Zobrazeno 1 - 10 of 96 pro vyhledávání: '"Jennifer L Whistler"'
1
Akademický článek
Anti-analgesic effect of the mu/delta opioid receptor heteromer revealed by ligand-biased antagonism.
Autor: Laura Milan-Lobo, Johan Enquist, Richard M van Rijn, Jennifer L Whistler
Publikováno v: PLoS ONE, Vol 8, Iss 3, p e58362 (2013)
Delta (DOR) and mu opioid receptors (MOR) can complex as heteromers, conferring functional properties in agonist binding, signaling and trafficking that can differ markedly from their homomeric counterparts. Because of these differences, DOR/MOR hete
Externí odkaz: https://doaj.org/article/1ab2de99860e4231a31ed40e8c2178f4
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2
Akademický článek
PGH1, the precursor for the anti-inflammatory prostaglandins of the 1-series, is a potent activator of the pro-inflammatory receptor CRTH2/DP2.
Autor: Ralf Schröder, Luzheng Xue, Viktoria Konya, Lene Martini, Nora Kampitsch, Jennifer L Whistler, Trond Ulven, Akos Heinemann, Roy Pettipher, Evi Kostenis
Publikováno v: PLoS ONE, Vol 7, Iss 3, p e33329 (2012)
Prostaglandin H(1) (PGH(1)) is the cyclo-oxygenase metabolite of dihomo-γ-linolenic acid (DGLA) and the precursor for the 1-series of prostaglandins which are often viewed as "anti-inflammatory". Herein we present evidence that PGH(1) is a potent ac
Externí odkaz: https://doaj.org/article/a776db4b8f144f759e59d2a198adaf12
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3
Akademický článek
Chronic ethanol consumption in rats produces opioid antinociceptive tolerance through inhibition of mu opioid receptor endocytosis.
Autor: Li He, Jennifer L Whistler
Publikováno v: PLoS ONE, Vol 6, Iss 5, p e19372 (2011)
It is well known that the mu-opioid receptor (MOR) plays an important role in the rewarding properties of ethanol. However, it is less clear how chronic ethanol consumption affects MOR signaling. Here, we demonstrate that rats with prolonged voluntar
Externí odkaz: https://doaj.org/article/3a753815db3a431e906f71647d2eec7f
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4
Akademický článek
Altered ratio of D1 and D2 dopamine receptors in mouse striatum is associated with behavioral sensitization to cocaine.
Autor: Dawn Thompson, Lene Martini, Jennifer L Whistler
Publikováno v: PLoS ONE, Vol 5, Iss 6, p e11038 (2010)
Drugs of abuse elevate brain dopamine levels, and, in vivo, chronic drug use is accompanied by a selective decrease in dopamine D2 receptor (D2R) availability in the brain. Such a decrease consequently alters the ratio of D1R:D2R signaling towards th
Externí odkaz: https://doaj.org/article/701d98e1c53b4bf99cf6bd0aed02403b
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5
Akademický článek
TGF-β Signaling in Dopaminergic Neurons Regulates Dendritic Growth, Excitatory-Inhibitory Synaptic Balance, and Reversal Learning
Autor: Sarah X. Luo, Leah Timbang, Jae-Ick Kim, Yulei Shang, Kadellyn Sandoval, Amy A. Tang, Jennifer L. Whistler, Jun B. Ding, Eric J. Huang
Publikováno v: Cell Reports, Vol 17, Iss 12, Pp 3233-3245 (2016)
Neural circuits involving midbrain dopaminergic (DA) neurons regulate reward and goal-directed behaviors. Although local GABAergic input is known to modulate DA circuits, the mechanism that controls excitatory/inhibitory synaptic balance in DA neuron
Externí odkaz: https://doaj.org/article/06ca2f6c0cdc48f4a2063de3cbdee880
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6
Deletion of arrestin-3 does not alter compulsive morphine-seeking behavior in an oral operant self-administration paradigm
Autor: Lindsey Felth, Sarah Gooding, Randi Foxhall, Zachary Rosa, Kyle Ireton, Izabella Sall, Joshua Gipoor, Anirudh Gaur, Madeline King, Noah Dirks, Cheryl A. Whistler, Jennifer L. Whistler
Opioid drugs are potent analgesics that mimic the endogenous opioid peptides, endorphins and enkephalins, by activating the µ-opioid receptor. Opioid use is limited by side effects, including significant risk of opioid use disorder. Improvement of t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::147aa5c4b20c5ebfbdb100a7b5b9d480
https://doi.org/10.1101/2023.03.30.534994
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8
Arrestin-3 agonism at D3 dopamine receptors defines a subclass of second generation antipsychotics that promotes drug tolerance
Autor: Selin Schamiloglu, Elinor Lewis, Anne C. Hergarden, Kevin J. Bender, Jennifer L. Whistler
Second generation antipsychotics (SGAs) are front-line treatments for serious mental illness. Often, individual patients benefit only from some SGAs and not others. The mechanisms underlying this unpredictability in treatment efficacy remain unclear.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::92a8fc3996780dc94ef87c4e91e2f665
https://doi.org/10.1101/2022.08.17.504324
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9
Pharmacological and genetic manipulations at the µ-opioid receptor reveal arrestin-3 engagement limits analgesic tolerance and does not exacerbate respiratory depression in mice
Autor: Elinor L. Lewis, Li He, Jennifer L. Whistler, Anirudh Gaur, Lindsey C. Felth, Sarah W. Gooding
Publikováno v: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, vol 46, iss 13
Neuropsychopharmacology
Neuropsychopharmacology, vol 46, iss 13
Opioid drugs are widely used analgesics that activate the G protein-coupled µ-opioid receptor, whose endogenous neuropeptide agonists, endorphins and enkephalins, are potent pain relievers. The therapeutic utility of opioid drugs is hindered by deve
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aaf4a3e0c0048b346279e65d19c9529
https://escholarship.org/uc/item/3863b0tb
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