Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Jennifer L. McCann"'
Autor:
Diako Ebrahimi, Christopher M. Richards, Michael A. Carpenter, Jiayi Wang, Terumasa Ikeda, Jordan T. Becker, Adam Z. Cheng, Jennifer L. McCann, Nadine M. Shaban, Daniel J. Salamango, Gabriel J. Starrett, Jairam R. Lingappa, Jeongsik Yong, William L. Brown, Reuben S. Harris
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Human APOBEC3H has several haplotypes and splice variants with distinct anti-HIV-1 activities, but the genetics underlying the expression of these variants are unclear. Here, the authors identify an intronic deletion in A3H haplotype II resulting in
Externí odkaz:
https://doaj.org/article/ea3b48a2ed974a7c8e6b38190a93470e
Autor:
Daniel J. Salamango, Terumasa Ikeda, Seyed Arad Moghadasi, Jiayi Wang, Jennifer L. McCann, Artur A. Serebrenik, Diako Ebrahimi, Matthew C. Jarvis, William L. Brown, Reuben S. Harris
Publikováno v:
Cell Reports, Vol 29, Iss 5, Pp 1057-1065.e4 (2019)
Summary: HIV-1 Vif hijacks a cellular ubiquitin ligase complex to degrade antiviral APOBEC3 enzymes and PP2A phosphatase regulators (PPP2R5A–E). APOBEC3 counteraction is essential for viral pathogenesis. However, Vif also functions through an unkno
Externí odkaz:
https://doaj.org/article/c1e98fbb6c6d4901afc605ca1d57b854
Autor:
Gabriel J. Starrett, Artur A. Serebrenik, Pieter A. Roelofs, Jennifer L. McCann, Brandy Verhalen, Matthew C. Jarvis, Teneale A. Stewart, Emily K. Law, Annabel Krupp, Mengxi Jiang, John W. M. Martens, Ellen Cahir-McFarland, Paul N. Span, Reuben S. Harris
Publikováno v:
mBio, Vol 10, Iss 1 (2019)
ABSTRACT APOBEC3B is a single-stranded DNA cytosine deaminase with beneficial innate antiviral functions. However, misregulated APOBEC3B can also be detrimental by inflicting APOBEC signature C-to-T and C-to-G mutations in genomic DNA of multiple can
Externí odkaz:
https://doaj.org/article/3a082cd74ff645c9aabca1b686b2927e
Autor:
Gabriel J. Starrett, Elizabeth M. Luengas, Jennifer L. McCann, Diako Ebrahimi, Nuri A. Temiz, Robin P. Love, Yuqing Feng, Madison B. Adolph, Linda Chelico, Emily K. Law, Michael A. Carpenter, Reuben S Harris
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The APOBEC family of enzymes are cytidine deaminases with APOBEC3A and APOBEC3B thought to contribute to DNA damage signatures detected in cancer genomes. Here, the authors demonstrate an unappreciated role for APOBEC3H haplotype I in the generation
Externí odkaz:
https://doaj.org/article/341af74da85247c89f420036391ce4bf
Publikováno v:
Cell Reports, Vol 5, Iss 5, Pp 1256-1268 (2013)
The transition from transcription initiation into elongation is controlled by transcription factors, which recruit positive transcription elongation factor b (P-TEFb) to promoters to phosphorylate RNA polymerase II. A fraction of P-TEFb is recruited
Externí odkaz:
https://doaj.org/article/509277e06fa84781b81a5f58d0747807
Autor:
Pieter A Roelofs, Chai Yeen Goh, Boon Haow Chua, Matthew C Jarvis, Teneale A Stewart, Jennifer L McCann, Rebecca M McDougle, Michael A Carpenter, John WM Martens, Paul N Span, Dennis Kappei, Reuben S Harris
Publikováno v:
eLife, Vol 9 (2020)
APOBEC3B (A3B)-catalyzed DNA cytosine deamination contributes to the overall mutational landscape in breast cancer. Molecular mechanisms responsible for A3B upregulation in cancer are poorly understood. Here we show that a single E2F cis-element medi
Externí odkaz:
https://doaj.org/article/562661be3bbb4115a4d955575847fc12
Autor:
Reuben S. Harris, William L. Brown, Peter J. Parker, Rebecca M. McDougle, Michael B. Burns, Amy M. Molan, Elizabeth M. Luengas, Leah Kosyakovsky, Gabriel J. Starrett, Jennifer L. McCann, Brandon Leonard
Table S1. Cell Line Information. Table S2. ChIP reagents. Figure S1. APOBEC3B upregulation by PMA in multiple cell lines. Figure S2. APOBEC3 mRNA levels in PMA-treated MCF10A. Figure S3. Extended timecourse for PMA induction of APOBEC3B. Figure S4. V
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d9400e91e9c5f11670c586005110165
https://doi.org/10.1158/0008-5472.22404932
https://doi.org/10.1158/0008-5472.22404932
Autor:
Margaret R. Brown, Jae Jin Kim, Reuben S. Harris, Emily K. Law, Nuri A. Temiz, Shona Murphy, Natalia Gromak, Matthew C. Jarvis, Chiara Beghè, Kyle M. Miller, Michael A. Carpenter, Bojana Stefanovska, Jennifer L. McCann, Seo Yun Lee, Erik N. Bergstrom, Michael Tellier, Ludmil B. Alexandrov, Daniel J. Salamango, Agnese Cristini
The single-stranded DNA cytosine-to-uracil deaminase APOBEC3B is an antiviral protein implicated in cancer. However, its substrates in cells are not fully delineated. Here, APOBEC3B proteomics reveal interactions with a surprising number of R-loop fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::206e9463df57e84f390b995da13ba6ba
https://doi.org/10.1101/2021.08.30.458235
https://doi.org/10.1101/2021.08.30.458235
Autor:
Edyta Marcon, Nadine M. Shaban, Matthew C. Jarvis, Ivan Borozan, Jack Greenblatt, Natasha Malik-Soni, William L. Brown, Diako Ebrahimi, Adam Z. Cheng, Lori Frappier, Reuben S. Harris, Michael A. Carpenter, Jaime Yockteng-Melgar, Jennifer L. McCann
Publikováno v:
Nature Microbiology. 4:78-88
The apolipoprotein B messenger RNA editing enzyme, catalytic polypeptide-like (APOBEC) family of single-stranded DNA (ssDNA) cytosine deaminases provides innate immunity against virus and transposon replication1-4. A well-studied mechanism is APOBEC3
Autor:
Ramkumar Moorthy, Kayo Orellana, Ke Shi, Surajit Banerjee, Jennifer L. McCann, Lulu Yin, Reuben S. Harris, Nicholas H. Moeller, Daniel A. Harki, Michael A. Carpenter, Hideki Aihara
Publikováno v:
Proc Natl Acad Sci U S A
Spontaneous deamination of DNA cytosine and adenine into uracil and hypoxanthine, respectively, causes C to T and A to G transition mutations if left unrepaired. Endonuclease Q (EndoQ) initiates the repair of these premutagenic DNA lesions in prokary