PAX-D: study protocol for a randomised placebo-controlled trial evaluating the efficacy and mechanism of pramipexole as add-on treatment for people with treatment resistant depression

Autor: Catherine J. Harmer, Ilina Singh, Ly-Mee Yu, Judit Simon, Paul Harrison, Glyn Lewis, Chloe Edwards, Sophie Roberts, Phil J. Cowen, Jennifer M Rendell, Sheena K. Au-Yeung, James Griffiths, Fiona Chan, Stuart Watson, Rafal Bogacz, Michael Browning, Anthony J. Cleare, Jonathan Evans, Milensu Shanyinde, John R. Geddes, David Kessler, Andrea Cipriani, M J Attenburrow

Publikováno v: Au-Yeung, S K, Griffiths, J, Roberts, S, Edwards, C, Yu, L-M, Bogacz, R, Rendell, J, Attenburrow, M-J, Watson, S, Chan, F, Cipriani, A, Cleare, A, Harmer, C J, Kessler, D, Evans, J, Lewis, G, Singh, I, Simon, J, Harrison, P J, Cowen, P, Shanyinde, M, Geddes, J & Browning, M 2021, ' PAX-D : study protocol for a randomised placebo-controlled trial evaluating the efficacy and mechanism of pramipexole as add-on treatment for people with treatment resistant depression ', Evidence-Based Mental Health . https://doi.org/10.1136/ebmental-2021-300282

IntroductionClinical depression is usually treated in primary care with psychological therapies and antidepressant medication. However, when patients do not respond to at least two or more antidepressants within a depressive episode, they are conside

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a58fa59b5fd180da47bfbaa524425ede
https://doi.org/10.1136/ebmental-2021-300282

Comparative economic evaluation of quetiapine plus lamotrigine combination vs quetiapine monotherapy (and folic acid vs placebo) in patients with bipolar depression (CEQUEL)

Autor: Susanne Mayer, Judit Simon, John R. Geddes, A Gardiner, Guy M. Goodwin, Jennifer M Rendell

Publikováno v: Bipolar Disorders

Objectives Although not licensed for acute bipolar depression, lamotrigine has evidence for efficacy in trials and its use is recommended in guidelines. So far there had been no prospective health economic evaluation of its use. Methods Cost‐utilit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba1ed8b681965a9811b7587365260eae
https://pubmed.ncbi.nlm.nih.gov/30698326

Psychoeducation and online mood tracking for patients with bipolar disorder: A randomised controlled trial

Autor: Jennifer M Rendell, H McMahon, Chris Hinds, David J. Miklowitz, Guy M. Goodwin, Merryn Voysey, Amy C. Bilderbeck, Judit Simon, Lauren Z Atkinson, John R. Geddes, Emily A. Holmes, Jonathan Price

Background: Psychoeducation is an effective adjunct to medications in bipolar disorder (BD). Brief psychoeducational approaches have been shown to improve early identification of relapse. However, the optimal method of delivery of psychoeducation rem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2225b4218d306f07bf09f875bebcd60a
https://doi.org/10.1016/j.jad.2016.06.064

Clinical and regulatory implications of active run-in phases in long-term studies for bipolar disorder

Autor: John R. Geddes, Corrado Barbui, Andrea Cipriani, Jennifer M Rendell

Objective: The integration of new treatments into the market and routine clinical practice should be dependent on robustness of evidence from randomised controlled trials (RCTs). We assessed study designs of long-term studies for bipolar disorder of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::678f7c2bf20a027839608b74d87afb4f
https://doi.org/10.1111/acps.12223

The longitudinal course of bipolar disorder as revealed through weekly text messaging: a feasibility study

Autor: John R. Geddes, Jennifer M Rendell, William M. Stevens, David J. Miklowitz, Guy M. Goodwin, Jedediah M Bopp

Publikováno v: Bipolar Disorders. 12:327-334

Our limited understanding of the course of mood symptoms in bipolar disorder impedes the development of effective treatments. A greater understanding of weekly fluctuations in the course of mood symptoms in bipolar disorder could improve relapse prev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7022da0d5a397eb97ab078127c79eddb
https://doi.org/10.1111/j.1399-5618.2010.00807.x