Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jennifer L. Auger"'
Autor:
Daniel P. Zachs, Sarah J. Offutt, Rachel S. Graham, Yohan Kim, Jerel Mueller, Jennifer L. Auger, Nathaniel J. Schuldt, Claire R. W. Kaiser, Abigail P. Heiller, Raini Dutta, Hongsun Guo, Jamu K. Alford, Bryce A. Binstadt, Hubert H. Lim
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Modulation of the cholinergic pathway and spleen function can reduce inflammation with invasive implants. Here, the authors show that non-invasive ultrasound stimulation of the spleen reduces disease severity in a mouse model of inflammatory arthriti
Externí odkaz:
https://doaj.org/article/85dd15ea79c645d8ba32290636c10411
Autor:
Raini Dutta, Mary M. Lunzer, Jennifer L. Auger, Eyup Akgün, Philip S. Portoghese, Bryce A. Binstadt
Publikováno v:
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-10 (2018)
Abstract Background Pain accompanies rheumatoid arthritis and other chronic inflammatory conditions and is difficult to manage. Although opioids provide potent analgesia, chronic opioid use can cause tolerance and addiction. Recent studies have demon
Externí odkaz:
https://doaj.org/article/52d8dea972c8455d9122c10989aa592a
Autor:
Ben F. Brian, Monica L. Sauer, Joseph T. Greene, S. Erandika Senevirathne, Anders J. Lindstedt, Olivia L. Funk, Brian L. Ruis, Luis A. Ramirez, Jennifer L. Auger, Whitney L. Swanson, Myra G. Nunez, Branden S. Moriarity, Clifford A. Lowell, Bryce A. Binstadt, Tanya S. Freedman
Publikováno v:
Science advances, vol 8, iss 16
Here, we report that the LynB splice variant of the Src-family kinase Lyn exerts a dominant immunosuppressive function in vivo, whereas the LynA isoform is uniquely required to restrain autoimmunity in female mice. We used CRISPR-Cas9 gene editing to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79a31ea6ce138ddaa264f5f1d06771d
https://escholarship.org/uc/item/4pr231mw
https://escholarship.org/uc/item/4pr231mw
Autor:
Bryce A. Binstadt, Nathaniel J. Schuldt, Claire R. W. Kaiser, Abigail P. Heiller, Jamu K. Alford, Raini Dutta, Hongsun Guo, Daniel P. Zachs, Jennifer L. Auger, Sarah J. Offutt, Jerel K. Mueller, Yohan Kim, Rachel S. Graham, Hubert H. Lim
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications
Nature Communications
Targeted noninvasive control of the nervous system and end-organs may enable safer and more effective treatment of multiple diseases compared to invasive devices or systemic medications. One target is the cholinergic anti-inflammatory pathway that co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dd7fe97d2d08acb269cc89221346c3d
http://link.springer.com/article/10.1038/s41467-019-08721-0
http://link.springer.com/article/10.1038/s41467-019-08721-0
Autor:
Margreet Kloppenburg, Mauro Perretti, René E. M. Toes, Bryce A. Binstadt, Mayra Gonzalez-Torres, Tom W J Huizinga, Cristina López-Vicario, Hilde Brouwers, Jennifer L. Auger, Jose Garrido-Mesa, Joan Clària, M. Giera, Hulda S Jónasdóttir, J.C. Kwekkeboom, Jona Freysdottir, Ingibjorg Hardardottir, Andreea Ioan-Facsinay, Marije E. Kuipers, Lucy V. Norling
Publikováno v:
Journal of Immunology, 205(10), 2840-2849. AMER ASSOC IMMUNOLOGISTS
Polyunsaturated fatty acids (PUFAs) and their metabolites are potent regulators of inflammation. Generally, omega (n)-3 PUFAs are considered proresolving whereas n-6 PUFAs are classified as proinflammatory. In this study, we characterized the inflamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::965b1ca862943353cbc2c7e256bd6946
https://doi.org/10.4049/jimmunol.1801653
https://doi.org/10.4049/jimmunol.1801653
Autor:
Immo Prinz, Bryce A. Binstadt, Jennifer L. Auger, Sakeen W. Kashem, Hannah M. Cowan, Brianna J. Engelson
Publikováno v:
Arthritis & Rheumatology. 68:1849-1855
Objective Th17 cells and interleukin-17 (IL-17) cytokine family members are implicated in the pathogenesis of many rheumatic diseases. Most studies in mouse models of inflammatory arthritis have demonstrated a key role for the proinflammatory cytokin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42174108d82b1b373293ecf7eb85ec1a
https://doi.org/10.1002/art.39646
https://doi.org/10.1002/art.39646
Autor:
Philip S. Portoghese, Eyup Akgün, Bryce A. Binstadt, Mary M. Lunzer, Raini Dutta, Jennifer L. Auger
Publikováno v:
Arthritis Research & Therapy
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-10 (2018)
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-10 (2018)
Background Pain accompanies rheumatoid arthritis and other chronic inflammatory conditions and is difficult to manage. Although opioids provide potent analgesia, chronic opioid use can cause tolerance and addiction. Recent studies have demonstrated f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b70c20bc7a2895cfa8935de23d2244a5
https://pubmed.ncbi.nlm.nih.gov/30053832
https://pubmed.ncbi.nlm.nih.gov/30053832
Autor:
Gregory R. Schuneman, Patricia M. Hobday, Bryce A. Binstadt, Stefanie Haasken, Jennifer L. Auger, J. Sjef Verbeek
Publikováno v:
Arthritis & Rheumatology. 66:852-862
Objective Arthritis and valvular carditis coexist in several human rheumatic diseases, including systemic lupus erythematosus, rheumatic fever, and rheumatoid arthritis. T cell receptor–transgenic K/BxN mice develop spontaneous autoantibody-associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24d4f317726931eeca8fc19e794b35f0
https://doi.org/10.1002/art.38311
https://doi.org/10.1002/art.38311
Autor:
Jennifer L. Auger, Brian D. Goudy, Bryce A. Binstadt, Daniel L. Mueller, Stefanie Haasken, Justin J. Taylor, Philip J. Titcombe, Patricia M. Hobday
Publikováno v:
The Journal of Immunology. 191:1055-1062
The class A macrophage scavenger receptor Msr1 (SR-A, CD204) has been reported to participate in the maintenance of immunological tolerance. We investigated the role of Msr1 in a mouse model of autoantibody-dependent arthritis. Genetic deficiency of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de15bf03cc440bc455ec5c453733a271
https://doi.org/10.4049/jimmunol.1201680
https://doi.org/10.4049/jimmunol.1201680
Publikováno v:
European Journal of Immunology. 42:2354-2362
Allelic exclusion of antigen receptor loci is a fundamental mechanism of immunological self-tolerance. Incomplete allelic exclusion leads to dual T-cell receptor (TCR) expression and can allow developing autoreactive αβ T lymphocytes to escape clon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::069c694bca5971bc87ca945b6f41201c
https://doi.org/10.1002/eji.201242520
https://doi.org/10.1002/eji.201242520