Výsledky vyhledávání - "Jennifer L. Luongo"

Surrogate Antibodies That Specifically Bind and Neutralize CCL17 But Not CCL22

Autor: Ana Coelho, Tadas Panavas, Bingyuan Wu, Theodore Petley, Lester Gutshall, Jamie Fisher, Sandra Santulli-Marotto, Ken Boakye, Michael A. Rycyzyn, Cory M. Hogaboam, Jennifer L. Luongo, Karl Kavalkovich, Mary Ryan

Publikováno v: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 32:162-171

The chemokines CCL17 (TARC) and CCL22 (MDC) function through the same receptor, CCR4, but have been proposed to differentially affect the immune response. To better understand the role of the individual ligands, a panel of rat anti-mouse CCL17 surrog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46a2aa625f0098fb6e95e7535f408276
https://doi.org/10.1089/mab.2012.0112

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CCL22-specific Antibodies Reveal That Engagement of Two Distinct Binding Domains on CCL22 Is Required for CCR4-mediated Function

Autor: Sheng-Jiun Wu, Sandra Santulli-Marotto, John Wheeler, Jennifer L. Luongo, Eilyn R. Lacy, Ken Boakye, Mary Ryan

Publikováno v: Monoclonal antibodies in immunodiagnosis and immunotherapy. 34(6)

CCL22 inactivation in vivo occurs by cleavage at the N-terminus; however, it is unclear whether this encompasses the entire site of CCR4 interaction. CCL17 also binds CCR4 and its function requires binding via two discrete binding sites. Using monocl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f55538ab8af79020e6f34671585cd63c
https://pubmed.ncbi.nlm.nih.gov/26683175

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Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge

Autor: David M. Knight, Jennifer L. Luongo, Allison Oberholtzer, Diane D. Petrone, Tam Susan H, Omid Vafa, Randall J. Brezski, Robert Jordan, Gordon E. Powers, Mary Ryan

Publikováno v: Proceedings of the National Academy of Sciences. 106:17864-17869

The successful elimination of pathogenic cells and microorganisms by the humoral immune system relies on effective interactions between host immunoglobulins and Fcγ receptors on effector cells, in addition to the complement system. Essential Ig moti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a72cb520eba6c7f0177e4b34ca349fb
https://doi.org/10.1073/pnas.0904174106

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C1qRpdefines a new human stem cell population with hematopoietic and hepatic potential

Autor: Gary Butler, Guénahel H. Danet, Jennifer L. Luongo, M. Celeste Simon, Andrea J. Tenner, Dominique Bonnet, Min Min Lu

Publikováno v: Proceedings of the National Academy of Sciences. 99:10441-10445

The characterization of two distinct classes of hematopoietic stem cells based on CD34 expression and the ability of human bone marrow (BM) cells to differentiate into nonhematopoietic cells introduced new levels of complexity within the stem cell co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9370dcfbf98a5b3332ba56e15f249393
https://doi.org/10.1073/pnas.162104799

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Dissociation between stem cell phenotype and NOD/SCID repopulating activity in human peripheral blood CD34+ cells after ex vivo expansion

Autor: Hubert W. Lee, M. Celeste Simon, Jennifer L. Luongo, Guénahel H. Danet, Dominique Bonnet

Publikováno v: Experimental Hematology. 29:1465-1473

Objectives The relationship between phenotype and function in ex vivo–cultured human hematopoietic stem cells (HSC) remains poorly understood. We investigated the effects of a short-term serum-free culture on the relationship between stem cell phen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b260c8dabbe2f5a10e9d684c5ba2afb7
https://doi.org/10.1016/s0301-472x(01)00750-0

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Engagement of two distinct binding domains on CCL17 is required for signaling through CCR4 and establishment of localized inflammatory conditions in the lung

Autor: Ana Lucia Coelho, Jennifer L. Luongo, Mary Ryan, Sheng-Jiun Wu, Ken Boakye, Eilyn R. Lacy, Sandra Santulli-Marotto, Cory M. Hogaboam, Karl Kavalkovich

Publikováno v: PLoS ONE
PLoS ONE, Vol 8, Iss 12, p e81465 (2013)

CCL17 (TARC) function can be completely abolished by mAbs that block either one of two distinct sites required for CCR4 signaling. This chemokine is elevated in sera of asthma patients and is responsible for establishing inflammatory sites through CC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45772af8e7d4d1174eed875d57762e72
https://pubmed.ncbi.nlm.nih.gov/24339934

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Human anti-IgG1 hinge autoantibodies reconstitute the effector functions of proteolytically inactivated IgGs

Autor: Degang Zhong, Albert Schmidt, Robert Jordan, Susan H. Tam, David M. Knight, Marian Kruszynski, Diane D. Petrone, Mary Ryan, Randall J. Brezski, Brian Whitaker, Jennifer L. Luongo

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 181(5)

A number of proteases of potential importance to human physiology possess the ability to selectively degrade and inactivate Igs. Proteolytic cleavage within and near the hinge domain of human IgG1 yielded products including Fab and F(ab′)2 possessi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03784e821d73159d1f355c3d3dd54cff
https://pubmed.ncbi.nlm.nih.gov/18713989

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Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia

Autor: Ama Z. S. Rohatiner, T. Andrew Lister, Gwenn-ael Danet-Desnoyers, Jennifer L. Luongo, Dominique Bonnet, David Taussig, Daniel J. Pearce, Catherine Simpson, Gavin Kelly

Human hematopoietic stem cells (HSCs) are generally regarded as being devoid of the markers expressed by differentiated blood cells, the lineage-specific antigens. However, recent work suggests that genes associated with the myeloid lineage are trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4b24b51c3c3bf8cc262b5b6bfbe161
https://europepmc.org/articles/PMC1895250/

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Telomerase vaccination has no detectable effect on SCID-repopulating and colony-forming activities in the bone marrow of cancer patients

Autor: Susan M. Domchek, Gwenn-ael Danet-Desnoyers, Jennifer L. Luongo, Dominique Bonnet, Robert H. Vonderheide

Publikováno v: Experimental hematology. 33(11)

Objectives The telomerase reverse transcriptase hTERT is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytes (CTL). We have previously shown that vaccination of cancer patients against hTERT induces functional anti-tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37c79556e35c7c617705ab890380c330
https://pubmed.ncbi.nlm.nih.gov/16263411

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