Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Jennifer L Eitson"'
Autor:
Sofya S Perelman, Michael E Abrams, Jennifer L Eitson, Didi Chen, Alyssa Jimenez, Marcel Mettlen, John W Schoggins, Neal M Alto
Publikováno v:
PLoS Pathogens, Vol 12, Iss 12, p e1006102 (2016)
The type I interferon (IFN) activated transcriptional response is a critical antiviral defense mechanism, yet its role in bacterial pathogenesis remains less well characterized. Using an intracellular pathogen Listeria monocytogenes (Lm) as a model b
Externí odkaz:
https://doaj.org/article/f3851d44fbcc40029b201bfa961e9914
Autor:
Daniel L. Kober, Marley C. Caballero Van Dyke, Jennifer L. Eitson, Ian N. Boys, Matthew B. McDougal, Daniel M. Rosenbaum, John W. Schoggins
Publikováno v:
mBio, Vol 15, Iss 6 (2024)
ABSTRACT The rapid evolution of SARS-CoV-2 variants highlights the need for new therapies to prevent disease spread. SARS-CoV-2, like SARS-CoV-1, uses the human cell surface protein angiotensin-converting enzyme 2 (ACE2) as its native receptor. Here,
Externí odkaz:
https://doaj.org/article/bb44b7e8a55249a1bd0f9458bb7da61a
Autor:
Serkan Belkaya, Robert L Silge, Ashley R Hoover, Jennifer J Medeiros, Jennifer L Eitson, Amy M Becker, M Teresa de la Morena, Rhonda S Bassel-Duby, Nicolai S C van Oers
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27580 (2011)
BackgroundPhysiological stress evokes rapid changes in both the innate and adaptive immune response. Immature αβ T cells developing in the thymus are particularly sensitive to stress, with infections and/or exposure to lipopolysaccharide or glucoco
Externí odkaz:
https://doaj.org/article/d2b98dd1322f41de97876ff8a1428aca
Autor:
Mahmoud S. Ahmed, Ayman B. Farag, Ian N. Boys, Ping Wang, Ivan Menendez-Montes, Ngoc Uyen Nhi Nguyen, Jennifer L. Eitson, Maikke B. Ohlson, Wenchun Fan, Matthew B. McDougal, Katrina Mar, Suwannee Thet, Francisco Ortiz, Soo Young Kim, Ashley Solmonson, Noelle S. Williams, Andrew Lemoff, Ralph J. DeBerardinis, John W. Schoggins, Hesham A. Sadek
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 162, Iss , Pp 114614- (2023)
The continuing heavy toll of the COVID-19 pandemic necessitates development of therapeutic options. We adopted structure-based drug repurposing to screen FDA-approved drugs for inhibitory effects against main protease enzyme (Mpro) substrate-binding
Externí odkaz:
https://doaj.org/article/23a65e76569a486bbf633ca2ee9aedab
Autor:
Maikke B. Ohlson, Jennifer L. Eitson, Alexandra I. Wells, Ashwani Kumar, Seoyeon Jang, Chunyang Ni, Chao Xing, Michael Buszczak, John W. Schoggins
Publikováno v:
mBio, Vol 14, Iss 2 (2023)
ABSTRACT Viruses are known to co-opt host machinery for translation initiation, but less is known about which host factors are required for the formation of ribosomes used to synthesize viral proteins. Using a loss-of-function CRISPR screen, we show
Externí odkaz:
https://doaj.org/article/283e63e8f9ab43d9898e630d22d7fa87
Autor:
Frederick Rehfeld, Jennifer L. Eitson, Maikke B. Ohlson, Tsung-Cheng Chang, John W. Schoggins, Joshua T. Mendell
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112076- (2023)
Summary: During translation of the genomic RNA of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative virus in the COVID-19 pandemic, host ribosomes undergo programmed ribosomal frameshifting (PRF) at a conserved structural el
Externí odkaz:
https://doaj.org/article/c5ee75d2bea24b9592eec718af1d304e
Autor:
Katrina B. Mar, Marley C. Van Dyke, Alexandra H. Lopez, Jennifer L. Eitson, Wenchun Fan, Natasha W. Hanners, Bret M. Evers, John M. Shelton, John W. Schoggins
Publikováno v:
bioRxiv
LY6E is an antiviral protein that inhibits coronavirus entry. Its expression in immune cells allows mice to control murine coronavirus infection. However, it is not known which immune cell subsets mediate this control or whether LY6E protects mice fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238672eef8aca9cd981c569cb50cb23a
https://europepmc.org/articles/PMC9900800/
https://europepmc.org/articles/PMC9900800/
Autor:
Maikke B. Ohlson, Ashwani Kumar, Jennifer L. Eitson, Seoyeon Jang, Chunyang Ni, Chao Xing, Michael Buszczak, John W. Schoggins
Viruses are known to co-opt host machinery for translation initiation, but less is known about which host factors are required for the formation of ribosomes used to synthesize viral proteins. Using a loss of function CRISPR screen, we show that synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f982e66fb88561a35fe4c7ea0e80be16
https://doi.org/10.1101/2022.11.12.515717
https://doi.org/10.1101/2022.11.12.515717
Autor:
Gina J. Park, Adam Osinski, Genaro Hernandez, Jennifer L. Eitson, Abir Majumdar, Marco Tonelli, Katie Henzler-Wildman, Krzysztof Pawłowski, Zhe Chen, Yang Li, John W. Schoggins, Vincent S. Tagliabracci
The RNA genome of SARS-CoV-2 contains a 5′ cap that facilitates the translation of viral proteins, protection from exonucleases and evasion of the host immune response1–4. How this cap is made in SARS-CoV-2 is not completely understood. Here we r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac2dadecb9a2d6597f726d81696a6c48
https://doi.org/10.1101/2022.02.07.479471
https://doi.org/10.1101/2022.02.07.479471
Autor:
Natasha W. Hanners, Katrina B. Mar, Ian N. Boys, Jennifer L. Eitson, Pamela C. De La Cruz-Rivera, R. Blake Richardson, Wenchun Fan, Mary Wight-Carter, John W. Schoggins
Publikováno v:
Proc Natl Acad Sci U S A
Flaviviruses such as Zika virus and West Nile virus have the potential to cause severe neuropathology if they invade the central nervous system. The type I interferon response is well characterized as contributing to control of flavivirus-induced neu