Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jennifer L. Ariazi"'
Autor:
Jennifer L. Ariazi, Hemant Joshi, Bethi Sridhar Reddy, Mui Cheung, Tangirala Raghuram, Sanjay Kumar, Vijaya G. Tirunagaru
Publikováno v:
ACS Medicinal Chemistry Letters. 9:103-108
Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) plays an important role in triglyceride synthesis and is a target of interest for the treatment of metabolic disorders. Herein we describe the structure–activity relationship of a novel tetralone se
Autor:
Mui Cheung, Jennifer L. Ariazi, Shristy Tiwari, Sayan Mitra, Douglas W. Thomson, Giovanna Bergamini, Sanjay Kumar, Premkumar Arumugam, Vijaya G. Tirunagaru, Amit Awasthi, Venkatesh Babu Jayaraman, Mahesh Yanamandra, Tangirala Raghuram, Thilo Werner
Publikováno v:
Journal of Pharmaceutical Research International. 18:1-15
Background and Aim: Acyl-CoA: diacylglycerol acyltransferase 1 (DGAT1) is a key enzyme catalyzing the final step of triglyceride (TG) synthesis and is implicated in fat absorption and disposition. However, development of several DGAT1 inhibitors has
Autor:
Connie L. Erickson-Miller, Erin Hugger DiFilippo, Ken Wiggall, Tony Shaw, Melissa B. Pappalardi, Mangatt P. Biju, David F. Adams, Jennifer L. Ariazi, Kevin J. Duffy, Duke M. Fitch, Lusong Luo
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 363(3)
Decreased erythropoietin (EPO) production, shortened erythrocyte survival, and other factors reducing the response to EPO contribute to anemia in patients who have a variety of underlying pathologies such as chronic kidney disease. Treatment with rec
Autor:
Beat M. Jucker, Connie L. Erickson-Miller, Weike Bao, Saul Needle, G. C. Teg Pipes, Jennifer L. Ariazi, Robert N. Willette, Alan R. Olzinski, Erding Hu, John J. Lepore, David J. Behm, Shufang Zhao, Kevin J. Duffy, Pu Qin
Publikováno v:
Journal of Cardiovascular Pharmacology. 56:147-155
Hypoxia inducible factors (HIFs) are transcription factors that are regulated by HIF-prolyl 4-hydroxylases (PHDs) in response to changes in oxygen tension. Once activated, HIFs play an important role in angiogenesis, erythropoiesis, proliferation, ce
Publikováno v:
Nuclear Receptors as Drug Targets
The estrogen receptor alpha (ERalpha) has proven to be the single most important target in breast cancer over the last 30 years. The use of the selective ER modulator (SERM) tamoxifen for the treatment and prevention of breast cancer has changed ther
Autor:
Jennifer L. Ariazi, Joan S. Lewis-Wambi, V. Craig Jordan, Tianyu Li, Fernando Cordera, Helen Kim, Shaun D. Gill, Heather A. Shupp, Jennifer R. Pyle, Catherine G.N. Sharma, Eric A. Ariazi
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 102:128-138
We seek to evaluate the clinical consequences of resistance to antihormonal therapy by studying analogous animal xenograft models. Two approaches were taken: (1) MCF-7 tumors were serially transplanted into selective estrogen receptor modulator (SERM
Publikováno v:
Molecular Carcinogenesis. 43:155-164
Knowing that the prepubertal period is a time of enhanced susceptibility for radiation-induced human breast cancer, we used the Fischer 344 rat model to explore the age-differential susceptibility of the mammary gland to the carcinogenic, lethal, and
Publikováno v:
Molecular Carcinogenesis. 44:193-201
The prepubertal breast is more susceptible than the mature breast to the carcinogenic effects of ionizing radiation, and potentially to cigarette smoke and alkylating chemotherapeutics. Mammary epithelial cells (MECs) from sexually immature (3-week (
Autor:
Hong Lin, Charles B. Davis, Kaushik Raha, Ralph A. Rivero, Michael D. Schaber, Jeanelle McSurdy-Freed, Mary Ann Hardwicke, Karl F. Erhard, James F. Mack, Ren Xie, Michael D. Spengler, Ramona Plant, Cynthia M. Rominger, Junya Qu, Rosanna Tedesco, Jennifer L. Ariazi, Juan I. Luengo, Mark J. Schulz, Michael D. Squire, Christian S. Sherk, Jin Zeng
A novel thiazolopyrimidinone series of PI3K-beta selective inhibitors has been identified. This chemotype has provided an excellent tool compound, 18, that showed potent growth inhibition in the PTEN-deficient breast cancer cell line MDA-MB-468 under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ace88350b0677b6d5e549d1aab456577
https://europepmc.org/articles/PMC4025772/
https://europepmc.org/articles/PMC4025772/
Publikováno v:
Current topics in medicinal chemistry. 6(3)
The estrogen receptor alpha (ERalpha) has proven to be the single most important target in breast cancer over the last 30 years. The use of the selective ER modulator (SERM) tamoxifen for the treatment and prevention of breast cancer has changed ther