Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jennifer L. Hellawell"'
Autor:
Uma Sinha, Rick Lumpkin, Jonathan C. Fox, Jennifer L. Hellawell, Jesper Jernelius, Terry O'Reilly, Daniel D. Gretler, Satish Rao
Publikováno v:
Clinical Pharmacology in Drug Development
AG10 is a novel, potent, and selective oral transthyretin (TTR) stabilizer being developed to treat TTR amyloidosis (ATTR). This randomized, double‐blind, placebo‐controlled study evaluated safety, tolerability, pharmacokinetics, and pharmacodyna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a58ea47f939f79591238a6da2b62ca
https://doi.org/10.1002/cpdd.700
https://doi.org/10.1002/cpdd.700
Publikováno v:
Expert Opinion on Drug Metabolism & Toxicology. 10:1445-1453
This review summarizes current information on the first oral prostanoid approved for treatment of pulmonary arterial hypertension, treprostinil diolamine , which, similar to other prostacyclin analogs, vasodilates, impacts remodeling (antiproliferati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e42f0fe9c4c0ed0b8684fa98820f06f9
https://doi.org/10.1517/17425255.2014.958466
https://doi.org/10.1517/17425255.2014.958466
Autor:
Jennifer L. Hellawell, Raffaele Coppini, Jonathan Myers, Christiana Blair, Martin S. Maron, Ramin Farzaneh-Far, Luiz Belardinelli, Iacopo Olivotto
Publikováno v:
Circulation: Heart Failure. 9
Abstract— Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disorder, with an overall prevalence of at least 1:500 in the adult population although only a fraction of affected patients come to clinical recognition. It is also t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634d9b96eeeeda2dd58c37f94d370ae6
https://doi.org/10.1161/circheartfailure.115.002764
https://doi.org/10.1161/circheartfailure.115.002764
Autor:
Amr E. Abbas, Sahar S. Abdelmoneim, Theodore Abraham, Harry Acquatella, David B. Adams, Karima Addetia, Jonathan Afilalo, Vikram Agarwal, Yoram Agmon, Mohamed Ahmed, Carlos Alviar, Bonita Anderson, Edgar Argulian, Federico M. Asch, Gerard P. Aurigemma, Kelly Axsom, Luigi P. Badano, Revathi Balakrishnan, Sourin Banerji, Sripal Bangalore, Manish Bansal, Thomas Bartel, Rebecca Lynn Baumann, Helmut Baumgartner, Roy Beigel, J. Todd Belcik, Marek Belohlavek, Ricardo Benenstein, Eric Berkowitz, Nicole M. Bhave, Angelo Biviano, Nimrod Blank, Robert O. Bonow, Darryl J. Burstow, Benjamin Byrd, Scipione Carerj, John D. Carroll, Scott Chadderdon, Hari P. Chaliki, Kwan-Leung Chan, Farooq A. Chaudhry, Geoff Chidsey, Sofia Churzidse, Blai Coll, Vivian W. Cui, Maurizio Cusma-Picconne, Abdellaziz Dahou, Jacob P. Dal-Bianco, Daniel A. Daneshvar, Melissa A. Daubert, Ravin Davidoff, Jeanne M. DeCara, Antonia Delgado-Montero, Lisa Dellefave-Castillo, Ankit A. Desai, Kavit A. DeSouza, Bryan Doherty, Robert Donnino, Pamela S. Douglas, David M. Dudzinski, Raluca Dulgheru, Jean G. Dumesnil, Uri Elkayam, Raimund Erbel, Francine Erenberg, Arturo A. Evangelista, Steven B. Feinstein, Beatriz Ferreira, Elyse Foster, Benjamin H. Freed, Julius M. Gardin, Edward A. Gill, Linda Gillam, Steven Giovannone, Mark Goldberger, Steven