Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Jennifer L. Shenk"'
Autor:
Roderick G. Davis, Emily A. Hull-Ryde, Jon L. Collins, Jennifer L. Shenk, James M. Lenhard, Thomas G. Consler, Julie B. Stimmel, Timothy M. Willson, Lisa M. Leesnitzer, Steven G. Blanchard, Jeff E. Cobb, Christina Therapontos, Lisa G. Patel, Derek J. Parks, Kelli D. Plunket, Randy K. Bledsoe
Publikováno v:
Biochemistry. 41:6640-6650
In the course of a high throughput screen to search for ligands of peroxisome proliferator activated receptor-gamma (PPARgamma), we identified GW9662 using a competition binding assay against the human ligand binding domain. GW9662 had nanomolar IC(5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd661a5d5f790806a3e2d39e9d4b42d1
https://doi.org/10.1021/bi0159581
https://doi.org/10.1021/bi0159581
Autor:
Shaoyong Chen, Christopher J. Fisher, Xiaofeng Zhou, Jennifer L. Shenk, Karl Tillman, Lirim Shemshedini
Publikováno v:
The Journal of biological chemistry. 276(42)
Prostate-specific antigen (PSA) is highly overexpressed in prostate cancer. One important regulator of PSA expression is the androgen receptor (AR), the nuclear receptor that mediates the biological actions of androgens. AR is able to up-regulate PSA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a5ecf110938983a9ee2c59f7d8e7bce
https://pubmed.ncbi.nlm.nih.gov/11504717
https://pubmed.ncbi.nlm.nih.gov/11504717
Autor:
Steven A. Kliewer, Marcos Luis Sznaidman, Timothy M. Willson, Barbara C. Hansen, Daniel D. Sternbach, Mike R. Snaith, Jennifer L. Shenk, Caroline S. Russell, Deborah A. Winegar, H. Eric Xu, Millard H. Lambert, William R. Oliver, Michael C. Lewis, Kelli D. Plunket, Noni L. Bodkin
The peroxisome proliferator-activated receptors (PPARs) are dietary lipid sensors that regulate fatty acid and carbohydrate metabolism. The hypolipidemic effects of the fibrate drugs and the antidiabetic effects of the glitazone drugs in humans are d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc7954aa6154bf60dfe64403f68bbad
https://europepmc.org/articles/PMC33205/
https://europepmc.org/articles/PMC33205/
Autor:
Nicholas C. O. Tomkinson, G. Bruce Wisely, John T. Moore, Timothy M. Willson, David D. McKee, Steven A. Kliewer, Millard H. Lambert, Stacey A. Jones, Geraldine A. Hamilton, Jennifer L. Shenk, Linda B. Moore, Edward L. LeCluyse
Publikováno v:
Molecular endocrinology (Baltimore, Md.). 14(1)
Transcription of genes encoding cytochrome P450 3A (CYP3A) monooxygenases is induced by a variety of xenobiotics and natural steroids. There are marked differences in the compounds that induce CYP3A gene expression between species. Recently, the mous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae88d8eff7c6e38940b06ef72afc2c47
https://pubmed.ncbi.nlm.nih.gov/10628745
https://pubmed.ncbi.nlm.nih.gov/10628745