Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Jennifer L Hope"'
Autor:
Manzhi Zhao, Caoimhe H Kiernan, Christopher J Stairiker, Jennifer L Hope, Leticia G Leon, Marjan van Meurs, Inge Brouwers-Haspels, Ruben Boers, Joachim Boers, Joost Gribnau, Wilfred F J van IJcken, Eric M Bindels, Remco M Hoogenboezem, Stefan J Erkeland, Yvonne M Mueller, Peter D Katsikis
Publikováno v:
PLoS Pathogens, Vol 16, Iss 6, p e1008555 (2020)
Exhaustion is a dysfunctional state of cytotoxic CD8+ T cells (CTL) observed in chronic infection and cancer. Current in vivo models of CTL exhaustion using chronic viral infections or cancer yield very few exhausted CTL, limiting the analysis that c
Externí odkaz:
https://doaj.org/article/0638732910034e3dbdc1bc9fe44b7d9d
Autor:
Joseph A Fraietta, Yvonne M Mueller, Guibin Yang, Alina C Boesteanu, Donald T Gracias, Duc H Do, Jennifer L Hope, Noshin Kathuria, Shannon E McGettigan, Mark G Lewis, Luis D Giavedoni, Jeffrey M Jacobson, Peter D Katsikis
Publikováno v:
PLoS Pathogens, Vol 9, Iss 10, p e1003658 (2013)
The role of Type I interferon (IFN) during pathogenic HIV and SIV infections remains unclear, with conflicting observations suggesting protective versus immunopathological effects. We therefore examined the effect of IFNα/β on T cell death and vire
Externí odkaz:
https://doaj.org/article/f681ebe2086b4e1387218826ddfdc7cf
Autor:
Jennifer L. Hope, Dennis C. Otero, Eun-Ah Bae, Christopher J. Stairiker, Ashley B. Palete, Hannah A. Faso, Michelle Lin, Monique L. Henriquez, Sreeja Roy, Hyungseok Seo, Xue Lei, Eric S. Wang, Savio Chow, Roberto Tinoco, Gregory A. Daniels, Kevin Yip, Alexandre Rosa Campos, Jun Yin, Peter D. Adams, Anjana Rao, Linda M. Bradley
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112436- (2023)
Summary: PSGL-1 (P-selectin glycoprotein-1) is a T cell-intrinsic checkpoint regulator of exhaustion with an unknown mechanism of action. Here, we show that PSGL-1 acts upstream of PD-1 and requires co-ligation with the T cell receptor (TCR) to atten
Externí odkaz:
https://doaj.org/article/067e0e4ee8fd4b5a973b514304627b4f
Autor:
Carol M. Artlett, Sihem Sassi-Gaha, Jennifer L. Hope, Carol A. Feghali-Bostwick, Peter D. Katsikis
Publikováno v:
Arthritis Research & Therapy, Vol 19, Iss 1, Pp 1-8 (2017)
Abstract Background Despite the important role that microRNAs (miRNAs) play in immunity and inflammation, their involvement in systemic sclerosis (SSc) remains poorly characterized. miRNA-155 (miR-155) plays a role in pulmonary fibrosis and its expre
Externí odkaz:
https://doaj.org/article/a8c9561d26774d778d9b845e5945974b
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Effective adaptive immune responses are characterized by stages of development and maturation of T and B cell populations that respond to disturbances in the host homeostasis in cases of both infections and cancer. For the T cell compartment, this be
Externí odkaz:
https://doaj.org/article/69cfb3667b96436ab3b9bffae796676b
Autor:
Jennifer L. Hope, Manzhi Zhao, Christopher J. Stairiker, Caoimhe H. Kiernan, Alison J. Carey, Yvonne M. Mueller, Marjan van Meurs, Inge Brouwers-Haspels, Dennis C. Otero, Eun-Ah Bae, Hannah A. Faso, Alex Maas, Hans de Looper, Paolo M. Fortina, Isidore Rigoutsos, Linda M. Bradley, Stefan J. Erkeland, Peter D. Katsikis
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950), 208(3), 603-617. American Association of Immunologists
MicroRNAs (miRNAs/miRs) are small, endogenous noncoding RNAs that are important post-transcriptional regulators with clear roles in the development of the immune system and immune responses. Using miRNA microarray profiling, we characterized the expr
Autor:
Alison J. Carey, Jennifer L. Hope, Yvonne M. Mueller, Adam J. Fike, Ogan K. Kumova, David B. H. van Zessen, Eric A. P. Steegers, Mirjam van der Burg, Peter D. Katsikis
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Respiratory support improvements have aided survival of premature neonates, but infection susceptibility remains a predominant problem. We previously reported that neonatal mice have a rapidly evolving T-cell receptor (TCR) repertoire that impairs CD
Externí odkaz:
https://doaj.org/article/33ca660065a440099528ad2eaf188cfc
Autor:
Jennifer L. Hope, Christopher J. Stairiker, Panagiota I. Spantidea, Donald T. Gracias, Alison J. Carey, Adam J. Fike, Marjan van Meurs, Inge Brouwers-Haspels, Laurine C. Rijsbergen, Joseph A. Fraietta, Yvonne M. Mueller, Rosemarieke C. Klop, Erietta Stelekati, E. John Wherry, Stefan J. Erkeland, Peter D. Katsikis
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
We report here that the expression of the transcription factor T-bet, which is known to be required for effector cytotoxic CD8+ T lymphocytes (CTL) generation and effector memory cell formation, is regulated in CTL by microRNA-155 (miR-155). Importan
Externí odkaz:
https://doaj.org/article/045e79ae899f4457b4050ae3c4bfc370
Autor:
Joseph S, Dolina, Joey, Lee, Eugene L, Moore, Jennifer L, Hope, Donald T, Gracias, Takaji, Matsutani, Ashu, Chawla, Jason A, Greenbaum, Joel, Linden, Stephen P, Schoenberger
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(10)
SignificanceThe CD4
Autor:
Joseph S. Dolina, Joey Lee, Eugene L. Moore, Jennifer L. Hope, Donald T. Gracias, Takaji Matsutani, Ashu Chawla, Jason A. Greenbaum, Joel Linden, Stephen P. Schoenberger
Publikováno v:
Proceedings of the National Academy of Sciences. 119
SignificanceThe CD4+Tregresponse following acuteListeriainfection is heterogeneous and deploys two distinct modes of suppression coinciding with initial pathogen exposure and resolution of infection. This bimodal suppression of CD8+T cells during pri