A. Goldstein, John Gorcsan, Riccardo Gorla, Julia Grapsa, Erin S. Grawe, Christiane Gruner, Pooja Gupta, Swaminatha Gurudevan, Rebecca T. Hahn, Yuchi Han, Jennifer L. Hellawell, Samuel D. Hillier, Brian D. Hoit, Richard Humes, Vikrant Jagadeesan, Sonia Jain, Alexander Janosi, Peter A. Kahn, Sanjiv Kaul, Bijoy K. Khandheria, Gene H. Kim, Michael S. Kim, Bruce J. Kimura, Mary Etta King, Dmitry Kireyev, James N. Kirkpatrick, Allan L. Klein, Payal Kohli, Claudia E. Korcarz, Smadar Kort, Wojciech Kosmala, Konstantinos Koulogiannis, Ilias Koutsogeorgis, Frederick W. Kremkau, Eric V. Krieger, Itzhak Kronzon, Richard T. Kutnick, Wyman Lai, Stephane Lambert, Patrizio Lancellotti, Roberto M. Lang, Alex Pui-Wai Lee, Ming Sum Lee, Stamatios Lerakis, Jonathan Lessick, Steven J. Lester, Steve W. Leung, Florent LeVen, Robert A. Levine, Qin Li, Fabio Lima, Jonathan R. Lindner, Leo Lopez, Julien Magne, Haifa Mahjoub, Judy R. Mangion, Sunil V. Mankad, Dimitrios Maragiannis, Leo Marcoff, Randolph P. Martin, Thomas H. Marwick, Pierre Massabuau, Moses Mathur, Robert McCully, Edwin C. McGee, Elizabeth McNally, Sudhir Ken Mehta, Todd Mendelson, Issam A. Mikati, Karen Modesto, Mark Monaghan, Farouk Mookadam, Marie Moonen, Monica Mukherjee, Silvana Müller, Sharon L. Mulvagh, Denisa Muraru, Gillian Murtagh, Sherif F. Nagueh, Tasneem Z. Naqvi, Sandeep Nathan, Kazuaki Negishi, Petros Nihoyannopoulos, Vuyisile T. Nkomo, Erwin Oechslin, Joan Olson, John Palios, Gaurav Parikh, Amit R. Patel, Amit V. Patel, Aneet Patel, Anupa Patel, Timothy E. Paterick, Laila A. Payvandi, Gianni Pedrizzetti, Patricia A. Pellikka, Gila Perk, Ferande Peters, Dermot Phelan, Philippe Pibarot, Michael H. Picard, Juan Carlos Plana, Zoran B. Popovic, Thomas Porter, Shawn C. Pun, Atif N. Qasim, Nishath Quader, Miguel A. Quinones, Peter S. Rahko, Harry Rakowski, Rajeev V. Rao, Joseph Reiken, Shimon A. Reisner, Elizabeth M. Retzer, Vera H. Rigolin, David A. Roberson, Keith Rodgers, Damian Roper, Raphael Rosenhek, Eleanor Ross, R. Raina Roy, Frederick L. Ruberg, Lawrence G. Rudski, Carlos Ruiz, Ernesto E. Salcedo, Danita M. Yoerger Sanborn, Vrinda Sardana, Muhamed Saric, Nelson B. Schiller, Arend F.L. Schinkel, Shmuel S. Schwartzenberg, Partho P. Sengupta, Pravin M. Shah, Jack S. Shanewise, Stanton K. Shernan, Jeffrey A. Shih, Robert J. Siegel, Maithri Siriwardena, Samuel Siu, Scott D. Solomon, Vincent L. Sorrell, Kirk T. Spencer, Denise Spiegel, Martin St. John Sutton, James H. Stein, Kathleen Stergiopoulos, Azhar A. Supariwala, Paul E. Szmitko, Tanya H. Tajouri, Masaaki Takeuchi, Timothy C. Tan, James D. Thomas, Dennis A. Tighe, Maria C. Todaro, Albree Tower-Rader, Michael Y.C. Tsang, Teresa S.M. Tsang, Wendy Tsang, Paul A. Tunick, Philippe Vignon, Meagan M. Wafsy, Rachel Wald, R. Parker Ward, Nozomi Watanabe, Kevin Wei, Neil J. Weissman, Mariko Welsch, Susan Wiegers, Lynne Williams, Anna Woo, Chanwit Wuttichaipradit, Feng Xie, Teerapat Yingchoncharoen, Cheuk-Man Yu, Zoe Yu, Qiong Zhao, Concetta Zito, William A. Zoghbi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77a437a25f45e78e8501b3a81288414e
