Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Jennifer Landsberg"'
Autor:
Tanja Fetter, Simon Fietz, Maya Bertlich, Christine Braegelmann, Luka de Vos-Hillebrand, Joerg Wenzel, Annkristin Heine, Jennifer Landsberg, Philipp Jansen
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionOver the past decade, immune checkpoint inhibitors such as antibodies against cytotoxicity T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1) have become an important armamentarium against a broad spectr
Externí odkaz:
https://doaj.org/article/5b1358c322a14c438a32a1c798e8b362
Autor:
Simon Fietz, Anne Fröhlich, Cornelia Mauch, Luka de Vos-Hillebrand, Tanja Fetter, Jennifer Landsberg, Friederike Hoffmann, Judith Sirokay
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThe anti-programmed cell death protein 1 (PD-1) antibody cemiplimab has shown promising results in the treatment of unresectable or metastatic squamous cell carcinoma, however, frequently leads to immune-related adverse events limiting th
Externí odkaz:
https://doaj.org/article/5c65c93846d04e19a86da137502b47bd
Autor:
Niklas Klümper, Lennert Wüst, Jonas Saal, Damian J. Ralser, Romina Zarbl, Jonas Jarczyk, Johannes Breyer, Danijel Sikic, Bernd Wullich, Christian Bolenz, Florian Roghmann, Michael Hölzel, Manuel Ritter, Sebastian Strieth, Arndt Hartmann, Philipp Erben, Ralph M. Wirtz, Jennifer Landsberg, Dimo Dietrich, Markus Eckstein
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTPD-L1 status assessed by immunohistochemistry (IHC) has failed to reliably predict outcomes for patients with metastatic urothelial carcinoma (mUC) on immune checkpoint blockade (ICB). PD-L1 promoter methylation is an epigenetic mechanism tha
Externí odkaz:
https://doaj.org/article/db84a83835784401bcaeca4a8df3487d
Autor:
Friederike Hoffmann, Alina Franzen, Luka de Vos, Lennert Wuest, Zsófi Kulcsár, Simon Fietz, Alexander Philippe Maas, Sarah Hollick, Marie Yatou Diop, Jennis Gabrielpillai, Timo Vogt, Pia Kuster, Romina Zarbl, Joern Dietrich, Glen Kristiansen, Peter Brossart, Jennifer Landsberg, Sebastian Strieth, Dimo Dietrich
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-13 (2023)
Abstract Background The majority of patients with recurrent or metastasized head and neck squamous cell carcinoma (HNSCC) do not benefit from immune checkpoint blockade (ICB) while several patients experience severe and persistent immune-mediated sid
Externí odkaz:
https://doaj.org/article/2828807dfb384e6996689ecfb93a477e
Autor:
Damian J. Ralser, Emmanuelle Herr, Luka de Vos, Zsófi Kulcsár, Romina Zarbl, Niklas Klümper, Gerrit H. Gielen, Alexander Philippe Maas, Friederike Hoffmann, Jörn Dietrich, Pia Kuster, Alexander Mustea, Nicole Glodde, Glen Kristiansen, Sebastian Strieth, Jennifer Landsberg, Dimo Dietrich
Publikováno v:
Biomarker Research, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract Background Inducible T cell costimulator ICOS is an emerging target in immuno-oncology. The aim of this study was to investigate the epigenetic regulation of ICOS in melanoma by DNA methylation. Methods We comprehensively investigate ICOS DN
Externí odkaz:
https://doaj.org/article/e3bb36e51ff44e6f9b8d700fc99a8755
Autor:
Caterina Giraulo, Roberta Turiello, Lavinia Orlando, Sonia Leonardelli, Jennifer Landsberg, Raffaella Belvedere, Georg Rolshoven, Christa E. Müller, Michael Hölzel, Silvana Morello
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 165, Iss , Pp 115225- (2023)
CD73 is the key enzyme in the generation of extracellular adenosine, a mediator involved in tumor progression, tumor immune escape and resistance to anti-cancer therapeutics. Microenvironmental conditions influence the expression of CD73 in tumor cel
Externí odkaz:
https://doaj.org/article/2d01d7fab2754c648cad5647ebf10af7
Autor:
Julian P. Layer, Katharina Layer, Gustavo R. Sarria, Fred Röhner, Cas S. Dejonckheere, Lea L. Friker, Thomas Zeyen, David Koch, Davide Scafa, Christina Leitzen, Mümtaz Köksal, Frederic Carsten Schmeel, Niklas Schäfer, Jennifer Landsberg, Michael Hölzel, Ulrich Herrlinger, Matthias Schneider, Frank A. Giordano, Leonard Christopher Schmeel
Publikováno v:
Current Oncology, Vol 30, Iss 2, Pp 1300-1313 (2023)
Purpose: To determine the safety and outcome profile of five-fraction stereotactic radiotherapy (FSRT) for brain metastases (BM), either as a definitive or adjuvant treatment. Methods: We assessed clinical data of patients receiving five fractions of
Externí odkaz:
https://doaj.org/article/14acb167281c4e949dff21e05e773afc
Autor:
Roman Rüdiger, Franziska Geiser, Manuel Ritter, Peter Brossart, Mignon-Denise Keyver-Paik, Andree Faridi, Hartmut Vatter, Friedrich Bootz, Jennifer Landsberg, Jörg C. Kalff, Ulrich Herrlinger, Glen Kristiansen, Torsten Pietsch, Stefan Aretz, Daniel Thomas, Lukas Radbruch, Franz-Josef Kramer, Christian P. Strassburg, Maria Gonzalez-Carmona, Dirk Skowasch, Markus Essler, Matthias Schmid, Jennifer Nadal, Nicole Ernstmann, Amit Sharma, Benjamin Funke, Ingo G. H. Schmidt-Wolf
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-9 (2021)
Abstract Background Immigration has taken the central stage in world politics, especially in the developed countries like Germany, where the continuous flow of immigrants has been well documented since 1960s. Strikingly, emerging data suggest that mi
Externí odkaz:
https://doaj.org/article/4731b9fce47b41f2b9a7007a0942db2a
Autor:
Luka de Vos, Ingela Grünwald, Emma Grace Bawden, Jörn Dietrich, Kathrin Scheckenbach, Constanze Wiek, Romina Zarbl, Friedrich Bootz, Jennifer Landsberg, Dimo Dietrich
Publikováno v:
Epigenetics, Vol 15, Iss 11, Pp 1195-1212 (2020)
CTLA-4 blocking therapeutic antibodies are currently under investigation in head and neck squamous cell carcinoma (HNSCC). A better understanding of the epigenetic regulation of the CD28 superfamily members CD28, CTLA-4, and ICOS and their B7 ligands
Externí odkaz:
https://doaj.org/article/57166499a8bc49da998576e00116f167
Autor:
Dennis Niebel, Judith Sirokay, Friederike Hoffmann, Anne Fröhlich, Thomas Bieber, Jennifer Landsberg
Publikováno v:
Dermatology and Therapy, Vol 10, Iss 4, Pp 835-846 (2020)
Abstract Treatment of choice for nodular basal-cell carcinomas (BCCs) is complete excision, implying that small lesions are of minor concern. Metastasis is very rare (
Externí odkaz:
https://doaj.org/article/5257c0ee5e5246dabd7452bff1453cbf