Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jennifer L Rowsey"'
Autor:
Dominik Saul, David G Monroe, Jennifer L Rowsey, Robyn Laura Kosinsky, Stephanie J Vos, Madison L Doolittle, Joshua N Farr, Sundeep Khosla
Publikováno v:
eLife, Vol 10 (2021)
Senescent cells have detrimental effects across tissues with aging but may have beneficial effects on tissue repair, specifically on skin wound healing. However, the potential role of senescent cells in fracture healing has not been defined. Here, we
Externí odkaz:
https://doaj.org/article/8ba3a1c1e49d4f94bed1c548b3fd0494
Autor:
Madison L. Doolittle, Dominik Saul, Japneet Kaur, Jennifer L. Rowsey, Stephanie J. Vos, Kevin D. Pavelko, Joshua N. Farr, David G. Monroe, Sundeep Khosla
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Senescence drives organismal aging, yet the deep characterization of senescent cells in vivo remains incomplete. Here, we apply mass cytometry by time-of-flight using carefully validated antibodies to analyze senescent cells at single-cell r
Externí odkaz:
https://doaj.org/article/9fa996d1eacd483380e6493e7833f68e
Autor:
Madison L. Doolittle, Brittany A. Eckhardt, Stephanie J. Vos, Sarah Grain, Jennifer L. Rowsey, Ming Ruan, Dominik Saul, Joshua N. Farr, Megan M. Weivoda, Sundeep Khosla, David G. Monroe
Publikováno v:
JBMR Plus, Vol 7, Iss 10, Pp n/a-n/a (2023)
ABSTRACT Estrogen regulates bone mass in women and men, but the underlying cellular mechanisms of estrogen action on bone remain unclear. Although both estrogen receptor (ER)α and ERβ are expressed in bone cells, ERα is the dominant receptor for s
Externí odkaz:
https://doaj.org/article/fce9a970aa3344afb432ff2b7082076c
Autor:
Joshua N. Farr, Dominik Saul, Madison L. Doolittle, Japneet Kaur, Jennifer L. Rowsey, Stephanie J. Vos, Mitchell N. Froemming, Anthony B. Lagnado, Yi Zhu, Megan Weivoda, Yuji Ikeno, Robert J. Pignolo, Laura J. Niedernhofer, Paul D. Robbins, Diana Jurk, João F. Passos, Nathan K. LeBrasseur, Tamara Tchkonia, James L. Kirkland, David G. Monroe, Sundeep Khosla
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 8 (2023)
Clearance of senescent cells (SnCs) can prevent several age-related pathologies, including bone loss. However, the local versus systemic roles of SnCs in mediating tissue dysfunction remain unclear. Thus, we developed a mouse model (p16-LOX-ATTAC) th
Externí odkaz:
https://doaj.org/article/fc80a778d0594c49a7d28805675dc1fe
Autor:
Madison L. Doolittle, Dominik Saul, Japneet Kaur, Jennifer L. Rowsey, Stephanie J. Vos, Kevin D. Pavelko, Joshua N. Farr, David G. Monroe, Sundeep Khosla
Publikováno v:
bioRxiv
Senescence drives organismal aging, yet the deep characterization of senescent cellsin vivoremains incomplete. Here, we applied mass cytometry by time-of-flight (CyTOF) using carefully validated antibodies to analyze senescent cells at single-cell re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b8ab46e522df56d0c367751521f909
https://doi.org/10.1101/2023.01.12.523760
https://doi.org/10.1101/2023.01.12.523760
Autor:
Madison L. Doolittle, Dominik Saul, Japneet Kaur, Jennifer L. Rowsey, Brittany Eckhardt, Stephanie Vos, Sarah Grain, Kveta Kroupova, Ming Ruan, Megan Weivoda, Merry Jo Oursler, Joshua N. Farr, David G. Monroe, Sundeep Khosla
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 37(9)
Estrogen is known to regulate bone metabolism in both women and men, but substantial gaps remain in our knowledge of estrogen and estrogen receptor alpha (ERα) regulation of adult bone metabolism. Studies using global ERα-knockout mice were confoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3a1ca971724306a9305746f3ce92bc7
https://pubmed.ncbi.nlm.nih.gov/35789113
https://pubmed.ncbi.nlm.nih.gov/35789113
Autor:
Jennifer L. Rowsey, Joshua N. Farr, Daniel G. Fraser, Sundeep Khosla, Brittany A. Eckhardt, Ruben Aquino-Martinez, David G. Monroe
Publikováno v:
J Periodontol
Background Coinciding with other chronic comorbidities, the prevalence of periodontal disease increases with aging. Mounting evidence has established that senescent cells accumulate at sites of age-related pathologies, where they promote "non-microbi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69119a6ff110451bd46c5ceb6edea4ae
https://doi.org/10.1002/jper.20-0529
https://doi.org/10.1002/jper.20-0529
Autor:
Dominik Saul, Joshua N. Farr, David G. Monroe, Madison L. Doolittle, Sundeep Khosla, Stephanie J Vos, Robyn Laura Kosinsky, Jennifer L. Rowsey
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10ece03904019d33d235e1671b3561fa
https://doi.org/10.7554/elife.69958.sa2
https://doi.org/10.7554/elife.69958.sa2
Autor:
Brittany A. Eckhardt, Tamar Tchkonia, Jennifer L. Rowsey, Daniel G. Fraser, David G. Monroe, Joshua N. Farr, James L. Kirkland, Brianne S Thicke, Sundeep Khosla
Publikováno v:
J Bone Miner Res
Estrogen deficiency is a seminal mechanism in the pathogenesis of osteoporosis. Mounting evidence, however, establishes that cellular senescence, a fundamental mechanism that drives multiple age-related diseases, also causes osteoporosis. Recently, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af2652d7d3d33f8359d1d3fe99521780
https://doi.org/10.1002/jbmr.3729
https://doi.org/10.1002/jbmr.3729
Autor:
Japneet Kaur, Dominik Saul, Madison L. Doolittle, Jennifer L. Rowsey, Stephanie J. Vos, Joshua N. Farr, Sundeep Khosla, David G. Monroe
Publikováno v:
Gene. 835:146642
ObjectiveMicroRNAs (miRNAs) are promising tools as biomarkers and therapeutic agents in various chronic diseases such as osteoporosis, cancers, type I and II diabetes, and cardiovascular diseases. Considering the rising interest in the regulatory rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c414825953ce446a22675cec0df9206
https://doi.org/10.1016/j.gene.2022.146642
https://doi.org/10.1016/j.gene.2022.146642