Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Jennifer L Gooch"'
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175242 (2017)
Calcineurin inhibitors are powerful immunosuppressants that revolutionized organ transplantation. However, non-immune effects of the calcineurin inhibitor, such as cyclosporine A (CsA), have significantly hindered their use. Specifically, nephrotoxic
Externí odkaz:
https://doaj.org/article/c147e34fcbcb432f8dc6efd319a6d8be
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62503 (2013)
Mice lacking the α isoform of the catalytic subunit of calcineurin (CnAα) were first reported in 1996 and have been an important model to understand the role of calcineurin in the brain, immune system, bones, muscle, and kidney. Research using the
Externí odkaz:
https://doaj.org/article/30a7edb8faca479882499c57a469ef4d
Autor:
Hemendra J. Vekaria, W. Brad Hubbard, Natalie E. Scholpa, Malinda L. Spry, Jennifer L. Gooch, Sydney J. Prince, Rick G. Schnellmann, Patrick G. Sullivan
Publikováno v:
Neurobiology of Disease, Vol 140, Iss , Pp 104866- (2020)
Traumatic brain injury (TBI) leads to acute necrosis at the site of injury followed by a sequence of secondary events lasting from hours to weeks and often years. Targeting mitochondrial impairment following TBI has shown improvements in brain mitoch
Externí odkaz:
https://doaj.org/article/d6b090ab489f43e39ac740c82e4dd014
Autor:
W Brad Hubbard, Malinda L Spry, Jennifer L Gooch, Amber L Cloud, Hemendra J Vekaria, Shawn Burden, David K Powell, Bruce A Berkowitz, Werner J Geldenhuys, Neil G Harris, Patrick G Sullivan
Publikováno v:
Brain
Pioglitazone, an FDA-approved compound, has been shown to target the novel mitochondrial protein mitoNEET and produce short-term neuroprotection and functional benefits following traumatic brain injury. To expand on these findings, we now investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfb74f9dfdf9b4d5f6756fa074c50c46
http://europepmc.org/articles/PMC8719838
http://europepmc.org/articles/PMC8719838
Autor:
Robert S. Hoover, Aswathy M Cheriyan, Hui Cai, Clintoria R. Williams, Monisha Mistry, Carla LaShannon Ellis, Abinash C. Mistry, Jennifer L. Gooch, Benjamin Ko, Jasmine M. Williams, Meagan Naraine, Rickta Mallick
Publikováno v:
American Journal of Physiology-Renal Physiology. 316:F646-F653
Zn2+ deficiency (ZnD) is a common comorbidity of many chronic diseases. In these settings, ZnD exacerbates hypertension. Whether ZnD alone is sufficient to alter blood pressure (BP) is unknown. To explore the role of Zn2+ in BP regulation, adult mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26b8b2d10af966816e64e820bf00f4c3
https://doi.org/10.1152/ajprenal.00487.2018
https://doi.org/10.1152/ajprenal.00487.2018
Autor:
Robert S. Hoover, Heping P Ma, Yun Bai, Valerie Linck, Adaku C. Ume, Clintoria R. Williams, Keyona N King, Cynthia E Francis, Aswathy M Cheriyan, Hui Cai, Jennifer L. Gooch
Publikováno v:
Am J Physiol Renal Physiol
Calcineurin inhibitors (CNIs) are vital immunosuppressive therapies in the management of inflammatory conditions. A long-term consequence is nephrotoxicity. In the kidneys, the primary, catalytic calcineurin (CnA) isoforms are CnAα and CnAβ. Althou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa454c03339475200e6df6ff3d7d5497
https://pubmed.ncbi.nlm.nih.gov/33615888
https://pubmed.ncbi.nlm.nih.gov/33615888
Autor:
Jennifer L. Gooch, Hemendra J. Vekaria, Rick G. Schnellmann, Patrick G. Sullivan, W. Brad Hubbard, Sydney J. Prince, Natalie E. Scholpa, Malinda Spry
Publikováno v:
Neurobiology of Disease, Vol 140, Iss, Pp 104866-(2020)
Traumatic brain injury (TBI) leads to acute necrosis at the site of injury followed by a sequence of secondary events lasting from hours to weeks and often years. Targeting mitochondrial impairment following TBI has shown improvements in brain mitoch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87feb3e7232cfa558992e264417bce0a
http://www.sciencedirect.com/science/article/pii/S0969996120301418
http://www.sciencedirect.com/science/article/pii/S0969996120301418
Autor:
Hemendra J, Vekaria, W Brad, Hubbard, Natalie E, Scholpa, Malinda L, Spry, Jennifer L, Gooch, Sydney J, Prince, Rick G, Schnellmann, Patrick G, Sullivan
Publikováno v:
Neurobiology of disease. 140
Traumatic brain injury (TBI) leads to acute necrosis at the site of injury followed by a sequence of secondary events lasting from hours to weeks and often years. Targeting mitochondrial impairment following TBI has shown improvements in brain mitoch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4924b3896e1128ba872ad1703f735fcc
https://pubmed.ncbi.nlm.nih.gov/32289370
https://pubmed.ncbi.nlm.nih.gov/32289370
Publikováno v:
Anesthesia and analgesia. 129(1)
Background Clinical studies implicate the perioperative period in cognitive complications, and increasing experimental evidence shows that the anesthetic agents can affect neuronal processes that underpin learning and memory. Calcineurin, a Ca-depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c24d19fa3c95bddcef78d6764a464d45
https://pubmed.ncbi.nlm.nih.gov/31082969
https://pubmed.ncbi.nlm.nih.gov/31082969
Autor:
Robert S. Hoover, Clintoria R. Williams, Mirandy S. Li, Carla LaShannon Ellis, Jennifer L. Gooch, Sherry Adesina
Publikováno v:
American Journal of Physiology-Cell Physiology. 312:C47-C55
Zn2+ deficiency (ZnD) is comorbid with chronic kidney disease and worsens kidney complications. Oxidative stress is implicated in the detrimental effects of ZnD. However, the sources of oxidative stress continue to be identified. Since NADPH oxidases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda2c9f5db9ed3dbf5f0c93c59d768c8
https://doi.org/10.1152/ajpcell.00208.2016
https://doi.org/10.1152/ajpcell.00208.2016