Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Jennifer Lynn Gage"'
Autor:
László Ürögdi, Alex Rohde, Jennifer Lynn Gage, Sasha Gragerov, György Dormán, Rene Onrust, Vince Florio, Neil S. Cutshall, Derek Johnston, Andrew Osnowski, Harbol Kevin L, Thomas Neil Wheeler, Lee Mitchell, Wendy MacDonald
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:4155-4159
Cyclic nucleotide phosphodiesterases (PDEs) are represented by a large superfamily of enzymes. A series of hydrazone-based inhibitors was synthesized and shown to be novel, potent, and selective against PDE10A. Optimized compounds of this class were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e228427176a466f0fe79d22fac4b0b4
https://doi.org/10.1016/j.bmcl.2011.05.100
https://doi.org/10.1016/j.bmcl.2011.05.100
Autor:
Lauren Hamilton, Rene Onrust, Thomas Neil Wheeler, Charles Prince Zuta, Sasha Gragerov, Alex Rohde, Shawn McKee, Neil S. Cutshall, Jennifer Lynn Gage, Vince Florio, Harbol Kevin L, Galina Gragerova, Hui-Rong Shen
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(17)
A series of 2-methoxyacylhydrazones were optimized to yield compounds with high affinity for PDE10A. Several compounds demonstrated efficacy in animal models of schizophrenia, including conditioned avoidance response and a pro-psychotic phencyclidine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d86d367c4f6331c08078f09eadeaaf6b
https://pubmed.ncbi.nlm.nih.gov/22841436
https://pubmed.ncbi.nlm.nih.gov/22841436