Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jennifer L. Auer"'
Autor:
George Procopiou, Paul J. M. Jackson, Daniella di Mascio, Jennifer L. Auer, Chris Pepper, Khondaker Miraz Rahman, Keith R. Fox, David E. Thurston
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
A class of Cyclopropabenzindole-Pyridinobenzodiazepine (CBI-PDD) DNA cross-linking payloads, used in Antibody-Drug Conjugates, alkylate guanine and adenine bases in the DNA minor groove with a defined sequence selectivity.
Externí odkaz:
https://doaj.org/article/5745b8e61aa3408ca18a41c49e313d1d
Autor:
Stephen Patterson, Susan Wyllie, Suzanne Norval, Laste Stojanovski, Frederick RC Simeons, Jennifer L Auer, Maria Osuna-Cabello, Kevin D Read, Alan H Fairlamb
Publikováno v:
eLife, Vol 5 (2016)
There is an urgent requirement for safe, oral and cost-effective drugs for the treatment of visceral leishmaniasis (VL). We report that delamanid (OPC-67683), an approved drug for multi-drug resistant tuberculosis, is a potent inhibitor of Leishmania
Externí odkaz:
https://doaj.org/article/830d1f9ce1e54963993ed6b35157f836
Autor:
Shirin Jamshidi, Hollie V. Taylor, Charlotte K. Hind, Khondaker M. Rahman, Jennifer L. Auer, Lucy J. Bock, Matthew E. Wand, J. Mark Sutton
Publikováno v:
International Journal of Antimicrobial Agents. 54:538-546
To understand the potential utility of novel nitroreductase (NR)-activated prodrugs, NR enzyme activity was assessed in clinical Klebsiella pneumoniae isolates using a NR-activated fluorescent probe. NR activity was constant throughout the bacterial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a263b3345455069889f5414e1143413
https://doi.org/10.1016/j.ijantimicag.2019.08.009
https://doi.org/10.1016/j.ijantimicag.2019.08.009
Autor:
George Procopiou, Paul J. Jackson, Daniella M. di Mascio, Jennifer L. Auer, Paolo Andriollo, Ilona Pysz, Khondaker M. Rahman, Keith R. Fox, David E. Thurston
Publikováno v:
Cancer Research. 82:1749-1749
Antibody-Drug Conjugates (ADCs) are rapidly growing in importance as a targeted cancer therapy, with over ten approved, and many currently undergoing clinical trials. ADCs comprise of a cytotoxic agent (i.e., the "payload") conjugated via a chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6014263694d37cfeeb757f17d3b66701
https://doi.org/10.1158/1538-7445.am2022-1749
https://doi.org/10.1158/1538-7445.am2022-1749
Autor:
Alan H. Fairlamb, Susan Wyllie, Suzanne Norval, Frederick R. C. Simeons, Laste Stojanovski, Kevin D. Read, Stephen Patterson, Maria Osuna-Cabello, Jennifer L. Auer
Publikováno v:
eLife, Vol 5 (2016)
eLife
eLife
There is an urgent requirement for safe, oral and cost-effective drugs for the treatment of visceral leishmaniasis (VL). We report that delamanid (OPC-67683), an approved drug for multi-drug resistant tuberculosis, is a potent inhibitor of Leishmania
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113baf7feda7f97411e6ec1f1e4f6071
https://elifesciences.org/articles/09744
https://elifesciences.org/articles/09744
Autor:
Alan H. Fairlamb, Susan Wyllie, Kevin D. Read, Frederick R. C. Simeons, Suzanne Norval, Laste Stojanovski, Stephen Patterson, Maria Osuna-Cabello, Jennifer L. Auer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68f8b04ade7aa8c570e75041716c4e1f
https://doi.org/10.7554/elife.09744.018
https://doi.org/10.7554/elife.09744.018
