Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Jennifer L Guler"'
Autor:
Maureen A Carey, Gregory L Medlock, Michał Stolarczyk, William A Petri, Jennifer L Guler, Jason A Papin
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 2, p e1009870 (2022)
Protozoan parasites cause diverse diseases with large global impacts. Research on the pathogenesis and biology of these organisms is limited by economic and experimental constraints. Accordingly, studies of one parasite are frequently extrapolated to
Externí odkaz:
https://doaj.org/article/0b08b09adb444c8bbb911fd3cca3885c
Autor:
Jennifer L Guler, Daniel L Freeman, Vida Ahyong, Rapatbhorn Patrapuvich, John White, Ramesh Gujjar, Margaret A Phillips, Joseph DeRisi, Pradipsinh K Rathod
Publikováno v:
PLoS Pathogens, Vol 9, Iss 5, p e1003375 (2013)
Malaria drug resistance contributes to up to a million annual deaths. Judicious deployment of new antimalarials and vaccines could benefit from an understanding of early molecular events that promote the evolution of parasites. Continuous in vitro ch
Externí odkaz:
https://doaj.org/article/148359ae87cb4845b008ba25d4f7734c
Publikováno v:
mBio, Vol 14, Iss 3 (2023)
ABSTRACT Mounting evidence demonstrates that nutritional environment can alter pathogen drug sensitivity. While the rich media used for in vitro culture contains supraphysiological nutrient concentrations, pathogens encounter a relatively restrictive
Externí odkaz:
https://doaj.org/article/89801be502ff418daa6cd7929ded9d74
Autor:
Mukhethwa Munzhedzi, Elizabeth T. Rogawski McQuade, Jennifer L. Guler, Piper E. Shifflett, Sara Krivacsy, Rebecca Dillingham, Pascal O. Bessong
Publikováno v:
Malaria Journal, Vol 20, Iss 1, Pp 1-12 (2021)
Abstract Background Malaria remains a global health concern and is endemic in Limpopo, Mpumalanga and KwaZulu Natal Provinces of South Africa, which aims to eliminate malaria by 2025. Community engagement plays a significant role in improving the acc
Externí odkaz:
https://doaj.org/article/099f617a849247ebb190d5d6297a322b
Autor:
Kennedy Kassaza, Anna C. Long, Jennifer M. McDaniels, Mharlove Andre, Wasswa Fredrickson, Dan Nyehangane, Patrick Orikiriza, Darwin J. Operario, Joel Bazira, Juliet A. Mwanga-Amumpaire, Christopher C. Moore, Jennifer L. Guler, Yap Boum
Publikováno v:
Malaria Journal, Vol 20, Iss 1, Pp 1-10 (2021)
Abstract Background Chloroquine (CQ) resistance is conferred by mutations in the Plasmodium falciparum CQ resistance transporter (pfcrt). Following CQ withdrawal for anti-malarial treatment, studies across malaria-endemic countries have shown a range
Externí odkaz:
https://doaj.org/article/f152dc36a8e54087990ba77a54094ca6
Autor:
Shiwei Liu, Emily R. Ebel, Jane Kim, Nnenna Ene, Thomas Werner Anthony Braukmann, Ellen Yeh, Elizabeth S. Egan, Jennifer L. Guler
Publikováno v:
bioRxiv
Changes in the copy number of large genomic regions, termed copy number variations or CNVs, are an important adaptive strategy for malaria parasites. Numerous CNVs across thePlasmodium falciparumgenome contribute directly to drug resistance or impact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1e2ce410e560cab533aa8c49d5bd6c6
https://europepmc.org/articles/PMC9948948/
https://europepmc.org/articles/PMC9948948/
Autor:
Audrey C. Brown, Adam C Huckaby, Shiwei Liu, Ian E. Burbulis, Jennifer L. Guler, Christopher C. Moore, Michael J. McConnell
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-23 (2021)
Genome Medicine
Genome Medicine
Single-cell genomics is a rapidly advancing field; however, most techniques are designed for mammalian cells. We present a single-cell sequencing pipeline for an intracellular parasite, Plasmodium falciparum, with a small genome of extreme base conte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b6c7d5e91f239584ff9c30691b8a45
https://doaj.org/article/c0aa8fdcd77e47e2b462acb1a3425c1d
https://doaj.org/article/c0aa8fdcd77e47e2b462acb1a3425c1d
Autor:
Jennifer L. Guler, Ahmed Rasin, Audrey C. Brown, Walter Varhue, Nathan S. Swami, Armita Salahi, Karina Torres-Castro, XuHai Huang, Carlos Honrado
Publikováno v:
Lab Chip
Dielectrophoresis (DEP) enables the separation of cells based on subtle subcellular phenotypic differences by controlling the frequency of the applied field. However, current electrode-based geometries extend over a limited depth of the sample channe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b06e6e6c9ccb9fa4a08bc2004183fcc
https://doi.org/10.1039/d0lc01211d
https://doi.org/10.1039/d0lc01211d
Autor:
Sabrina A. Carter, Adam C Huckaby, Webster L. Santos, Molly D. Congdon, Jennifer M. McDaniels, Sabrina Lingeman, Pradipsinh K. Rathod, Audrey Francis, Jennifer L. Guler
Publikováno v:
Mol Microbiol
Molecular Microbiology
Molecular Microbiology
Extrachromosomal (ec) DNAs are genetic elements that exist separately from the genome. Since ecDNA can carry beneficial genes, they are a powerful adaptive mechanism in cancers and many pathogens. For the first time, we report ecDNA contributing to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d518c25919b4e31bf633acc54e4e30
https://doi.org/10.1111/mmi.14624
https://doi.org/10.1111/mmi.14624
Autor:
Jennifer L. Guler, Audrey C. Brown
Publikováno v:
Trends in Parasitology. 36:914-926
Research on Plasmodium parasites has driven breakthroughs in reducing malaria morbidity and mortality. Experimental analysis of in vivo/ex vivo versus in vitro samples serve unique roles in Plasmodium research. However, these distinctly different env
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7743ca6c0065b2656393be599e2a135
https://doi.org/10.1016/j.pt.2020.08.008
https://doi.org/10.1016/j.pt.2020.08.008