Stem Cell Therapies for Treatment of Liver Disease

Autor: Clara Nicolas, Yujia Wang, Jennifer Luebke-Wheeler, Scott L. Nyberg

Publikováno v: Biomedicines, Vol 4, Iss 1, p 2 (2016)

Cell therapy is an emerging form of treatment for several liver diseases, but is limited by the availability of donor livers. Stem cells hold promise as an alternative to the use of primary hepatocytes. We performed an exhaustive review of the litera

Externí odkaz: https://doaj.org/article/ac3e8fcb09fe4b0a840bc17049a3d0e9

Rat hepatocyte spheroids formed by rocked technique maintain differentiated hepatocyte gene expression and function

Autor: Harris Khan, Piero Rinaldo, Scott L. Nyberg, Bruce Amiot, Rory P. Remmel, Colleen M. Brophy, Jennifer Luebke-Wheeler

Publikováno v: Hepatology. 49:578-586

The culture of primary hepatocytes as spheroids creates an efficient 3-dimensional tissue construct for hepatic studies in vitro. Spheroids possess structural polarity and functional bile canaliculi with normal differentiated function. Thus, hepatocy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a6628e97404e9519f57364458bec81
https://doi.org/10.1002/hep.22674

Stem Cell Therapies for Treatment of Liver Disease

Autor: Scott L. Nyberg, Yujia Wang, Jennifer Luebke-Wheeler, Clara T. Nicolas

Publikováno v: Biomedicines
Biomedicines, Vol 4, Iss 1, p 2 (2016)

Cell therapy is an emerging form of treatment for several liver diseases, but is limited by the availability of donor livers. Stem cells hold promise as an alternative to the use of primary hepatocytes. We performed an exhaustive review of the litera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f11f9535fd9b2a10dd0381659357dbfd
https://pubmed.ncbi.nlm.nih.gov/28536370

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

Autor: Kathrin Schmich, Christoph Meyer, Steven Dooley, Gerd A. Kullak-Ublick, Daniel J. Maltman, Ernst H. K. Stelzer, Jessica Mwinyi, Valentina Fonsato, Albert Braeuning, Melvin E. Andersen, María José Gómez-Lechón, Georg Damm, Philip Hewitt, J. Craig Rowlands, Jingbo Pi, Lena Gustavsson, Chong Su Cho, Stefan Przyborski, Thomas S. Weiss, Joanna Fraczek, Ute Albrecht, Regina Stöber, Britta Burkhardt, Adam S. Hayward, Sudin Bhattacharya, Bruno Stieger, Tamara Vanhaecke, Cliff Rowe, Kathy Yarborough, Celine Schelcher, Neil R. Cameron, Andreas K. Nussler, Seddik Hammad, Rowena Eakins, Olaf Dirsch, Dean J. Naisbitt, Dieter Häussinger, Robert A. Budinsky, Karine Sá Ferreira, Christopher E. Goldring, Jennifer Luebke-Wheeler, Giovanni Camussi, J. Brian Houston, Jennifer Bolleyn, Andrew Gibson, Patrick D. McMullen, Hermann-Georg Holzhütter, Michael Schwarz, Peng Lu, Jens M. Kelm, Francesco Pampaloni, Christelle Guyot, Jens Hrach, Uta Dahmen, J Böttger, Nicola J. Hewitt, Bijay Singh, Verena Keitel, Christoph Borner, Yuichi Sugiyama, Anna Lutz, Edward L. LeCluyse, Patricio Godoy, Simon Messner, Dirk Drasdo, Nariman Ansari, Courtney G. Woods, Irmgard Merfort, Rolf Gebhardt, María Teresa Donato, Yun Jaie Choi, Claus Kordes, B. Kevin Park, Jan G. Hengstler, Jinghai James Xu, Stefan Hoehme, Claus Hellerbrand, Peter Olinga, Hartmut Jaeschke, Linda J. Pluta, Agata Widera, Johannes G. Bode, Anup Ramachandran, Kiyomi Ito, Matthias Glanemann, David Hallifax, Geny M. M. Groothuis, Wolfgang E. Thasler, Mathieu Vinken, Ciro Tetta, Vera Rogiers, Madlen Matz-Soja, Jian Dong

Publikováno v: ARCHIVES OF TOXICOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Archives of toxicology, 2013, Vol.87(8), pp.1315-1530 [Peer Reviewed Journal]
Archives of Toxicology
Archives of Toxicology, Springer Verlag, 2013, 87 (8), pp.1315-530. ⟨10.1007/s00204-013-1078-5⟩
Vrije Universiteit Brussel
Archives of Toxicology Vol. 87 Issue 8: pp. 1315-1530
Archives of Toxicology, 2013, 87 (8), pp.1315-530. ⟨10.1007/s00204-013-1078-5⟩
Archives of Toxicology; Vol 87
RODERIC. Repositorio Institucional de la Universitat de Valéncia
Archives of Toxicology; 87(8), pp 1315-1530 (2013)

This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, zonated lobules, the liver consists of approximately 80 % hepatocyte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dfbe0eba17d5b39307562eee7f07503
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=2598

Portal hypertension correlates with splenic stiffness as measured with MR elastography

Autor: Scott L. Nyberg, Jennifer Luebke-Wheeler, Jayant A. Talwalkar, Richard L. Ehman, Joseph B. Lillegard, Travis J. McKenzie, Meng Yin, Geir I. Nedredal

Publikováno v: Journal of magnetic resonance imaging : JMRI. 34(1)

To investigate the correlation between MR elastography (MRE) assessed spleen stiffness and direct portal vein pressure gradient (D-HVPG) measurements in a large animal model of portal hypertension.Cholestatic liver disease was established in adult ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::233a87c61ba3e22565df4a06e850ac72
https://pubmed.ncbi.nlm.nih.gov/21608066