Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jennifer Lea Rutherford"'
Publikováno v:
Journal of Fluorine Chemistry. 135:354-357
A facile and fluorination-free synthesis of 3,3-difluoropyrrolidine hydrochloride (3), an important synthon in the synthesis of biologically active compounds, is reported. The seven-step synthesis starts from the commercially available 2-chloro-2,2-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::526c08cd9417ee45b10140fbbb4626c3
https://doi.org/10.1016/j.jfluchem.2011.08.009
https://doi.org/10.1016/j.jfluchem.2011.08.009
Autor:
Paul Ahlijanian, Jeroen Konings, Roberto Colon-Cruz, Dominique Monique Char Callant, Ben de Lange, Robert de Pater, Joel M. Hawkins, Lulin Wei, Jean Andrien, Jennifer Lea Rutherford, Kurt Stickley, Jos Hulshof, Peter Johannes Dominicus Maas, Timothy Norris, Roel Vollinga, Mark T. Barrila, David W. L. Sung, Michel Couturier, and Natalka Johnson, Ioulia V. Loubkina, Elena Daia, Brian M. Andresen, David H. Brown Ripin, Jos Versleijen
Publikováno v:
Organic Process Research & Development. 9:432-439
The optimization of the synthesis of 6β-hydroxymethylsulbactam is described. The primary challenge in this synthesis is the installation of the 6β-hydroxymethyl group with the proper stereochemistry. Engineering challenges associated with the addit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29ceefb76dc780bb9512786982ff4877
https://doi.org/10.1021/op050047a
https://doi.org/10.1021/op050047a
Autor:
Joel M. Hawkins, Lulin Wei, Dennis E. Bourassa, Peter Robert Rose, Jeffery W. Raggon, A. Morgan Stewart, Heather N. Frost, James E. Phillips, Jennifer Lea Rutherford, Michael J. Castaldi, Barbara J. Sitter, Stephen S. Massett, Phillip J. Johnson, Michael G. Vetelino, Thomas Andrew Brandt, David H. Brown Ripin, Karin Neumann
Publikováno v:
Organic Process Research & Development. 9:440-450
The synthesis of the anti-cancer compound 2-methoxy-N-(3-{4-[3-methyl-4-(6-methyl-pyridin-3-yloxy)phenylamino]quinazolin-6-yl}-E-allyl)acetamide (CP-724,714) (1) on multikilogram scale using several different synthetic routes is described. Applicatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5fded034f53a5be141f6f46ced0a248
https://doi.org/10.1021/op050039u
https://doi.org/10.1021/op050039u
Autor:
Teresa W. Makowski, Ruth E. McDermott, Paige Roanne Palmer Brooks, Michael C. Wirtz, Crystal G. Bashore, Michael G. Vetelino, John A. Ragan, David C. Whritenour, Jotham Wadsworth Coe, Heather N. Frost, Steven J. Brenek, Jennifer Lea Rutherford
Publikováno v:
Organic letters. 8(26)
[Structure: see text] The development of a concise enantioselective synthesis of nicotinic alkaloid 1 is presented. The route features the synthesis and use of a "stable" aliphatic triflate 21 in an alkylation step to generate Heck precursor 24 and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d80965a90b4448a18d3169e58916042b
https://pubmed.ncbi.nlm.nih.gov/17165901
https://pubmed.ncbi.nlm.nih.gov/17165901
