Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Jennifer L. Fisher"'
Autor:
Jennifer L. Fisher, Elizabeth J. Wilk, Vishal H. Oza, Sam E. Gary, Timothy C. Howton, Victoria L. Flanary, Amanda D. Clark, Anita B. Hjelmeland, Brittany N. Lasseigne
Publikováno v:
FEBS Open Bio, Vol 14, Iss 5, Pp 803-830 (2024)
Drug repurposing is promising because approving a drug for a new indication requires fewer resources than approving a new drug. Signature reversion detects drug perturbations most inversely related to the disease‐associated gene signature to identi
Externí odkaz:
https://doaj.org/article/f40949cccc344b50a5660d71408edfbd
Autor:
John A. Barth, Stephen D. Pierce, Brendan R. Carter, Francis Chan, Anatoli Y. Erofeev, Jennifer L. Fisher, Richard A. Feely, Kym C. Jacobson, Aimee A. Keller, Cheryl A. Morgan, John E. Pohl, Leif K. Rasmuson, Victor Simon
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The 2021 summer upwelling season off the United States Pacific Northwest coast was unusually strong leading to widespread near-bottom, low-oxygen waters. During summer 2021, an unprecedented number of ship- and underwater glider-based measur
Externí odkaz:
https://doaj.org/article/b6925240e9814506b3565ce0e00b303f
Autor:
Andrew R. Thompson, Rasmus Swalethorp, Michaela Alksne, Jarrod A. Santora, Elliott L. Hazen, Andrew Leising, Erin Satterthwaite, William J. Sydeman, Clarissa R. Anderson, Toby D. Auth, Simone Baumann-Pickering, Timothy Baumgardner, Eric P. Bjorkstedt, Steven J. Bograd, Noelle M. Bowlin, Brian J. Burke, Elizabeth A. Daly, Heidi Dewar, John C. Field, Jennifer L. Fisher, Newell Garfield, Ashlyn Gidding, Ralf Goericke, Richard Golightly, Eliana Gómez-Ocampo, Jose Gomez-Valdes, John A. Hildebrand, Kym C. Jacobson, Michael G. Jacox, Jaime Jahncke, Michael Johns, Joshua M. Jones, Bertha Lavaniegos, Nate Mantua, Gerard J. McChesney, Megan E. Medina, Sharon R. Melin, Luis Erasmo Miranda, Cheryl A. Morgan, Catherine F. Nickels, Rachael A. Orben, Jessica M. Porquez, Antonella Preti, Roxanne R. Robertson, Daniel L. Rudnick, Keith M. Sakuma, Carley R. Schacter, Isaac D. Schroeder, Lauren Scopel, Owyn E. Snodgrass, Sarah Ann Thompson, Pete Warzybok, Katherine Whitaker, William Watson, Edward D. Weber, Brian Wells
Publikováno v:
Frontiers in Marine Science, Vol 11 (2024)
2022 marked the third consecutive La Niña and extended the longest consecutive stretch of negative Oceanic Niño Index since 1998-2001. While physical and biological conditions in winter and spring largely adhered to prior La Niña conditions, summe
Externí odkaz:
https://doaj.org/article/f71e0400449d471a8acf0e6cdc8909a8
Publikováno v:
Cancer Reports, Vol 6, Iss 12, Pp n/a-n/a (2023)
Abstract Background Cancer is a complex disease that is the second leading cause of death in the United States. Despite research efforts, the ability to manage cancer and select optimal therapeutic responses for each patient remains elusive. Chromoso
Externí odkaz:
https://doaj.org/article/fc55d8f10ddf4e04996a60fab76d1f83
Autor:
Elizabeth J. Wilk, Timothy C. Howton, Jennifer L. Fisher, Vishal H. Oza, Ryan T. Brownlee, Kasi C. McPherson, Hannah L. Cleary, Bradley K. Yoder, James F. George, Michal Mrug, Brittany N. Lasseigne
Publikováno v:
Molecular Medicine, Vol 29, Iss 1, Pp 1-21 (2023)
