Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jennifer L. Illuzzi"'
Autor:
Jennifer L Illuzzi, Nicole A Harris, Brittney A Manvilla, Daemyung Kim, Mengxia Li, Alexander C Drohat, David M Wilson
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65922 (2013)
Apurinic/apyrimidinic endonuclease 1 (APE1) is the predominant AP site repair enzyme in mammals. APE1 also maintains 3'-5' exonuclease and 3'-repair activities, and regulates transcription factor DNA binding through its REF-1 function. Since complete
Externí odkaz:
https://doaj.org/article/ca95f19d63ee4dd6bcc755cc748ad470
Autor:
Jennifer L. Illuzzi, Bret D. Freudenthal, A.M. Whitaker, Peter J. McKinnon, Daniel R. McNeill, Wesley J. Stark, David M. Wilson
Publikováno v:
Mutagenesis
DNA is susceptible to a range of chemical modifications, with one of the most frequent lesions being apurinic/apyrimidinic (AP) sites. AP sites arise due to damage-induced (e.g. alkylation) or spontaneous hydrolysis of the N-glycosidic bond that link
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5e0fc1d941281f3e445296b98c06b02
https://europepmc.org/articles/PMC7016205/
https://europepmc.org/articles/PMC7016205/
Autor:
Daniel R. McNeill, David M. Wilson, Paul Bastian, Kevin G. Becker, Helen R. Russell, Peter J. McKinnon, Jennifer L. Illuzzi, Boris M. Brenerman, Fred Bunz, Robert P. Wersto
Publikováno v:
Environmental and Molecular Mutagenesis. 58:84-98
Base excision repair (BER) is the major pathway for coping with most forms of endogenous DNA damage, and defects in the process have been associated with carcinogenesis. Apurinic/apyrimidinic endonuclease 1 (APE1) is a central participant in BER, fun
Autor:
Jennifer L. Illuzzi, Helen R. Russell, Peter J. McKinnon, David M. Wilson, Yang Li, Susanna M. Downing, Mikio Shimada, Young-Don Kwak, Lavinia C. Dumitrache
Frequent oxidative modification of the neural genome is a by-product of the high oxygen consumption of the nervous system. Rapid correction of oxidative DNA lesions is essential, as genome stability is a paramount determinant of neural homeostasis. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b474dc5b1e438915ad7625d9aa4dea
https://europepmc.org/articles/PMC6310806/
https://europepmc.org/articles/PMC6310806/
Publikováno v:
Carcinogenesis. 35:2643-2652
Base excision repair (BER) is a frontline defense mechanism for dealing with many common forms of endogenous DNA damage, several of which can drive mutagenic or cell death outcomes. The pathway engages proteins such as glycosylases, abasic endonuclea
Autor:
Alexander D. Rowe, Linda Møllersen, Jennifer L. Illuzzi, Anja Bjølgerud, Gunn A. Hildrestrand, Magnar Bjørås, Arne Klungland, Katharina J. Gerhold, Linda Tveterås, David M. Wilson
Publikováno v:
Human Molecular Genetics
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by trinucleotide repeat (TNR) expansions. We show here that somatic TNR expansions are significantly reduced in several organs of R6/1 mice lacking exon 2 of Nei-like 1 (Nei
Autor:
Michel Bernier, Yun Jeong Kim, Michael L. Gross, Dian Su, Jennifer L. Illuzzi, Daemyung Kim, David M. Wilson, Millie M. Georgiadis, Sarah Delaplane
Publikováno v:
Journal of Molecular Biology. 414:313-326
Human apurinic/apyrimidinic (AP) endonuclease 1 (APE1) is a central participant in the base excision repair pathway, exhibiting AP endonuclease activity that incises the DNA backbone 5′ to an abasic site. Besides its prominent role as a DNA repair
Autor:
David M. Wilson, Dorjbal Dorjsuren, Oscar M. Rueda, Stephen Chan, Vivek Mohan, Abhik Mukherjee, Ian O. Ellis, Nada Albarakati, Jennifer L. Illuzzi, Carlos Caldas, Tarek M. A. Abdel-Fatah, Rachel Abbotts, Paul M. Moseley, Srinivasan Madhusudan, Roslin Russell, Hongmao Sun, Graham Ball, Devika Agarwal, David J. Maloney, Ajit Jadhav, Anton Simeonov
Publikováno v:
Molecular oncology, vol 8, iss 7
FEN1 has key roles in Okazaki fragment maturation during replication, long patch base excision repair, rescue of stalled replication forks, maintenance of telomere stability and apoptosis. FEN1 may be dysregulated in breast and ovarian cancers and ha
Autor:
Jennifer L. Illuzzi, David M. Wilson
Cancer treatments often lose their effectiveness due to the development of multiple drug resistance. Thus, identification of key proteins involved in the tumorigenic process and the survival mechanism(s), coupled with the design of novel therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd80553dab04cb9078074e54c83bfa43
https://europepmc.org/articles/PMC4537170/
https://europepmc.org/articles/PMC4537170/
Publikováno v:
Journal of molecular neuroscience : MN. 45(2)
Huntington's disease (HD) occurs through an expansion of the trinucleotide repeat in the HD gene resulting in the lengthening of the polyglutamine stretch within the N terminus of the protein, huntingtin (Htt). While the function of the protein is st