Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jennifer L. Friz"'
Autor:
Silvia Lapenna, Anna Barlow, Subba Reddy Palli, Laurence Dinan, Robert E. Hormann, Jennifer L. Friz
Publikováno v:
FEBS Journal. 275:5785-5809
A set of thirty-two natural and ten semisynthetic ecdysteroids was assayed in murine 3T3 cells across ten different ecdysteroid receptor (EcR) ligand-binding domains derived from nine arthropod species in an engineered gene switch format. Among the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb15b60e10f09223bf1bac8f2f1a0f13
https://doi.org/10.1111/j.1742-4658.2008.06687.x
https://doi.org/10.1111/j.1742-4658.2008.06687.x
Autor:
Colin M. Tice, Caitlin K. Cavanaugh, Robert Eugene Hormann, Jessica A. Saggers, Christine S. Thompson, Jennifer L. Friz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1883-1886
Fifteen new α-acylaminoketones were prepared by four different routes in an initial effort to optimize the potency of these compounds as ecdysone agonists. The compounds were assayed in mammalian cells expressing the ecdysone receptors from Bombyx m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300537d5b2dd2ce3607a92156f855ca2
https://doi.org/10.1016/s0960-894x(03)00315-9
https://doi.org/10.1016/s0960-894x(03)00315-9
Autor:
Jennifer L. Friz, Priya R. Baraniak, William R. Wagner, Cory E. Leeson, Jianjun Guan, Yi Hong, Anand K. Katakam, Dean E. Cress, Devin M. Nelson
Publikováno v:
Biomaterials. 32(11)
Gene expression can be controlled in genetically modified cells by employing an inducer/promoter system where presence of the inducer molecule regulates the timing and level of gene expression. By applying the principles of controlled release, it sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::207dd7f85d6cb2597d6f1f0bb076152b
https://pubmed.ncbi.nlm.nih.gov/21269687
https://pubmed.ncbi.nlm.nih.gov/21269687
Autor:
Jianzhong Liu, Silvia Lapenna, Anton J. Hopfinger, Laurence Dinan, Jennifer L. Friz, Robert E. Hormann
Publikováno v:
ChemMedChem. 4(1)
The ligand-inducible, ecdysteroid receptor (EcR) gene-expression system can add critical control features to protein expression in cell and gene therapy. However, potent natural ecdysteroids possess absorption, distribution, metabolism and excretion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60eb4c6e29cb8289423ebd4b9cc1b843
https://pubmed.ncbi.nlm.nih.gov/19065574
https://pubmed.ncbi.nlm.nih.gov/19065574
Autor:
Howard Smith, Jennifer L. Friz, Christine S. Thompson, Colin M. Tice, Jessica A. Saggers, Javier Garcia, Enrique Luis Michelotti, Caitlin K. Cavanaugh
Publikováno v:
ChemInform. 34
A library of 35 cis-1-benzoyl-2-methyl-4-(phenylamino)-1,2,3,4-tetrahydroquinolines was prepared. The compounds bore various substitutuents on the benzoyl ring, at the 4-position of the phenylamino ring and at the 6-position of the tetrahydroquinolin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee7fc0864a8dcc4eb112dc197da017c
https://doi.org/10.1002/chin.200335116
https://doi.org/10.1002/chin.200335116
Autor:
Christine S. Thompson, Javier Garcia, Fernando Albericio, Enrique Luis Michelotti, Ernesto Nicolás, Robert Eugene Hormann, Caitlin K. Cavanaugh, Colin M. Tice, Jennifer L. Friz
Publikováno v:
ChemInform. 34
A lead discovery library and a follow-up focused library of α-acylaminoketones were designed based on known dibenzoylhydrazine ecdysone agonists, including GS ™ –E. The compounds were assayed in mammalian cells expressing the ecdysone receptor f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc79cfc407711a605af23d9e70b2129
https://doi.org/10.1002/chin.200320102
https://doi.org/10.1002/chin.200320102
Publikováno v:
Molecular Therapy. 11:S410
The RheoSwitch|[trade]| two-hybrid gene regulation system is the most tightly regulated system available for induction of a transgene, which may be critical for some gene therapy applications. This ecdysone receptor (EcR)-based system uses non-steroi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2950e6d98301d6a181ce4db695b8088e
https://doi.org/10.1016/j.ymthe.2005.07.610
https://doi.org/10.1016/j.ymthe.2005.07.610
Autor:
Jennifer L. Friz, Andy Meyer, Subba Reddy Palli, Orestes Chortyk, Christine S. Thompson, Dean Ervin Cress, Mohan Kuman, Robert E. Hormann, Tom Meteyer, Beth Vertin, Howard Smith
Publikováno v:
Molecular Therapy. 9:S382
Drug-inducible regulation of multiple genes independently and simultaneously is a highly desirable gene therapy capability. Actuation of a plurality of genes with members of a common chemotype, rather than several unrelated chemotypes, could provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50cfeae33c02088cf783f6f7982e3c26
https://doi.org/10.1016/j.ymthe.2004.06.937
https://doi.org/10.1016/j.ymthe.2004.06.937