https://doi.org/10.1016/b978-0-323-26011-4.09994-0
https://doi.org/10.1016/b978-0-323-26011-4.09994-0
Publikováno v:
Cardiovascular Therapeutics. 30:172-181
Despite an extensive literature defining the mechanisms and significance of pathological myocardial remodeling, there has been no comprehensive review of the inverse process, often labeled reverse remodeling. Accordingly, the goal of this review is t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac1bd7da33919bec8ce45d6dd958ffeb
https://doi.org/10.1111/j.1755-5922.2010.00247.x
https://doi.org/10.1111/j.1755-5922.2010.00247.x
Autor:
Christopher F. Liu, Sei Iwai, Jennifer L. Hellawell, Jim W. Cheung, Kenneth M. Stein, James E. Ip, David Park, Bruce B. Lerman, Steven M. Markowitz
Publikováno v:
Journal of Cardiovascular Electrophysiology. 22:293-299
Volume Overload and Ventricular Arrhythmias. Background: Acute exacerbations of heart failure (HF) are believed to trigger malignant ventricular arrhythmias, but the temporal association between fluid accumulation and ventricular arrhythmias has not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b5dede2c3fbe8bef24bb4735a5ea53f
https://doi.org/10.1111/j.1540-8167.2010.01924.x
https://doi.org/10.1111/j.1540-8167.2010.01924.x
Autor:
Caroline B. Kensler, Gergely Szakács, Henry M. Fales, Jennifer L. Hellawell, David E. Hibbs, Joseph A. Ludwig, Matthew D. Hall, Michael M. Gottesman, Noeris K. Salam
Publikováno v:
Journal of Medicinal Chemistry. 52:3191-3204
We have recently identified a new class of compounds that selectively kill cells that express P-glycoprotein (P-gp, MDR1), the ATPase efflux pump that confers multidrug resistance on cancer cells. Several isatin-beta-thiosemicarbazones from our initi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e92f51520f80a92dc6c71a2a5d71e9cb
https://doi.org/10.1021/jm800861c
https://doi.org/10.1021/jm800861c
Publikováno v:
The American journal of cardiology. 117(10)
Hypertrophic cardiomyopathy (HC) is the most common genetic heart disease and an important cause of sudden death and heart failure symptoms. The current prevalence for HC (1:500) is based on echocardiographic population studies in which a substantial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84d63ec4abc1b9b6d3ac8a9f86fdc946
https://pubmed.ncbi.nlm.nih.gov/27006153
https://pubmed.ncbi.nlm.nih.gov/27006153
Publikováno v:
Cardiovascular therapeutics. 30(3)
Despite an extensive literature defining the mechanisms and significance of pathological myocardial remodeling, there has been no comprehensive review of the inverse process, often labeled reverse remodeling. Accordingly, the goal of this review is t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0dcc517cb9204a2eb7417b4b0f4b7ca1
https://pubmed.ncbi.nlm.nih.gov/21108773
https://pubmed.ncbi.nlm.nih.gov/21108773
Autor:
Matthew D. Hall, Noeris K. Salam, Jennifer L. Hellawell, Henry M. Fales, Caroline B. Kensler, Joseph A. Ludwig, Gergely SzakaÌcs, David E. Hibbs, Michael M. Gottesman
Publikováno v:
Journal of Medicinal Chemistry; May2009, Vol. 52 Issue 10, p3191-3204, 14p