Výsledky vyhledávání - "Jennifer M Dan"

Akademický článek

Definition of Human Epitopes Recognized in Tetanus Toxoid and Development of an Assay Strategy to Detect Ex Vivo Tetanus CD4+ T Cell Responses.

Autor: Ricardo da Silva Antunes, Sinu Paul, John Sidney, Daniela Weiskopf, Jennifer M Dan, Elizabeth Phillips, Simon Mallal, Shane Crotty, Alessandro Sette, Cecilia S Lindestam Arlehamn

Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0169086 (2017)

Despite widespread uses of tetanus toxoid (TT) as a vaccine, model antigen and protein carrier, TT epitopes have been poorly characterized. Herein we defined the human CD4+ T cell epitope repertoire by reevaluation of previously described epitopes an

Externí odkaz: https://doaj.org/article/adde539304ad498291b441b533bd63d8

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Akademický článek

Comparative analysis of activation induced marker (AIM) assays for sensitive identification of antigen-specific CD4 T cells.

Autor: Samantha Reiss, Amy E Baxter, Kimberly M Cirelli, Jennifer M Dan, Antigoni Morou, Audrey Daigneault, Nathalie Brassard, Guido Silvestri, Jean-Pierre Routy, Colin Havenar-Daughton, Shane Crotty, Daniel E Kaufmann

Publikováno v: PLoS ONE, Vol 12, Iss 10, p e0186998 (2017)

The identification and study of antigen-specific CD4 T cells, both in peripheral blood and in tissues, is key for a broad range of immunological research, including vaccine responses and infectious diseases. Detection of these cells is hampered by bo

Externí odkaz: https://doaj.org/article/c8fcca0f39e748e4b4f7d2b553b8dd01

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Akademický článek

Cooperative stimulation of dendritic cells by Cryptococcus neoformans mannoproteins and CpG oligodeoxynucleotides.

Autor: Jennifer M Dan, Jennifer P Wang, Chrono K Lee, Stuart M Levitz

Publikováno v: PLoS ONE, Vol 3, Iss 4, p e2046 (2008)

While mannosylation targets antigens to mannose receptors on dendritic cells (DC), the resultant immune response is suboptimal. We hypothesized that the addition of toll-like receptor (TLR) ligands would enhance the DC response to mannosylated antige

Externí odkaz: https://doaj.org/article/1556911a1a1f44b3821e52c178f39b73

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Akademický článek

COVID-19 lung disease shares driver AT2 cytopathic features with Idiopathic pulmonary fibrosis

Autor: Saptarshi Sinha, Vanessa Castillo, Celia R. Espinoza, Courtney Tindle, Ayden G. Fonseca, Jennifer M. Dan, Gajanan D. Katkar, Soumita Das, Debashis Sahoo, Pradipta Ghosh

Publikováno v: EBioMedicine, Vol 82, Iss , Pp 104185- (2022)

Summary: Background: In the aftermath of Covid-19, some patients develop a fibrotic lung disease, i.e., post-COVID-19 lung disease (PCLD), for which we currently lack insights into pathogenesis, disease models, or treatment options. Methods: Using an

Externí odkaz: https://doaj.org/article/d5f99c58879a40249ae39280c7a5fbc3

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Akademický článek

AI-guided discovery of the invariant host response to viral pandemics

Publikováno v: EBioMedicine, Vol 68, Iss , Pp 103390- (2021)

Background: Coronavirus Disease 2019 (Covid-19) continues to challenge the limits of our knowledge and our healthcare system. Here we sought to define the host immune response, a.k.a, the “cytokine storm” that has been implicated in fatal COVID-1

Externí odkaz: https://doaj.org/article/9fb0f37039614a41b6bb64dc3f67cb9a

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Akademický článek

HIV but Not CMV Replication Alters the Blood Cytokine Network during Early HIV Infection in Men

Autor: Christophe Vanpouille, Alan Wells, Jennifer M. Dan, Stephen A. Rawlings, Susan Little, Wendy Fitzgerald, Leonid Margolis, Sara Gianella

Publikováno v: Viruses, Vol 14, Iss 8, p 1833 (2022)

Objective: CMV coinfection contributes to sustained immune activation in people with chronic HIV. In particular, asymptomatic CMV shedding in semen has been associated with increased local and systemic immune activation, even during suppressive antir

Externí odkaz: https://doaj.org/article/bc440644bc5a43908790c98551304a26

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