Abstract Background Autosomal dominant polycystic kidney disease (ADPKD) is one of the most prevalent monogenic human diseases. It is mostly caused by pathogenic variants in PKD1 or PKD2 genes that encode interacting transmembrane proteins polycystin
Externí odkaz:
https://doaj.org/article/a29d831d0f624c96a1f2239ed4a5233e
Publikováno v:
Cancer Reports, Vol 6, Iss 9, Pp n/a-n/a (2023)
Abstract Background Preclinical models like cancer cell lines and patient‐derived xenografts (PDXs) are vital for studying disease mechanisms and evaluating treatment options. It is essential that they accurately recapitulate the disease state of i
Externí odkaz:
https://doaj.org/article/d7dab3e4abaa48a795470fdab801ed58
Publikováno v:
PeerJ, Vol 11, p e15244 (2023)
Genomic instability is an important hallmark of cancer and more recently has been identified in others like neurodegenrative diseases. Chromosomal instability, as a measure of genomic instability, has been used to characterize clinical and biological
Externí odkaz:
https://doaj.org/article/2b7bda82b19e4b839625dc19ae09106b
Planktonic foraminiferal assemblages reflect warming during two recent mid-latitude marine heatwaves
Autor:
M. Kelsey Lane, Jennifer S. Fehrenbacher, Jennifer L. Fisher, Melanie R. Fewings, Byron C. Crump, Craig M. Risien, Grace M. L. Meyer, Faith Schell
Publikováno v:
Frontiers in Marine Science, Vol 10 (2023)
Under future climate scenarios, ocean temperatures that are presently extreme and qualify as marine heatwaves (MHW) are forecasted to increase in frequency and intensity, but little is known about the impact of these events on one of the most common
Externí odkaz:
https://doaj.org/article/503b5070c8da4543823b632c0b7604f5
Autor:
Jennifer L. Fisher, Emma F. Jones, Victoria L. Flanary, Avery S. Williams, Elizabeth J. Ramsey, Brittany N. Lasseigne
Publikováno v:
Biology of Sex Differences, Vol 13, Iss 1, Pp 1-23 (2022)
Highlights Genetic, epigenetic, hormonal, immunological, metabolic, and environmental factors affect sex-biased drug responses. Drug repurposing approaches provide a significant advantage over novel drug development by reducing lengthy and costly cli
Externí odkaz:
https://doaj.org/article/a8821dfe23fd4b169cfc582a6557e6e3
Autor:
Andrew R. Thompson, Eric P. Bjorkstedt, Steven J. Bograd, Jennifer L. Fisher, Elliott L. Hazen, Andrew Leising, Jarrod A. Santora, Erin V. Satterthwaite, William J. Sydeman, Michaela Alksne, Toby D. Auth, Simone Baumann-Pickering, Noelle M. Bowlin, Brian J. Burke, Elizabeth A. Daly, Heidi Dewar, John C. Field, Newell T. Garfield, Ashlyn Giddings, Ralf Goericke, John Hildebrand, Cheryl A. Horton, Kym C. Jacobson, Michael G. Jacox, Jaime Jahncke, Michael Johns, Joshua Jones, Raphe M. Kudela, Sharon R. Melin, Cheryl A. Morgan, Catherine F. Nickels, Rachael A. Orben, Jessica M. Porquez, Elan J. Portner, Antonella Preti, Roxanne R. Robertson, Daniel L. Rudnick, Keith M. Sakuma, Isaac D. Schroeder, Owyn E. Snodgrass, Sarah Ann Thompson, Jennifer S. Trickey, Pete Warzybok, William Watson, Edward D. Weber
Publikováno v:
Frontiers in Marine Science, Vol 9 (2022)
In late 2020, models predicted that a strong La Niña would take place for the first time since 2013, and we assessed whether physical and biological indicators in 2021 were similar to past La Niñas in the California Current Ecosystem (CCE). The Pac
Externí odkaz:
https://doaj.org/article/2453c1e2ca6f4478b963f513d09858f2