Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jennifer Lachey"'
Autor:
Luigi Formicola, Alice Pannérec, Rosa Maria Correra, Barbara Gayraud-Morel, David Ollitrault, Vanessa Besson, Shahragim Tajbakhsh, Jennifer Lachey, Jasbir S. Seehra, Giovanna Marazzi, David A. Sassoon
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Degenerative myopathies typically display a decline in satellite cells coupled with a replacement of muscle fibers by fat and fibrosis. During this pathological remodeling, satellite cells are present at lower numbers and do not display a proper rege
Externí odkaz:
https://doaj.org/article/90eef81291cc42ec8c7a5ee2aaeac617
Autor:
Marcus D Goncalves, Emidio E Pistilli, Anthony Balduzzi, Morris J Birnbaum, Jennifer Lachey, Tejvir S Khurana, Rexford S Ahima
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12707 (2010)
Akt is a critical mediator of developmental skeletal muscle growth. Treatment with a soluble ActRIIB fusion protein (ActRIIB-mFc) increases skeletal muscle mass and strength by inhibiting myostatin and related peptides. Recent in vitro studies have s
Externí odkaz:
https://doaj.org/article/bc21d1f9959d4ec69839f3aba6af646d
Publikováno v:
Circulation. 144
Pulmonary arterial hypertension (PAH) is a debilitating disorder, characterized by right ventricle (RV) pressure overload, cardiac hypertrophy, and progressive RV dysfunction. PAH is associated with unbalanced TGFß signaling, favoring signaling of S
Autor:
Mark J. Alexander, Roselyne Castonguay, R. Scott Pearsall, M. Cannell, Lavanya Krishnan, Megan E. Troy, Jennifer Lachey, Monique V. Davies, Abigail E. Watanabe, Huiming Li, Jamie Strand, Katia Liharska, Samantha Wallner, Sarah Keates, Aaron W. Mulivor, Sako Dianne S, Ravi Kumar
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 368(3)
Follistatin is an endogenous glycoprotein that promotes growth and repair of skeletal muscle by sequestering inhibitory ligands of the transforming growth factor-β superfamily and may therefore have therapeutic potential for neuromuscular diseases.
Publikováno v:
Muscle & Nerve. 49:829-835
Introduction: Sensitive, non-invasive techniques are needed that can provide biomarkers of disease status and the effects of therapy in muscular dystrophy. Methods: We evaluated electrical impedance myography (EIM) to serve in this role by studying 2
Autor:
Jennifer Lachey, Kathryn W. Underwood, Matthew S. Spaits, Samuel M. Cadena, Kathleen N. Tomkinson, Ravindra Kumar, Travis E. Monnell, R. Scott Pearsall
Publikováno v:
Journal of Applied Physiology. 109:635-642
This is the first report that inhibition of negative regulators of skeletal muscle by a soluble form of activin type IIB receptor (ACE-031) increases muscle mass independent of fiber-type expression. This finding is distinct from the effects of selec
Autor:
Jeffrey Ucran, Ravindra Dhir, Sasha Bogdanovich, Jennifer Lachey, Emidio E. Pistilli, Xiaoyan Yin, Tejvir S. Khurana, Rexford S. Ahima, Imo Akpan, Marcus D. Goncalves
Publikováno v:
International journal of obesity (2005)
Myostatin, also known as Growth and Differentiation Factor 8, is a secreted protein that inhibits muscle growth. Disruption of myostatin signaling increases muscle mass and decreases glucose, but it is unclear whether these changes are related. We tr
Autor:
Joel K. Elmquist, Jennifer Lachey, Scott M. Sternson, Charlotte E. Lee, Carol F. Elias, Michael Scott, Jeffrey M. Friedman
Publikováno v:
The Journal of Comparative Neurology. 514:518-532
The central actions of leptin are essential for homeostatic control of adipose tissue mass, glucose metabolism, and many autonomic and neuroendocrine systems. In the brain, leptin acts on numerous different cell types via the long-form leptin recepto
Autor:
Todd D. Williams, Joel K. Elmquist, Amanda R. Waxman, Jeffrey M. Zigman, Juli E. Jones, Charlotte E. Lee, Yoshihide Nakano, Nina Balthasar, Bradford B. Lowell, Amy E. Deysher, Jennifer Lachey, Randy J. Seeley, Jacob Marcus, Roberto Coppari, Ryan D. White
Publikováno v:
Journal of Clinical Investigation. 115:3564-3572
Ghrelin is the endogenous ligand for the growth hormone secretagogue receptor (GHSR; ghrelin receptor). Since its discovery, accumulating evidence has suggested that ghrelin may play a role in signaling and reversing states of energy insufficiency. F
Autor:
Scott Pearsall, Raymond G. Hoffmann, Rachel V. Edelstein, Alan H. Beggs, Christopher R. Pierson, Lin Yang, Michael W. Lawlor, Fujun Liu, Anna Buj-Bello, Elizabeth J. Luna, Ke Yan, Marissa G. Viola, Cecilia J. Hillard, Alexandra Lerch-Gaggl, Hui Meng, Jennifer Lachey
Publikováno v:
Am J Pathol
Am J Pathol, 2014, 184 (6), pp.1831-42. ⟨10.1016/j.ajpath.2014.03.003⟩
Am J Pathol, 2014, 184 (6), pp.1831-42. ⟨10.1016/j.ajpath.2014.03.003⟩
International audience; X-linked myotubular myopathy is a congenital myopathy caused by deficiency of myotubularin. Patients often present with severe perinatal weakness, requiring mechanical ventilation to prevent death from respiratory failure. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f68a04cb846faeb1ee73a98ee024f7a2
https://hal.science/hal-02881169
https://hal.science/hal-02881169