Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Jennifer M Hurley"'
Autor:
Meaghan S. Jankowski, Daniel Griffith, Divya G. Shastry, Jacqueline F. Pelham, Garrett M. Ginell, Joshua Thomas, Pankaj Karande, Alex S. Holehouse, Jennifer M. Hurley
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Organismal physiology is widely regulated by the molecular circadian clock, a feedback loop composed of protein complexes whose members are enriched in intrinsically disordered regions. These regions can mediate protein-protein interactions
Externí odkaz:
https://doaj.org/article/49bef495a3fd4cba89ab0c05a9bd35aa
Autor:
Mariana P. Cervantes-Silva, Richard G. Carroll, Mieszko M. Wilk, Diana Moreira, Cloe A. Payet, James R. O’Siorain, Shannon L. Cox, Lauren E. Fagan, Paula A. Klavina, Yan He, Tabea Drewinski, Alan McGinley, Sharleen M. Buel, George A. Timmons, James O. Early, Roger J. S. Preston, Jennifer M. Hurley, David K. Finlay, Ingmar Schoen, F. Javier Sánchez-García, Kingston H. G. Mills, Annie M. Curtis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Circadian rhythms are known to impact a range of biological processes including in the immune system. Here the authors show how circadian rhythms modulate the T cell response to vaccination via regulation of dendritic cell metabolism.
Externí odkaz:
https://doaj.org/article/4caf147bafa74b10bfcfd8fe7b6234a5
Autor:
Jacqueline F. Pelham, Alexander E. Mosier, Samuel C. Altshuler, Morgan L. Rhodes, Christopher L. Kirchhoff, William B. Fall, Catherine Mann, Lisa S. Baik, Joanna C. Chiu, Jennifer M. Hurley
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112376- (2023)
Summary: Biology is tuned to the Earth’s diurnal cycle by the circadian clock, a transcriptional/translational negative feedback loop that regulates physiology via transcriptional activation and other post-transcriptional mechanisms. We hypothesize
Externí odkaz:
https://doaj.org/article/c80d004282bf4daf8ba96764cdb5aff1
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionSustained neuroinflammation is a major contributor to the progression of neurodegenerative diseases such as Alzheimer’s (AD) and Parkinson’s (PD) diseases. Neuroinflammation, like other cellular processes, is affected by the circadian
Externí odkaz:
https://doaj.org/article/28e0e1d5665f4796b26a416da821bf52
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-13 (2020)
Abstract Introduction The circadian circuit, a roughly 24 h molecular feedback loop, or clock, is conserved from bacteria to animals and allows for enhanced organismal survival by facilitating the anticipation of the day/night cycle. With circadian r
Externí odkaz:
https://doaj.org/article/c093cde4823d40de9a7dab418080d432
Autor:
Gretchen T Clark, Yanlei Yu, Cooper A Urban, Guo Fu, Chunyu Wang, Fuming Zhang, Robert J Linhardt, Jennifer M Hurley
Publikováno v:
PLoS Genetics, Vol 18, Iss 2, p e1009994 (2022)
Alzheimer's Disease (AD) is a neuroinflammatory disease characterized partly by the inability to clear, and subsequent build-up, of amyloid-beta (Aβ). AD has a bi-directional relationship with circadian disruption (CD) with sleep disturbances starti
Externí odkaz:
https://doaj.org/article/f1812de39f4e451d97c846f31d199435
Autor:
Rigzin Dekhang, Cheng Wu, Kristina M. Smith, Teresa M. Lamb, Matthew Peterson, Erin L. Bredeweg, Oneida Ibarra, Jillian M. Emerson, Nirmala Karunarathna, Anna Lyubetskaya, Elham Azizi, Jennifer M. Hurley, Jay C. Dunlap, James E. Galagan, Michael Freitag, Matthew S. Sachs, Deborah Bell-Pedersen
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 1, Pp 129-142 (2017)
Light and the circadian clock have a profound effect on the biology of organisms through the regulation of large sets of genes. Toward understanding how light and the circadian clock regulate gene expression, we used genome-wide approaches to identif
Externí odkaz:
https://doaj.org/article/112e700683de4c5c93ba8c1f7185c404
IntroductionSustained neuroinflammation is a major contributor to the progression of neurodegenerative diseases such as Alzheimer’s (AD) and Parkinson’s (PD) diseases. Neuroinflammation, like other cellular processes, is affected by the circadian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de1d0432ae0cd82d3f7bf921bc5ea11
https://doi.org/10.1101/2022.11.07.515487
https://doi.org/10.1101/2022.11.07.515487
Autor:
Jennifer M. Hurley
Publikováno v:
Biophysical Journal. 122:452a-453a
Autor:
Sharleen M Buel, Shayom Debopadhaya, Hannah De los Santos, Kaelyn M Edwards, Alexandra M David, Uyen H Dao, Kristin P Bennett, Jennifer M Hurley
Publikováno v:
G3 (Bethesda, Md.). 12(9)
Circadian rhythms broadly regulate physiological functions by tuning oscillations in the levels of mRNAs and proteins to the 24-h day/night cycle. Globally assessing which mRNAs and proteins are timed by the clock necessitates accurate recognition of