Clinical validation of a blood-based classifier for diagnostic evaluation of asymptomatic individuals with pulmonary nodules

Autor: Charles E. Birse, Jennifer L. Tomic, Harvey I. Pass, William N. Rom, Robert J. Lagier

Publikováno v: Clinical Proteomics, Vol 14, Iss 1, Pp 1-9 (2017)

Abstract Background The number of pulmonary nodules detected in the US is expected to increase substantially following recent recommendations for nationwide CT-based lung cancer screening. Given the low specificity of CT screening, non-invasive adjuv

Externí odkaz: https://doaj.org/article/4312635bebfc45298f68f8b45708015f

Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction

Autor: Jennifer L. Tomic, Anna Pensalfini, Elizabeth Head, Charles G. Glabe

Publikováno v: Neurobiology of Disease, Vol 35, Iss 3, Pp 352-358 (2009)

Recent evidence has suggested a role for soluble oligomeric Aβ species in the pathology of Alzheimer's disease (AD). Fibrillar plaque deposits are present in non-demented individuals and levels of soluble Aβ correlate better with cognitive dysfunct

Externí odkaz: https://doaj.org/article/1b2b738ee8ea4acfa5f738f7c5a8e6e9

Conformation-Dependent Oligomers in Cerebrospinal Fluid of Presymptomatic Familial Alzheimer’s Disease Mutation Carriers

Autor: Giovanni Coppola, David Elashoff, Charles G. Glabe, Jennifer L. Tomic, John M. Ringman, Karen H. Gylys

Publikováno v: Dementia and Geriatric Cognitive Disorders Extra, Vol 2, Iss 1, Pp 652-657 (2012)
Dementia and Geriatric Cognitive Disorders EXTRA
Dementia and geriatric cognitive disorders extra, vol 2, iss 1

Background/Aims: Oligomerization of amyloid beta (Aβ) is a hypothesized step in the formation of plaques in Alzheimer’s disease (AD) but has been difficult to demonstrate in vivo in humans. As persons destined to develop familial AD (FAD) due to f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff1f3232b2aa96dc15387d96d290aab
https://doi.org/10.1159/000345771

Blood-based lung cancer biomarkers identified through proteomic discovery in cancer tissues, cell lines and conditioned medium

Autor: Charles E. Birse, Paul A. Moore, Tao He, Gulshan Dhariwal, Aiqun Li, Chad Danis, Jennifer L. Tomic, Mehdi Mesri, Erin Sult, James R. Jett, Eric S. Edell, Robert Lagier, Marcia Lewis, William N. Rom, William Fitzhugh, Fabien Maldonado, Jenny Heidbrink, Robert Bruce, Aaron O. Bungum, Harvey I. Pass, Elizabeth Joseloff, Steve Ruben

Publikováno v: Clinical Proteomics

Background Support for early detection of lung cancer has emerged from the National Lung Screening Trial (NLST), in which low-dose computed tomography (LDCT) screening reduced lung cancer mortality by 20 % relative to chest x-ray. The US Preventive S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb440a531d74c12f80f9f0af25a6a10
https://doi.org/10.1186/s12014-015-9090-9

Abstract 2813: Serum biomarker panel detects lung cancer in never smokers

Autor: Thomas Lenk, Steve Ruben, Robert Laiger, Charlie Birse, Jennifer L. Tomic, Robert Bruce

Publikováno v: Cancer Research. 71:2813-2813

Introduction: Lung cancer is the leading cause of cancer mortality worldwide with more than 1 million deaths each year. Although most lung cancers are attributable to smoking tobacco, it is estimated that as many as 25% of all lung cancer cases are i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e079b5b4c476c9c5cadab70852958c1
https://doi.org/10.1158/1538-7445.am2011-2813