Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jennifer M Margison"'
Publikováno v:
University of Manchester-PURE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75712ba6c04ed639959a1a330c238d3f
https://doi.org/10.1016/s0305-7372(96)90009-2
https://doi.org/10.1016/s0305-7372(96)90009-2
Publikováno v:
British Journal of Clinical Pharmacology. 30:140-143
The effect of age on the pharmacokinetics of ifosfamide was studied in 20 patients with advanced non small cell lung cancer. A positive correlation was found between the elimination half-life of ifosfamide and age (r = 0.48, 0.05 less than P less tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e5b02d2b607f5b302842a6867a2b6e4
https://doi.org/10.1111/j.1365-2125.1990.tb03754.x
https://doi.org/10.1111/j.1365-2125.1990.tb03754.x
Autor:
Peter M Wilkinson, Jennifer M Margison, Michael J. Lind, S. B. Lucas, Miguel H. Bronchud, Anthony Howell
Publikováno v:
Cancer Chemotherapy and Pharmacology. 25:435-439
Recombinant human granulocyte colony-stimulating factor (G-CSF) has been shown to reduce neutropenia following cytotoxic therapy, thereby enabling dose escalation to improve the response rate. It is important to know whether drug kinetics change as d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7caf885cf9e51636033148f73ba8621
https://doi.org/10.1007/bf00686055
https://doi.org/10.1007/bf00686055
Autor:
Anthony Howell, Mark Clemons, Audrey Griffiths, Hassan El Teraifi, Malcolm R Ranson, Geoffrey P. Margison, Charles Q Morris, Jane Kelly, Jennifer M Margison
Publikováno v:
International journal of cancer. 103(5)
We assessed whether split dosing with the methylating agent DTIC is an effective strategy for inactivating the DNA repair protein O6-alkylguanine DNA-ATase in order to decrease tumour resistance to BCNU. ATase levels in PBMCs were used as a surrogate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070945ad4d90d3560caf48bbf6d1b7cc
https://pubmed.ncbi.nlm.nih.gov/12494480
https://pubmed.ncbi.nlm.nih.gov/12494480
Publikováno v:
Critical reviews in oncology/hematology. 37(2)
Anthracyclines are amongst the most active drugs in the treatment of breast cancer. Stealth liposomal doxorubicin (Caelyx, Doxil, Alza Pharmaceuticals Inc.) is a promising new agent under investigation for the treatment of breast cancer and other sol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::803905b83e0280f83379a81f63c0e4fc
https://pubmed.ncbi.nlm.nih.gov/11166584
https://pubmed.ncbi.nlm.nih.gov/11166584
Autor:
Nick Thatcher, John Radford, Ric Swindell, Jennifer M Margison, Peter M Wilkinson, Michael J. Lind
Publikováno v:
Journal of cancer research and clinical oncology. 117
Dose fractionation is known to reduce the toxicity of ifosfamide and also results in an increased production of alkylating metabolites. Administration by slow infusion using the convenience of ambulatory pumps is therefore of interest. We used HPLC t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e6efe3366c26f3ea4f443966fc3f9d5
https://pubmed.ncbi.nlm.nih.gov/1795005
https://pubmed.ncbi.nlm.nih.gov/1795005
Publikováno v:
Cancer Chemotherapy and Pharmacology. 25:139-142
The pharmacokinetics of intravenous ifosfamide were determined in 16 patients with carcinoma of the bronchus. In all 25% (4) of these patients were obese (i.e. greater than 20% over their ideal body weight). The terminal elimination half-life (t1/2 b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f1bf5fc971f67a3e6c305f655a2a12
https://doi.org/10.1007/bf00692355
https://doi.org/10.1007/bf00692355
Publikováno v:
Cancer Letters. 2:79-85
Rats were exposed chronically to unlabelled N,N-dimethylnitrosamine (25 ppm in the drinking water) then given a single dose of N-[3H]methyl-N-nitrosourea (10 mg/kg body weight). The rates of loss of tritium-labeled 7-methylguanine, O6-methylguanine a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fefae1e38435479e693ba4ad6a107810
https://doi.org/10.1016/s0304-3835(76)80015-8
https://doi.org/10.1016/s0304-3835(76)80015-8
Publikováno v:
Biomedical Chromatography. 1:101-103
A high performance liquid chromatography method is described for measuring Ifosfamide (I) in human serum. This involves solvent extraction, reverse phase HPLC and UV detection at 190 nm. Standard curves of peak height x detector sensitivity versus I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::194b677648b3cb0b3726fe3e4fd56221
https://doi.org/10.1002/bmc.1130010303
https://doi.org/10.1002/bmc.1130010303
Publikováno v:
University of Manchester-PURE
The clinical pharmacology of 4-demethoxydaunorubicin (4-DMDNR) was studied in 28 patients with advanced breast cancer, using a sensitive reverse-phase HPLC technique. All patients had normal renal and hepatic function. The serum levels of 4-DMDNR aft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c49fd38daaf4ae79b0d7ae9018316cd4
https://doi.org/10.1007/bf00254566
https://doi.org/10.1007/bf00254566