Výsledky vyhledávání - "Jennifer L. Lippens"

Akademický článek

TransExION: a transformer based explainable similarity metric for comparing IONS in tandem mass spectrometry

Autor: Danh Bui-Thi, Youzhong Liu, Jennifer L. Lippens, Kris Laukens, Thomas De Vijlder

Publikováno v: Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-14 (2024)

Abstract Small molecule identification is a crucial task in analytical chemistry and life sciences. One of the most commonly used technologies to elucidate small molecule structures is mass spectrometry. Spectral library search of product ion spectra

Externí odkaz: https://doaj.org/article/73ad185aefad4f4d9acc13963584d7e1

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MeRgeION : a multifunctional R pipeline for small molecule LC-MS/MS data processing, searching, and organizing

Autor: Youzhong Liu, Yingjie Zhang, Tom Vennekens, Jennifer L. Lippens, Luc Duijsens, Danh Bui-Thi, Kris Laukens, Thomas de Vijlder

Publikováno v: Analytical chemistry

Small molecule structure elucidation using tandem mass spectrometry (MS/MS) plays a crucial role in life science, bioanalytical, and pharmaceutical research. There is a pressing need for increased throughput of compound identification and transformat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c6fd1060623cbad99ec95337dc3a54
https://hdl.handle.net/10067/1968220151162165141

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High-Throughput Mass Spectrometry for Biopharma: A Universal Modality and Target Independent Analytical Method for Accurate Biomolecule Characterization

Autor: Iain D. G. Campuzano, Emma M. Pelegri-O’Day, Nithya Srinivasan, Jennifer L. Lippens, Pascal Egea, Aiko Umeda, Jennifer Aral, Tianqi Zhang, Arthur Laganowsky, Chawita Netirojjanakul

Publikováno v: Journal of the American Society for Mass Spectrometry. 33(11)

Reversed-phase liquid chromatographic mass spectrometry (rpLC-MS) is a universal, platformed, and essential analytical technique within pharmaceutical and biopharmaceutical research. Typical rpLC method gradient times can range from 5 to 20 min. As m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ef181e1f10aa073828eb56f4487665
https://pubmed.ncbi.nlm.nih.gov/36206542

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Native and Denaturing MS Protein Deconvolution for Biopharma: Monoclonal Antibodies and Antibody–Drug Conjugates to Polydisperse Membrane Proteins and Beyond

Autor: John O. Hui, Stone D.-H. Shi, Pascal F. Egea, John H. Robinson, Jennifer L. Lippens, Michael Nshanian, Dhanashri Bagal, Joseph A. Loo, Marshall Bern, Chawita Netirojjanakul, Iain D. G. Campuzano

Publikováno v: Analytical chemistry, vol 91, iss 15
Anal Chem

Electrospray ionization mass spectrometry (ESI-MS) is a ubiquitously used analytical method applied across multiple departments in biopharma, ranging from early research discovery to process development. Accurate, efficient, and consistent protein MS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f7aaae0becae8f11e2aee4a6b6824f5
https://doi.org/10.1021/acs.analchem.9b00062

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Rapid LC–MS Method for Accurate Molecular Weight Determination of Membrane and Hydrophobic Proteins

Autor: Iain D. G. Campuzano, Pascal F. Egea, James E. Keener, Amit Vaish, Michael T. Marty, Joseph A. Loo, Jennifer L. Lippens, Chris Spahr

Publikováno v: Analytical Chemistry. 90:13616-13623

Therapeutic target characterization involves many components, including accurate molecular weight (MW) determination. Knowledge of the accurate MW allows one to detect the presence of post-translational modifications, proteolytic cleavages, and impor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc58a913543e91a79489705f50ff8cfc
https://doi.org/10.1021/acs.analchem.8b03843

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Native-MS Analysis of Monoclonal Antibody Conjugates by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Autor: Steven L. Van Orden, Iain Campuzano, Joseph A. Loo, Jennifer L. Lippens, Michael Nshanian, Chawita Netirojjanakul, David P. A. Kilgour

Publikováno v: Analytical Chemistry. 90:745-751

Antibody drug conjugates (ADCs) are an important class of therapeutic molecule currently being used to treat HER2-positive metastatic breast cancer, relapsed or refractory Hodgkin lymphoma, systemic anaplastic large cell lymphoma, relapsed or refract

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0021c5f9e4b3ea2b483eda4b2cdc88b1
https://doi.org/10.1021/acs.analchem.7b03021

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Native MS Analysis of Bacteriorhodopsin and an Empty Nanodisc by Orthogonal Acceleration Time-of-Flight, Orbitrap and Ion Cyclotron Resonance

Autor: Juraj Svitel, Han Xu, Jennifer L. Lippens, Joseph A. Loo, Robert J. M. Kurzeja, Iain Campuzano, Dhanashri Bagal, Paul D. Schnier, Huilin Li

Publikováno v: Analytical Chemistry. 88:12427-12436

Over the past two decades orthogonal acceleration time-of-flight has been the de facto analyzer of choice for solution and membrane soluble protein native mass spectrometry (MS) studies; this however is gradually changing. Here we compare three MS in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6a76b641858679d87bb981caae8ad5
https://doi.org/10.1021/acs.analchem.6b03762

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Best practices and benchmarks for intact protein analysis for top-down mass spectrometry

Publikováno v: Nature methods, vol 16, iss 7
Nature Methods
Nature Methods, Nature Publishing Group, 2019, 16 (7), pp.587-594. ⟨10.1038/s41592-019-0457-0⟩
Nature Methods, 2019, 16 (7), pp.587-594. ⟨10.1038/s41592-019-0457-0⟩

One gene can give rise to many functionally distinct proteoforms, each of which has a characteristic molecular mass. Top-down mass spectrometry enables the analysis of intact proteins and proteoforms. Here members of the Consortium for Top-Down Prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f4d2ff753f4535711f739a1916ff31f
https://escholarship.org/uc/item/72c7s81j

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A simple heated-capillary modification improves the analysis of non-covalent complexes by Z-spray electrospray ionization

Autor: Bill Redick, Jennifer L. Lippens, J. B. Mangrum, Daniele Fabris, William McIntyre

Publikováno v: Rapid Communications in Mass Spectrometry. 30:773-783

RATIONALE The observation of intact non-covalent complexes by electrospray ionization mass spectrometry (ESI-MS) hinges on the ability to minimize in-source activation processes that take place during analyte desolvation. We explored the merits of re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8361774d2cbd9afc3c2e4ec662028238
https://doi.org/10.1002/rcm.7490

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Modular calibrant sets for the structural analysis of nucleic acids by ion mobility spectrometry mass spectrometry

Autor: Jennifer L. Lippens, Daniele Fabris, Srivathsan V. Ranganathan, Rebecca J. D’Esposito

Publikováno v: The Analyst. 141:4084-4099

This study explored the use of modular nucleic acid (NA) standards to generate calibration curves capable of translating primary ion mobility readouts into corresponding collision cross section (CCS) data. Putative calibrants consisted of single- (ss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd3b030d23fb939f80022ed2b9504f6
https://doi.org/10.1039/c6an00453a

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