Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Jennifer L Furman"'
Autor:
Diana M Sama, Hafiz Mohmmad Abdul, Jennifer L Furman, Irina A Artiushin, David E Szymkowski, Stephen W Scheff, Christopher M Norris
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e38170 (2012)
The role of tumor necrosis factor α (TNF) in neural function has been investigated extensively in several neurodegenerative conditions, but rarely in brain aging, where cognitive and physiologic changes are milder and more variable. Here, we show th
Externí odkaz:
https://doaj.org/article/9070eedaf2674801b42def61428bc4c7
Autor:
Songmao Zheng, David Polidori, Yuanping Wang, Brian Geist, Xiefan Lin‐Schmidt, Jennifer L. Furman, Serena Nelson, Andrea R. Nawrocki, Simon A. Hinke
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 8, Pp 1431-1444 (2023)
Abstract Growth Differentiation Factor‐15 (GDF15) is a circulating polypeptide linked to cellular stress and metabolic adaptation. GDF15's half‐life is ~3 h and activates the glial cell line‐derived neurotrophic factor family receptor alpha‐l
Externí odkaz:
https://doaj.org/article/c585a6f12b244dfba472ff6c70f4a613
Autor:
Songmao Zheng, David Polidori, Yuanping Wang, Brian Geist, Xiefan Lin‐Schmidt, Jennifer L. Furman, Serena Nelson, Andrea R. Nawrocki, Simon A. Hinke
Publikováno v:
Clinical and Translational Science.
Autor:
Songmao Zheng, David Polidori, Yuanping Wang, Brian Geist, Xiefan Lin-Schmidt, Jennifer L. Furman, Serena Nelson, Andrea R. Nawrocki, Simon A. Hinke
GDF15 is a circulating polypeptide associated with cellular stress, and recently linked to metabolic adaptation. GDF15 has a half-life of approximately 3 hours in and acts at the GFRAL receptor selectively expressed in the area postrema. To character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88e026a2285071a87eb1de41ecc7ec4a
https://doi.org/10.1101/2022.12.05.519153
https://doi.org/10.1101/2022.12.05.519153
Autor:
Jennifer L. Furman, Eun Suk Song, Tritia R. Yamasaki, Marc I. Diamond, Bryant W. Su, Dhruva Dhavale, Paul T. Kotzbauer, Brandon B. Holmes, Nigel J. Cairns
Publikováno v:
The Journal of Biological Chemistry
Parkinson's disease (PD) and multiple system atrophy (MSA) are distinct clinical syndromes characterized by the pathological accumulation of α-synuclein (α-syn) protein fibrils in neurons and glial cells. These disorders and other neurodegenerative
Autor:
Gustavo C. Medeiros, Madhukar H. Trivedi, Manish K. Jha, Andrew H. Czysz, Jennifer L. Furman, Joseph M. Trombello, Thomas J. Carmody, A. John Rush, Crystal Cooper
Publikováno v:
Depress Anxiety
BACKGROUND Heterogeneity in major depressive disorder (MDD) is well recognized but not well understood. Core depressive features are reward and emotional symptoms, which reflect dysfunctions in the positive valence (PV) and negative valence (NV) syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef858079ccff253e8044c4ae7cda5714
https://europepmc.org/articles/PMC9900948/
https://europepmc.org/articles/PMC9900948/
Autor:
Philipp E. Scherer, Brittany L. Mason, Thomas J. Carmody, Abigail A. Soyombo, Jennifer L. Furman, Madhukar H. Trivedi, Manish K. Jha, Andrew H. Czysz
Publikováno v:
Personalized Medicine in Psychiatry. :1-7
Background Major depressive disorder (MDD) is often comorbid with metabolic diseases such as obesity, cardiovascular disease, and type 2 diabetes. A potential link between these disorders is adiponectin, an adipocyte-derived circulating hormone with
Autor:
Chen-Ni Chin, Thai Dinh, Michael J. Hunter, Serena M. Nelson, Jose Antonio Chavez, Stephen C Beck, Anthony A. Armstrong, Jennifer L. Furman, Cassandre R. Cavanaugh, Shamina M. Rangwala, Chichi Huang, Tanesha Cash-Mason, Xiefan Lin-Schmidt, Victoria J South, Shannon E. Mullican
Publikováno v:
Nature Medicine. 23:1150-1157
Growth differentiation factor 15 (GDF15), a distant member of the transforming growth factor (TGF)-β family, is a secreted protein that circulates as a 25-kDa dimer. In humans, elevated GDF15 correlates with weight loss, and the administration of GD
Autor:
Susan D. Kraner, Melanie M. Pleiss, Jennifer L. Furman, M. Paul Murphy, Christopher M. Norris, Greg A. Gerhardt, Jorge E. Quintero, Mark A. Lovell, Irina A. Artiushin, Pradoldej Sompol, Tina L. Beckett, Linda A. Simmerman, Seth R. Batten
Publikováno v:
The Journal of Neuroscience. 37:6132-6148
Hyperexcitable neuronal networks are mechanistically linked to the pathologic and clinical features of Alzheimer's disease (AD). Astrocytes are a primary defense against hyperexcitability, but their functional phenotype during AD is poorly understood
Autor:
Cherise Chin Fatt, Betsy D. Kennard, Tracy L. Greer, Brittany L. Mason, Taryn L. Mayes, Abu Minhajuddin, Jennifer L. Furman, Bharathi S. Gadad, Guanghua Xiao, Jennifer L. Hughes, Madhukar H. Trivedi, Manish K. Jha, Ling Cai, Graham J. Emslie
Publikováno v:
Psychoneuroendocrinology. 111
Immune system dysfunction has been implicated in the pathophysiology of suicide behavior. Here, we conducted an exploratory analysis of immune profile differences of three groups of adolescents and young adults (ages 10-25 years): healthy controls (n