Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jennifer L. Güler"'
Autor:
Shiwei Liu, Adam C. Huckaby, Audrey C. Brown, Christopher C. Moore, Ian Burbulis, Michael J. McConnell, Jennifer L. Güler
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-23 (2021)
Abstract Single-cell genomics is a rapidly advancing field; however, most techniques are designed for mammalian cells. We present a single-cell sequencing pipeline for an intracellular parasite, Plasmodium falciparum, with a small genome of extreme b
Externí odkaz:
https://doaj.org/article/c0aa8fdcd77e47e2b462acb1a3425c1d
Publikováno v:
mBio, Vol 14, Iss 3 (2023)
ABSTRACT Mounting evidence demonstrates that nutritional environment can alter pathogen drug sensitivity. While the rich media used for in vitro culture contains supraphysiological nutrient concentrations, pathogens encounter a relatively restrictive
Externí odkaz:
https://doaj.org/article/89801be502ff418daa6cd7929ded9d74
Autor:
Mukhethwa Munzhedzi, Elizabeth T. Rogawski McQuade, Jennifer L. Guler, Piper E. Shifflett, Sara Krivacsy, Rebecca Dillingham, Pascal O. Bessong
Publikováno v:
Malaria Journal, Vol 20, Iss 1, Pp 1-12 (2021)
Abstract Background Malaria remains a global health concern and is endemic in Limpopo, Mpumalanga and KwaZulu Natal Provinces of South Africa, which aims to eliminate malaria by 2025. Community engagement plays a significant role in improving the acc
Externí odkaz:
https://doaj.org/article/099f617a849247ebb190d5d6297a322b
Autor:
Kennedy Kassaza, Anna C. Long, Jennifer M. McDaniels, Mharlove Andre, Wasswa Fredrickson, Dan Nyehangane, Patrick Orikiriza, Darwin J. Operario, Joel Bazira, Juliet A. Mwanga-Amumpaire, Christopher C. Moore, Jennifer L. Guler, Yap Boum
Publikováno v:
Malaria Journal, Vol 20, Iss 1, Pp 1-10 (2021)
Abstract Background Chloroquine (CQ) resistance is conferred by mutations in the Plasmodium falciparum CQ resistance transporter (pfcrt). Following CQ withdrawal for anti-malarial treatment, studies across malaria-endemic countries have shown a range
Externí odkaz:
https://doaj.org/article/f152dc36a8e54087990ba77a54094ca6
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-9 (2019)
Abstract Background Malaria is a major global health problem, with the Plasmodium falciparum protozoan parasite causing the most severe form of the disease. Prevalence of drug-resistant P. falciparum highlights the need to understand the biology of r
Externí odkaz:
https://doaj.org/article/2c09b23d3a244d4ba6f0de936a232b8a
Autor:
Awtum M. Brashear, Adam C. Huckaby, Qi Fan, Luke J. Dillard, Yubing Hu, Yuling Li, Yan Zhao, Zenglei Wang, Yaming Cao, Jun Miao, Jennifer L. Guler, Liwang Cui
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Plasmodium vivax is increasingly the dominant species of malaria in the Greater Mekong Subregion (GMS), which is pursuing regional malaria elimination. P. vivax lineages in the GMS are poorly characterized. Currently, P. vivax reference genomes are s
Externí odkaz:
https://doaj.org/article/f2c74672230a4aae908f033b7bd10034
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-19 (2017)
Abstract Background Malaria remains a major public health burden and resistance has emerged to every antimalarial on the market, including the frontline drug, artemisinin. Our limited understanding of Plasmodium biology hinders the elucidation of res
Externí odkaz:
https://doaj.org/article/76001a16e6694930a8c5bcb122364f69
Autor:
Maureen A. Carey, Vincent Covelli, Audrey Brown, Gregory L. Medlock, Mareike Haaren, Jessica G. Cooper, Jason A. Papin, Jennifer L. Guler
Publikováno v:
mSphere, Vol 3, Iss 2 (2018)
ABSTRACT Metabolomics is increasingly popular for the study of pathogens. For the malaria parasite Plasmodium falciparum, both targeted and untargeted metabolomics have improved our understanding of pathogenesis, host-parasite interactions, and antim
Externí odkaz:
https://doaj.org/article/9e4f3c0e95484af38850c730c8cbdcf2