Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jennifer L. Peotter"'
Acetyl-CoA flux from the cytosol to the ER regulates engagement and quality of the secretory pathway
Autor:
Inca A. Dieterich, Yusi Cui, Megan M. Braun, Alexis J. Lawton, Nicklaus H. Robinson, Jennifer L. Peotter, Qing Yu, Jason C. Casler, Benjamin S. Glick, Anjon Audhya, John M. Denu, Lingjun Li, Luigi Puglielli
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Nε-lysine acetylation in the ER is an essential component of the quality control machinery. ER acetylation is ensured by a membrane transporter, AT-1/SLC33A1, which translocates cytosolic acetyl-CoA into the ER lumen, and two acetyltransfer
Externí odkaz:
https://doaj.org/article/467b0be5ab394a82a7cfe0300b131b61
Autor:
Jennifer L. Peotter, Iryna Pustova, Molly M. Lettman, Shalini Shatadal, Mazdak M. Bradberry, Allison D. Winter-Reed, Maya Charan, Erin E. Sharkey, James R. Alvin, Alyssa M. Bren, Annika K. Oie, Edwin R. Chapman, M. Shahriar Salamat, Anjon Audhya
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Molecular pathways that intrinsically regulate neuronal maintenance are poorly understood, but rare pathogenic mutations that underlie neurodegenerative disease can offer important insights into the mechanisms that facilitate lifelong neuronal functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257be3c78887bd992d8f7f1afdaff0e5
https://doi.org/10.1073/pnas.2210649119
https://doi.org/10.1073/pnas.2210649119
Autor:
Jennifer A. Faralli, Harini Desikan, Donna M. Peters, Jennifer L. Peotter, Mark S. Filla, Abigail C. Wannow
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Fibronectin fibrillogenesis is an integrin-mediated process that may contribute to the pathogenesis of primary open-angle glaucoma (POAG). Here, we examined the effects of αvβ3 integrins on fibrillogenesis in immortalized TM-1 cells and hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::240abce67a888f857a64ac161b2ea0dd
http://europepmc.org/articles/PMC6750892
http://europepmc.org/articles/PMC6750892
Acetyl-CoA flux from the cytosol to the ER regulates engagement and quality of the secretory pathway
Autor:
Luigi Puglielli, Alexis J. Lawton, Jason C. Casler, Benjamin S. Glick, Anjon Audhya, Lingjun Li, Qing Yu, Megan M. Braun, Nicklaus H. Robinson, John M. Denu, Inca A. Dieterich, Jennifer L. Peotter, Yusi Cui
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Scientific Reports
Scientific Reports
Nε-lysine acetylation in the ER is an essential component of the quality control machinery. ER acetylation is ensured by a membrane transporter, AT-1/SLC33A1, which translocates cytosolic acetyl-CoA into the ER lumen, and two acetyltransferases, ATa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ebbe874faa0ede65df610d1e73c2dd3
https://doi.org/10.1038/s41598-021-81447-6
https://doi.org/10.1038/s41598-021-81447-6
Publikováno v:
Experimental Eye Research. 158:124-136
Integrins are a family of heterodimeric transmembrane receptors that mediate adhesion to the extracellular matrix (ECM). In addition to their role as adhesion receptors, integrins can act as ''bidirectional signal transducers'' that coordinate a larg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744596abaa1bfec76be208d044ab9fdd
https://doi.org/10.1016/j.exer.2016.05.011
https://doi.org/10.1016/j.exer.2016.05.011
Publikováno v:
Traffic
Coat proteins play multiple roles in the life cycle of a membrane-bound transport intermediate, functioning in lipid bilayer remodeling, cargo selection and targeting to an acceptor compartment. The Coat Protein complex II (COPII) coat is known to ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36374b2bdc246a2589d1063e6cc20d0a
https://pubmed.ncbi.nlm.nih.gov/31059169
https://pubmed.ncbi.nlm.nih.gov/31059169
Autor:
Scott M. Stagg, Iryna Pustova, Michael G. Hanna, Anjon Audhya, Kyle Quinney, Matthew C. Johnson, Adam Johnson, Jennifer Bird, Erin L. Slosarek, Jordan E. Burke, Amber L. Schuh, Samuel Block, E.B. Frankel, David A. Ruhl, Nilakshee Bhattacharya, Samuel E. Butcher, Edwin R. Chapman, Jennifer L. Peotter, Michael D. Sheets
Publikováno v:
Cell reports. 24(9)
Summary Length-dependent axonopathy of the corticospinal tract causes lower limb spasticity and is characteristic of several neurological disorders, including hereditary spastic paraplegia (HSP) and amyotrophic lateral sclerosis. Mutations in Trk-fus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd0b33dc81a2a5be13dce795fa5f159
https://pubmed.ncbi.nlm.nih.gov/30157421
https://pubmed.ncbi.nlm.nih.gov/30157421
Autor:
Jenny Phillips, Tiegang Tong, Donna M. Peters, Kaylee D. Dimeo, Jennifer L. Peotter, Jose M. Gonzalez
We previously demonstrated that an αvβ5 integrin/FAK- mediated pathway regulated the phagocytic properties of human trabecular meshwork (HTM) cells. Here we demonstrate that this process is mediated by Rac-1 and a previously unreported signaling pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93de934a2dd70530409aed82f134c633
https://europepmc.org/articles/PMC5333770/
https://europepmc.org/articles/PMC5333770/
