Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jennifer L. Woodring"'
Autor:
Gautam Patel, Jessey Erath, Ana Rodriguez, Jennifer L. Woodring, Norma Roncal, Richard J. Sciotti, Baljinder Singh, Michael P. Pollastri, Erica Penn, Emanuele Amata, Amrita Sharma, Justin Wiedeman, Susan E. Leed, Paul J. Guyett, Ranjan Behera, Kojo Mensa-Wilmot
Publikováno v:
ACS Medicinal Chemistry Letters. 9:996-1001
[Image: see text] Discovery of new chemotherapeutic lead agents can be accelerated by optimizing chemotypes proven to be effective in other diseases to act against parasites. One such medicinal chemistry campaign has focused on optimizing the anilino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::423f29f906761c8401afba1b8b2fd9d8
https://doi.org/10.1021/acsmedchemlett.8b00245
https://doi.org/10.1021/acsmedchemlett.8b00245
Autor:
Kimberly G. Brady, Richard J. Sciotti, Mitchell F. Gallerstein, Jessey Erath, Jennifer L. Woodring, Kelly A. Bachovchin, Ana Rodriguez, Susan E. Leed, Kojo Mensa-Wilmot, Scott Tanghe, Michael P. Pollastri
Publikováno v:
European Journal of Medicinal Chemistry. 141:446-459
Human African trypanosomiasis (HAT) is a deadly disease in need of new chemotherapeutics that can cross into the central nervous system. We previously reported the discovery of 2 (NEU-617), a small molecule with activity against T. brucei bloodstream
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80ac3197a1f70ef8d9d7ab13e0674a32
https://doi.org/10.1016/j.ejmech.2017.10.007
https://doi.org/10.1016/j.ejmech.2017.10.007
Autor:
Jim-Min Fang, Ying-Ta Wu, Shao-Hung Lu, Jhih-Bin Chen, Chi-Huey Wong, Chiu-Chun Chou, Yi-Chou Huang, Jennifer L. Woodring, Yu-Hou Chen, Ming-Daw Tsai, Shih-Chi Wang, Ting-Jen R. Cheng, Larissa B. Krasnova
Publikováno v:
Journal of medicinal chemistry. 63(1)
Antiviral drug resistance in influenza infections has been a major threat to public health. To develop a broad-spectrum inhibitor of influenza to combat the problem of drug resistance, we previously identified the highly conserved E339...R416 salt br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb86acf222565308d5cc118867e853f5
https://pubmed.ncbi.nlm.nih.gov/31769665
https://pubmed.ncbi.nlm.nih.gov/31769665
Autor:
Jessey Erath, Patricia J. Lee, Kojo Mensa-Wilmot, Jennifer L. Woodring, Ranjan Behera, Ana Rodriguez, Richard J. Sciotti, Gautam Patel, Michael P. Pollastri, Susan E. Leed
Publikováno v:
MedChemComm. 6:339-346
Target repurposing is a proven method for finding new lead compounds that target Trypanosoma brucei, the causative agent of human African trypanosomiasis. Due to the recent discovery of a lapatinib-derived analog 2 with excellent potency against T. b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1770f9918d419c001bf12ce642108cce
https://doi.org/10.1039/c4md00441h
https://doi.org/10.1039/c4md00441h
Inhibitors of Protozoan Phosphodiesterases as Potential Therapeutic Approaches for Tropical Diseases
Publikováno v:
Phosphodiesterases and Their Inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65bfde274fc56f628691deaaac049b96
https://doi.org/10.1002/9783527682348.ch12
https://doi.org/10.1002/9783527682348.ch12
Autor:
Kimberly G. Brady, Mitchell F. Gallerstein, Michael P. Pollastri, Richard J. Sciotti, Scott Tanghe, Susan E. Leed, Kojo Mensa-Wilmot, Ana Rodriguez, Jessey Erath, Kelly A. Bachovchin, Jennifer L. Woodring
Publikováno v:
European Journal of Medicinal Chemistry. 152:515
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11d135cae55a1ff72f0d0531ede47ee8
https://doi.org/10.1016/j.ejmech.2018.05.002
https://doi.org/10.1016/j.ejmech.2018.05.002
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 32:1925-1933
A capillary electrophoresis method using terephthalate as probe ion in indirect photometric detection was investigated. The operating parameters including the pH and concentration of phosphate buffer, the applied potential, and the concentration of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b05331b62ecac22852d44468e63b11a
https://doi.org/10.1080/10826070903091621
https://doi.org/10.1080/10826070903091621
Autor:
Gautam Patel, Susan E. Leed, Emanuele Amata, Ana Rodriguez, Patricia J. Lee, Richard J. Sciotti, Norma Roncal, Jessey Erath, Jennifer L. Woodring, William G. Devine, Uma Swaminathan, Michael P. Pollastri, Kojo Mensa-Wilmot
Publikováno v:
Journal of Medicinal Chemistry
Tropical protozoal infections are a significant cause of morbidity and mortality worldwide; four in particular (human African trypanosomiasis (HAT), Chagas disease, cutaneous leishmaniasis, and malaria) have an estimated combined burden of over 87 mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::192cfe429caf97923c4ff44329d1666c
http://hdl.handle.net/20.500.11769/241477
http://hdl.handle.net/20.500.11769/241477
Autor:
Robert K. Campbell, Michael P. Pollastri, Jennifer L. Woodring, Nicholas D. Bland, Stefan O. Ochiana
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(21)
Human African trypanosomiasis (HAT) is a parasitic neglected tropical disease that affects 10,000 patients each year. Current treatments are sub-optimal, and the disease is fatal if not treated. Herein, we report our continuing efforts to repurpose t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7fd105b9ea1f9531782275ba723f427
https://pubmed.ncbi.nlm.nih.gov/24042005
https://pubmed.ncbi.nlm.nih.gov/24042005