Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Jennifer M, Kavran"'
Publikováno v:
Biochemistry
Canonically, MST1/2 functions as a core kinase of the Hippo pathway and noncanonically during both apoptotic signaling and with RASSFs in T-cells. Faithful signal transduction by MST1/2 relies on both appropriate activation and regulated substrate ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce55ebaa107f160c583850dc7e5e0096
https://doi.org/10.1021/acs.biochem.2c00022
https://doi.org/10.1021/acs.biochem.2c00022
Publikováno v:
bioRxiv
The Hippo pathway controls tissue growth and regulates stem cell fate through the activities of core kinase cassette that begins with the Sterile 20-like kinase MST1/2. Activation of MST1/2 relies ontrans-autophosphorylation but the details of the me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92426993c51dafe322b4d3677e9cca9d
https://doi.org/10.1101/2023.03.09.531926
https://doi.org/10.1101/2023.03.09.531926
Autor:
Teresa T Bonello, Danfeng Cai, Georgina C Fletcher, Kyler Wiengartner, Victoria Pengilly, Kimberly S Lange, Zhe Liu, Jennifer Lippincott‐Schwartz, Jennifer M Kavran, Barry J Thompson
The Hippo pathway was originally discovered to control tissue growth in Drosophila and includes the Hippo kinase (Hpo; MST1/2 in mammals), scaffold protein Salvador (Sav; SAV1 in mammals) and the Warts kinase (Wts; LATS1/2 in mammals). The Hpo kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed60927d663b1406c463ef1b77686d22
Canonically, MST1/2 functions as a core kinase of the Hippo pathway and non-canonically is both activated during apoptotic signaling and acts in concert with RASSFs in T-cells. Faithful signal transduction relies on both appropriate activation and re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7486843cccc1a6d8e10eabf2259c90fc
https://doi.org/10.1101/2022.01.13.476221
https://doi.org/10.1101/2022.01.13.476221
Publikováno v:
The Journal of Biological Chemistry
The nitroreductase superfamily of enzymes encompasses many flavin mononucleotide (FMN)-dependent catalysts promoting a wide range of reactions. All share a common core consisting of an FMN-binding domain, and individual subgroups additionally contain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be79555d175b00f23fd0c65fac08e16c
https://pubmed.ncbi.nlm.nih.gov/34748729
https://pubmed.ncbi.nlm.nih.gov/34748729
Autor:
Jennifer M Kavran, Jacqueline M McCabe, Patrick O Byrne, Mary Katherine Connacher, Zhihong Wang, Alexander Ramek, Sarvenaz Sarabipour, Yibing Shan, David E Shaw, Kalina Hristova, Philip A Cole, Daniel J Leahy
Publikováno v:
eLife, Vol 3 (2014)
The type I insulin-like growth factor receptor (IGF1R) is involved in growth and survival of normal and neoplastic cells. A ligand-dependent conformational change is thought to regulate IGF1R activity, but the nature of this change is unclear. We poi
Externí odkaz:
https://doaj.org/article/3afe172341a44b0e9531fe01009e541c
Publikováno v:
J Biol Chem
The Hippo pathway plays an important role in developmental biology, mediating organ size by controlling cell proliferation through the activity of a core kinase cassette. Multiple upstream events activate the pathway, but how each controls this core
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b8d692cf3d88b9bde0a15b93c43748c
https://pubmed.ncbi.nlm.nih.gov/32994222
https://pubmed.ncbi.nlm.nih.gov/32994222
Autor:
Angela Patterson, Katherine W. Tripp, Jennifer M. Kavran, Brian Bothner, Daniel R. DeAngelis, T.J. Koehler, Kyler A. Weingartner, Leah Cairns
Hippo pathway signaling limits cell growth and proliferation and maintains the stem-cell niche. These cellular events result from the coordinated activity of a core kinase cassette that is regulated, in part, by interactions involving Hippo, Salvador
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bd12c6c7377ed97df8154990b07c33f
https://zenodo.org/record/3922165
https://zenodo.org/record/3922165
Autor:
T. Thao Tran, Brendan H. Fowl, Jennifer M. Kavran, Leah Cairns, Angela Patterson, Yoo Jin Kim, Brian Bothner
Publikováno v:
Journal of Biological Chemistry. 293:5532-5543
The Hippo pathway controls cell proliferation and differentiation through the precisely tuned activity of a core kinase cassette. The activity of Hippo kinase is modulated by interactions between its C-terminal coiled-coil, termed the SARAH domain, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1310bcf634c85a8fbeee3ed0e184f8b
https://doi.org/10.1074/jbc.ra117.000923
https://doi.org/10.1074/jbc.ra117.000923
Publikováno v:
ACS Chemical Biology. 12:601-610
During development, the Hippo pathway regulates the balance between cell proliferation and apoptosis to control organ size. Appropriate Hippo signaling is associated with stem cell maintenance, while inappropriate signaling can result in tumorigenesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26d77bf7c10c787c960f2bb8a87e0b9a
https://doi.org/10.1021/acschembio.6b01058
https://doi.org/10.1021/acschembio.6b01058