Výsledky vyhledávání - "Jennifer L. Hoover"

Akademický článek

Expert workshop summary: Advancing toward a standardized murine model to evaluate treatments for antimicrobial resistance lung infections

Autor: Rakel Arrazuria, Bernhard Kerscher, Karen E. Huber, Jennifer L. Hoover, Carina Vingsbo Lundberg, Jon Ulf Hansen, Sylvie Sordello, Stephane Renard, Vincent Aranzana-Climent, Diarmaid Hughes, Philip Gribbon, Lena E. Friberg, Isabelle Bekeredjian-Ding

Publikováno v: Frontiers in Microbiology, Vol 13 (2022)

The rise in antimicrobial resistance (AMR), and increase in treatment-refractory AMR infections, generates an urgent need to accelerate the discovery and development of novel anti-infectives. Preclinical animal models play a crucial role in assessing

Externí odkaz: https://doaj.org/article/4b5b6c8d81a04eadbeb5ed8b76a1c875

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Akademický článek

Variability of murine bacterial pneumonia models used to evaluate antimicrobial agents

Publikováno v: Frontiers in Microbiology, Vol 13 (2022)

Antimicrobial resistance has become one of the greatest threats to human health, and new antibacterial treatments are urgently needed. As a tool to develop novel therapies, animal models are essential to bridge the gap between preclinical and clinica

Externí odkaz: https://doaj.org/article/cee7cdc3abe644f0b3323bf66538e83e

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Multimodal imaging distribution assessment of a liposomal antibiotic in an infectious disease model

Autor: Shih-Hsun Cheng, M. Reid Groseclose, Cindy Mininger, Mats Bergstrom, Lily Zhang, Stephen C. Lenhard, Tinamarie Skedzielewski, Zachary D. Kelley, Debra Comroe, Hyundae Hong, Haifeng Cui, Jennifer L. Hoover, Steve Rittenhouse, Stephen Castellino, Beat M. Jucker, Hasan Alsaid

Publikováno v: Journal of Controlled Release. 352:199-210

Liposomes are promising targeted drug delivery systems with the potential to improve the efficacy and safety profile of certain classes of drugs. Though attractive, there are unique analytical challenges associated with the development of liposomal d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::808389d84f76ac5b6484f9589b96e505
https://doi.org/10.1016/j.jconrel.2022.08.061

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Dose Selection for Phase III Clinical Evaluation of Gepotidacin (GSK2140944) in the Treatment of Uncomplicated Urinary Tract Infections

Autor: Nicole E. Scangarella-Oman, Mohammad Hossain, Jennifer L. Hoover, Caroline R. Perry, Courtney Tiffany, Aline Barth, Etienne F. Dumont

Publikováno v: Antimicrobial Agents and Chemotherapy. 66

Antibiotics are the current standard-of-care treatment for uncomplicated urinary tract infections (uUTIs). However, increasing rates of bacterial antibiotic resistance necessitate novel therapeutic options. Gepotidacin is a first-in-class triazaacena

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4472caadab4e640a7197d4fb561cb906
https://doi.org/10.1128/aac.01492-21

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Remodeling and Neointimal Formation in the Carotid Artery of Normal and P-Selectin–Deficient Mice

Autor: Volkhard Lindner, Anjali Kumar, Ronald J. Shebuski, Carol A. Simmons, Jennifer L. Hoover

Publikováno v: Circulation. 96:4333-4342

Background Inflammatory reactions such as leukocyte activation with platelet adherence and release of inflammatory mediators occur after percutaneous transluminal coronary angioplasty and may play a role in restenosis. Vascular remodeling with neoint

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f40f9a0c68cdc080c025abd34a0dc726
https://doi.org/10.1161/01.cir.96.12.4333

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