disea
Externí odkaz:
https://doaj.org/article/d4355daea34644b5a6afc17e9168ae62
Autor:
David M. Gamm, Lindsey D. Jager, Kamal Dhakal, Sara Stuedemann, Juliette E. McGregor, David A. DiLoreto, David R. Williams, Brittany Bateman, M. Joseph Phillips, Allison L. Ludwig, William H. Merigan, Ebrahim Aboualizadeh, Jennifer M. Strazzeri, Jennifer J. Hunter, Kelsy L. Nilles
Publikováno v:
Stem Cell Reports
Summary Stem cell-based transplantation therapies offer hope for currently untreatable retinal degenerations; however, preclinical progress has been largely confined to rodent models. Here, we describe an experimental platform for accelerating photor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c1db8ef5ce762316be98228de1087b
http://europepmc.org/articles/PMC7419740
http://europepmc.org/articles/PMC7419740
Autor:
Teresa Puthussery, Colin J Chu, David R. Williams, Peter J. Murphy, William H. Merigan, Tyler Godat, William S. Fischer, Zhengyang Xu, Brittany Bateman, Juliette E. McGregor, Karteek Kunala, Jennifer M. Strazzeri, Keith Parkins
Publikováno v:
McGregor, J E, Kunala, K, Xu, Z, Murphy, P J, Godat, T, Strazzeri, J M, Bateman, B A, Fischer, W S, Parkins, K, Chu, C J, Puthussery, T, Williams, D R & Merigan, W H 2021, ' Optogenetic therapy restores retinal activity in primate for at least a year following photoreceptor ablation ', Molecular Therapy . https://doi.org/10.1016/j.ymthe.2021.09.014
All retina-based vision restoration approaches rely on the assumption that photoreceptor loss does not preclude reactivation of the remaining retinal architecture. Whether extended periods of vision loss limit the efficacy of restorative therapies at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb4e16318cda80a4f91042948e378052
https://pubmed.ncbi.nlm.nih.gov/34547460
https://pubmed.ncbi.nlm.nih.gov/34547460
Autor:
Jennifer J. Hunter, Kamal Dhakal, David R. Williams, Sarah Walters, Brittany Bateman, Ebrahim Aboualizadeh, Jennifer M. Strazzeri, William H. Merigan, Christina Schwarz, Krystel R. Huxlin, Juliette E. McGregor
Publikováno v:
Translational Vision Science & Technology
Purpose The development of new approaches to human vision restoration could be greatly accelerated with the use of nonhuman primate models; however, there is a paucity of primate models of outer retina degeneration with good spatial localization. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a829c804ccd2a951c5e662341a6c4a06
http://europepmc.org/articles/PMC7414617
http://europepmc.org/articles/PMC7414617
Autor:
Kamal Dhakal, William H. Merigan, Tyler Godat, Juliette E. McGregor, Keith Parkins, Jennifer M. Strazzeri, Brittany Bateman, David R. Williams, William S. Fischer
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nature Communications
Optogenetic therapies for vision restoration aim to confer intrinsic light sensitivity to retinal ganglion cells when photoreceptors have degenerated and light sensitivity has been irreversibly lost. We combine adaptive optics ophthalmoscopy with cal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96deb6a30572f45b57b6cb42c13e0f38
https://doi.org/10.1038/s41467-020-15317-6
https://doi.org/10.1038/s41467-020-15317-6
Autor:
Jennifer M. Strazzeri, William S. Fischer, Christina Schwarz, Robin Sharma, Sarah Walters, Jennifer J. Hunter, Ethan A. Rossi, Dasha Nelidova, David A. DiLoreto, William H. Merigan, Botond Roska, David R. Williams
Progress is needed in developing animal models of photoreceptor degeneration and evaluating such models with longitudinal, noninvasive techniques. We employ confocal scanning laser ophthalmoscopy, optical coherence tomography (OCT) and high-resolutio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::549a321205677e6d336c792fa5438de0
https://europepmc.org/articles/PMC6363191/
https://europepmc.org/articles/PMC6363191/
Autor:
William H. Merigan, Wenjun Xiong, Soon Keen Cheong, David R. Williams, Jennifer M. Strazzeri, Constance L. Cepko
Publikováno v:
Retinal Degenerative Diseases ISBN: 9783319754017
Adv Exp Med Biol
Adv Exp Med Biol
Adaptive optics retinal imaging of fluorescent calcium indicators is a minimally invasive method used to study retinal physiology over extended periods of time. It is has potential for discovering novel retinal circuits, tracking retinal function in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::978ca24fc051c85614c5a766d399ba37
https://doi.org/10.1007/978-3-319-75402-4_17
https://doi.org/10.1007/978-3-319-75402-4_17
Autor:
Benjamin Masella, David A. DiLoreto, David R. Williams, Jennifer M. Strazzeri, Jennifer J. Hunter, Lu Yin, William H. Merigan, Richard T. Libby, William S. Fischer
Publikováno v:
Experimental Eye Research. 119:88-96
Insertion of light-gated channels into inner retina neurons restores neural light responses, light evoked potentials, visual optomotor responses and visually-guided maze behavior in mice blinded by retinal degeneration. This method of vision restorat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::844f57e02a2da2f78f590d68335085f1
https://doi.org/10.1016/j.exer.2013.11.001
https://doi.org/10.1016/j.exer.2013.11.001
Autor:
Laura Emptage, Joseph A. Araujo, Melanie C. W. Campbell, Ian R. A. Mackenzie, Michael T. Hamel, David DeVries, Jennifer J. Hunter, C. J. Cookson, William S. Fischer, Chongzhao Ran, Lewis DiVincenti, Melissa L Brooks, Marsha L. Kisilak, Jennifer M. Strazzeri, Theodore Chow
Publikováno v:
Alzheimer's & Dementia. 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b481bd9d48c230bbd9d387ad7420f93e
https://doi.org/10.1016/j.jalz.2016.06.577
https://doi.org/10.1016/j.jalz.2016.06.577