Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jennifer L. McClaren"'
Autor:
Susu Duan, Victoria A Meliopoulos, Jennifer L McClaren, Xi-Zhi J Guo, Catherine J Sanders, Heather S Smallwood, Richard J Webby, Stacey L Schultz-Cherry, Peter C Doherty, Paul G Thomas
Publikováno v:
PLoS Pathogens, Vol 11, Iss 2, p e1004642 (2015)
The recent emergence of a novel H7N9 influenza A virus (IAV) causing severe human infections in China raises concerns about a possible pandemic. The lack of pre-existing neutralizing antibodies in the broader population highlights the potential prote
Externí odkaz:
https://doaj.org/article/5588ffd71821403d9c3f2a7168f990b7
Autor:
Tracy J Ruckwardt, Allison M W Malloy, Emma Gostick, David A Price, Pradyot Dash, Jennifer L McClaren, Paul G Thomas, Barney S Graham
Publikováno v:
PLoS Pathogens, Vol 7, Iss 12, p e1002377 (2011)
Following respiratory syncytial virus infection of adult CB6F1 hybrid mice, a predictable CD8+ T cell epitope hierarchy is established with a strongly dominant response to a K(d)-restricted peptide (SYIGSINNI) from the M2 protein. The response to K(d
Externí odkaz:
https://doaj.org/article/55ead976929548608b5098c3ade7544c
Autor:
Jennifer L. McClaren, Shalini Sharma, Melissa Y. Morris, Paul G. Thomas, John A. Rutigliano, Peter C. Doherty, Thomas H. Oguin
Publikováno v:
Journal of Virology. 88:1636-1651
One question that continues to challenge influenza A research is why some strains of virus are so devastating compared to their more mild counterparts. We approached this question from an immunological perspective, investigating the CD8 + T cell resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccbb3a83b5365308e74ddbb207eb0805
https://doi.org/10.1128/jvi.02851-13
https://doi.org/10.1128/jvi.02851-13
Autor:
Alan Aderem, Carrie M. Rosenberger, Bart G. Jones, Peter C. Doherty, Jennifer L. McClaren, Pradyot Dash, Garnet Navarro, Catherine J. Sanders, Alan H. Diercks, Sherri L. Surman, Rebecca L. Podyminogin, Vincent C. Tam, Julia L. Hurwitz, Shari M. Kaiser, Jhoanna G. Noonan, Peter S. Askovich, Jacques J. Peschon, Paul G. Thomas
Publikováno v:
Journal of General Virology. 95:350-362
Type I alveolar epithelial cells are a replicative niche for influenza in vivo, yet their response to infection is not fully understood. To better characterize their cellular responses, we have created an immortalized murine lung epithelial type I ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::791e64a1f1a7382c0b41e7b176a1a25e
https://doi.org/10.1099/vir.0.058438-0
https://doi.org/10.1099/vir.0.058438-0
Autor:
Paul G. Thomas, Resha Bajracharya, Peter C. Doherty, Peter Vogel, Catherine J. Sanders, Jennifer L. McClaren
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology
During influenza virus infection, it is unclear how much alveolar cell loss can be tolerated before the host succumbs to the disease. We sought to define relevant correlates of disease severity in the mouse influenza model, hypothesizing that a susce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fcb62e40a9e36b3974a56b7f6810483
Autor:
Natalia A. Ilyushina, Robert G. Webster, Elena A. Govorkova, Jennifer L. McClaren, Bindumadhav M. Marathe
Publikováno v:
Journal of Virology. 84:8042-8050
The fitness of oseltamivir-resistant highly pathogenic H5N1 influenza viruses has important clinical implications. We generated recombinant human A/Vietnam/1203/04 (VN; clade 1) and A/Turkey/15/06 (TK; clade 2.2) influenza viruses containing the H274
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::201cf32e06a0c3cf904f1db4a4b2fa98
https://doi.org/10.1128/jvi.00689-10
https://doi.org/10.1128/jvi.00689-10
Autor:
T. S. P. Naipospos, Jennifer L. McClaren, Elena A. Govorkova, Natalia A. Ilyushina, Robert G. Webster, Bounlom Douangngeun
Publikováno v:
Antimicrobial Agents and Chemotherapy. 53:3088-3096
While the neuraminidase (NA) inhibitor oseltamivir is currently our first line of defense against a pandemic threat, there is little information about whether in vitro testing can predict the in vivo effectiveness of antiviral treatment. Using a pane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4025be7acaa5aad61f9d0b4acd05e6b
https://doi.org/10.1128/aac.01667-08
https://doi.org/10.1128/aac.01667-08
Publikováno v:
The Journal of Infectious Diseases. 197:1315-1323
Background. Current oseltamivir prophylactic regimens may not be as effective against highly pathogenic H5N1 influenza viruses as they are against less pathogenic strains. An optimal regimen is urgently needed. Methods. Ferrets were given the neurami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26615ff2e44664626496c0605e889045
https://doi.org/10.1086/586711
https://doi.org/10.1086/586711
Autor:
David S. Myers, Jennifer L. McClaren, Stephen B. Milne, H. Alex Brown, Paul G. Thomas, Pavlina T. Ivanova
Publikováno v:
ACS infectious diseases. 1(9)
While differences in the rate of virus fusion and budding from the host cell membrane have been correlated with pathogenicity, no systematic study of the contribution of differences in viral envelope composition has previously been attempted. Using r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8747fb2860637d34e42f315cbbd325ef
https://pubmed.ncbi.nlm.nih.gov/26448476
https://pubmed.ncbi.nlm.nih.gov/26448476
Autor:
Rachael Keating, Philip Bradley, Zachary S Wilson, Jennifer L. McClaren, Scott A. Brown, Benjamin A. Edwards, Hongbo Chi, Peter C. Doherty, Tomer Hertz, Maureen A. McGargill, Tarsha L. Harris, Julia L. Hurwitz, Paul G. Thomas, Sherri L. Surman, Marie Wehenkel
Publikováno v:
Nature immunology. 14(12)
Highly pathogenic avian influenza viruses pose a continuing global threat. Current vaccines will not protect against newly evolved pandemic viruses. The creation of 'universal' vaccines has been unsuccessful because the immunological mechanisms that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8544b82c77d1171ac345b225399acdfe
https://pubmed.ncbi.nlm.nih.gov/24240151
https://pubmed.ncbi.nlm.nih.gov/24240151