Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Jennifer L. Rabe"'
Autor:
James S. Chavez, Jennifer L. Rabe, Katia E. Niño, Harrison H. Wells, Rachel L. Gessner, Taylor S. Mills, Giovanny Hernandez, Eric M. Pietras
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Chronic inflammation is a common feature of aging and numerous diseases such as diabetes, obesity, and autoimmune syndromes and has been linked to the development of hematological malignancy. Blood-forming hematopoietic stem cells (HSC) can contribut
Externí odkaz:
https://doaj.org/article/95336b6d9bfa4ee79efcfe80a9a8020f
Autor:
James S. Chavez, Jennifer L. Rabe, Giovanny Hernandez, Taylor S. Mills, Katia E. Niño, Pavel Davizon-Castillo, Eric M. Pietras
Publikováno v:
Cells, Vol 11, Iss 4, p 680 (2022)
The transcription factor PU.1 is a critical regulator of lineage fate in blood-forming hematopoietic stem cells (HSC). In response to pro-inflammatory signals, such as the cytokine IL-1β, PU.1 expression is increased in HSC and is associated with my
Externí odkaz:
https://doaj.org/article/b3e5fe7c3d834606a607973c9699bafb
Autor:
Giovanny Hernandez, Taylor S. Mills, Jennifer L. Rabe, James S. Chavez, Susan Kuldanek, Gregory Kirkpatrick, Leila Noetzli, Widian K. Jubair, Michelle Zanche, Jason R. Myers, Brett M. Stevens, Courtney J. Fleenor, Biniam Adane, Charles A. Dinarello, John Ashton, Craig T. Jordan, Jorge Di Paola, James R. Hagman, V. Michael Holers, Kristine A. Kuhn, Eric M. Pietras
Publikováno v:
Haematologica, Vol 105, Iss 3 (2020)
Rheumatoid arthritis (RA) is a debilitating autoimmune disease characterized by chronic inflammation and progressive destruction of joint tissue. It is also characterized by aberrant blood phenotypes including anemia and suppressed lymphopoiesis that
Externí odkaz:
https://doaj.org/article/eca59744a0444860b5057f8bf06972fb
Autor:
Daniel A. Pollyea, Chelsea Harris, Jennifer L. Rabe, Brenna R. Hedin, Lesly De Arras, Sigrid Katz, Emily Wheeler, Rafael Bejar, Matthew J. Walter, Craig T. Jordan, Eric M. Pietras, Scott Alper
Publikováno v:
Haematologica, Vol 104, Iss 9 (2019)
Externí odkaz:
https://doaj.org/article/f6dff924d9cf4929861865c44fb285b9
Autor:
Christopher C. Porter, Curtis J. Henry, Bhakti Dwivedi, Manali Rupji, Jill E. Slansky, Courtney L. Jones, Susan E. Zelasko, Susan P. Fosmire, Dmitry Baturin, Cathy Lee-Miller, Michael S. Leibowitz, Christy M. Gearheart, Jodi Dougan, Jairo A. Fonseca, Rae Hunter, Lori Gardner, Jennifer L. Rabe
Exploitation of the immune system has emerged as an important therapeutic strategy for acute lymphoblastic leukemia (ALL). However, the mechanisms of immune evasion during leukemia progression remain poorly understood. We sought to understand the rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e725aa270297026a7a76d30b3a1e122
https://doi.org/10.1158/0008-5472.c.6510962
https://doi.org/10.1158/0008-5472.c.6510962
Autor:
Pavel Davizon-Castillo, Eric M. Pietras, Taylor S. Mills, Jennifer L. Rabe, Katia E. Niño, Giovanny Hernandez, James S. Chavez
The transcription factor PU.1 is a critical regulator of lineage fate in blood-forming hematopoietic stem cells (HSC). In response to inflammatory signals, PU.1 expression is increased in HSC, activating myeloid differentiation genes while repressing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4acd997f6bffc0de5a3ed53c88c39f5e
https://doi.org/10.1101/2021.10.25.465758
https://doi.org/10.1101/2021.10.25.465758
Autor:
Jason R. Myers, Eric M. Pietras, Rachel L Gessner, Katia E. Niño, James DeGregori, Nouraiz Ahmed, Pavel Davizon-Castillo, James S. Chavez, Hyunmin Kim, Taylor S. Mills, Zhonghe Ke, Robert S. Welner, Brett M. Stevens, Timm Schroeder, Beau M Idler, Dirk Loeffler, Giovanny Hernandez, Kelly C. Higa, John M. Ashton, Craig T. Jordan, Hideaki Nakajima, Jennifer L. Rabe
Publikováno v:
Journal of Experimental Medicine, 218 (6)
The Journal of Experimental Medicine
The Journal of Experimental Medicine
Hematopoietic stem cells (HSCs) are capable of entering the cell cycle to replenish the blood system in response to inflammatory cues; however, excessive proliferation in response to chronic inflammation can lead to either HSC attrition or expansion.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c5f0deeced3592614adf5e265ef87c
https://hdl.handle.net/20.500.11850/480362
https://hdl.handle.net/20.500.11850/480362
Autor:
Etienne Danis, James DeGregori, Kelly C. Higa, Vadym Zaberezhnyy, Marco De Dominici, Daniel G. Tenen, James S. Chavez, Andrew Goodspeed, Eric M. Pietras, Jennifer L. Rabe
Publikováno v:
The Journal of Experimental Medicine
Higa et al. show that chronic interleukin-1β exposure primes multipotent hematopoietic progenitor cells for myelopoiesis by upregulating myeloid differentiation programs and repressing stem gene programs in a Cebpa-dependent manner. Consequently, in
Autor:
Zhonghe Ke, James DeGregori, Jason R. Myers, Robert S. Welner, Eric M. Pietras, Rachel L Gessner, Kelly C. Higa, Dirk Loeffler, Craig T. Jordan, Hideaki Nakajima, Beau M Idler, Taylor S. Mills, Jennifer L. Rabe, Giovanny Hernandez, Nouraiz Ahmed, John M. Ashton, Brett M. Stevens, James S. Chavez, Timm Schroeder, Hyunmin Kim
SummaryLoss of hematopoietic stem cell (HSC) quiescence and resulting clonal expansion are common initiating events in the development of hematological malignancy. Likewise, chronic inflammation related to aging, disease and/or tissue damage is assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a319b8016a4176f7c87f58e408e69246
https://doi.org/10.1101/2020.05.18.102830
https://doi.org/10.1101/2020.05.18.102830
Autor:
Kelly C. Higa, Andrew Goodspeed, James S. Chavez, Vadym Zaberezhnyy, Jennifer L. Rabe, Daniel G. Tenen, Eric M. Pietras, James DeGregori
The early events that drive hematologic disorders like clonal hematopoiesis, myelodysplastic syndrome, myeloproliferative neoplasm, and acute myeloid leukemia are not well understood. Most studies focus on the cell-intrinsic genetic changes that occu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::086fa09d344f8fb184a813b53bc5837b