Zobrazeno 1 - 10
of 307
pro vyhledávání: '"Jennifer L, Stow"'
Autor:
Belamy B. Cheung, Ritu Mittra, Jayne Murray, Qian Wang, Janith A. Seneviratne, Mukesh Raipuria, Iris Poh Ling Wong, David Restuccia, Andrew Gifford, Alice Salib, Selina Sutton, Libby Huang, Parisa Vahidi Ferdowsi, Joanna Tsang, Eric Sekyere, Chelsea Mayoh, Lin Luo, Darren L. Brown, Jennifer L. Stow, Shizhen Zhu, Richard J. Young, Benjamin J. Solomon, Stephane Chappaz, Benjamin Kile, Andrew Kueh, Marco J. Herold, Douglas J. Hilton, Tao Liu, Murray D. Norris, Michelle Haber, Daniel R. Carter, Michael W. Parker, Glenn M. Marshall
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract MYCN amplification predicts poor prognosis in childhood neuroblastoma. To identify MYCN oncogenic signal dependencies we performed N-ethyl-N-nitrosourea (ENU) mutagenesis on the germline of neuroblastoma-prone TH-MYCN transgenic mice to gene
Externí odkaz:
https://doaj.org/article/7aab45a11a28499aa2b12d59ee58078b
Autor:
Abdullah A. Tarique, Neeraj Tuladhar, Dean Kelk, Nelufa Begum, Richard M. Lucas, Lin Luo, Jennifer L. Stow, Claire E. Wainwright, Scott C. Bell, Peter D. Sly, Emmanuelle Fantino
Publikováno v:
Cells, Vol 13, Iss 2, p 166 (2024)
Background: Azithromycin (AZM) is widely being used for treating patients with cystic fibrosis (pwCF) following clinical trials demonstrating improved lung function and fewer incidents of pulmonary exacerba-tions. While the precise mechanisms remain
Externí odkaz:
https://doaj.org/article/ab3ca60e7c704385958293d1d99c96ce
Autor:
James G. Lefevre, Yvette W. H. Koh, Adam A. Wall, Nicholas D. Condon, Jennifer L. Stow, Nicholas A. Hamilton
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-26 (2021)
Abstract Background With recent advances in microscopy, recordings of cell behaviour can result in terabyte-size datasets. The lattice light sheet microscope (LLSM) images cells at high speed and high 3D resolution, accumulating data at 100 frames/se
Externí odkaz:
https://doaj.org/article/c5c8488c33194c0481b9480c83260689
Autor:
Thao Thanh Tran, Carmen D. Mathmann, Marcela Gatica-Andrades, Rachel F. Rollo, Melanie Oelker, Johanna K. Ljungberg, Tam T. K. Nguyen, Alina Zamoshnikova, Lalith K. Kummari, Orry J. K. Wyer, Katharine M. Irvine, Javier Melo-Bolívar, Annette Gross, Darren Brown, Jeffrey Y. W. Mak, David P. Fairlie, Karl A. Hansford, Matthew A. Cooper, Rabina Giri, Veronika Schreiber, Shannon R. Joseph, Fiona Simpson, Timothy C. Barnett, Jörgen Johansson, Wendy Dankers, James Harris, Timothy J. Wells, Ronan Kapetanovic, Matthew J. Sweet, Eleanor A. Latomanski, Hayley J. Newton, Romain J. R. Guérillot, Abderrahman Hachani, Timothy P. Stinear, Sze Ying Ong, Yogeswari Chandran, Elizabeth L. Hartland, Bostjan Kobe, Jennifer L. Stow, A. Elisabeth Sauer-Eriksson, Jakob Begun, Jessica C. Kling, Antje Blumenthal
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1 (2022)
A hallmark of Listeria (L.) monocytogenes pathogenesis is bacterial escape from maturing entry vacuoles, which is required for rapid bacterial replication in the host cell cytoplasm and cell-to-cell spread. The bacterial transcriptional activator Prf
Externí odkaz:
https://doaj.org/article/66dd0ab76b8e4e24a1aee04a59d0cdfa
Autor:
Kaustav Das Gupta, Melanie R. Shakespear, James E.B. Curson, Ambika M.V. Murthy, Abishek Iyer, Mark P. Hodson, Divya Ramnath, Vikas A. Tillu, Jessica B. von Pein, Robert C. Reid, Kathryn Tunny, Daniel M. Hohenhaus, Shayli Varasteh Moradi, Gregory M. Kelly, Takumi Kobayashi, Jennifer H. Gunter, Alexander J. Stevenson, Weijun Xu, Lin Luo, Alun Jones, Wayne A. Johnston, Antje Blumenthal, Kirill Alexandrov, Brett M. Collins, Jennifer L. Stow, David P. Fairlie, Matthew J. Sweet
Publikováno v:
Cell Reports, Vol 30, Iss 8, Pp 2712-2728.e8 (2020)
Summary: Histone deacetylases (HDACs) drive innate immune cell-mediated inflammation. Here we identify class IIa HDACs as key molecular links between Toll-like receptor (TLR)-inducible aerobic glycolysis and macrophage inflammatory responses. A prote
Externí odkaz:
https://doaj.org/article/499080960e35403c84db1073e30bdd67
Autor:
Lin Luo, Adam A. Wall, Samuel J. Tong, Yu Hung, Zhijian Xiao, Abdullah A. Tarique, Peter D. Sly, Emmanuelle Fantino, María-Paz Marzolo, Jennifer L. Stow
Publikováno v:
Cell Reports, Vol 24, Iss 11, Pp 3033-3044 (2018)
Summary: The multi-ligand endocytic receptor, low-density lipoprotein-receptor-related protein 1 (LRP1), has anti-inflammatory roles in disease. Here, we reveal that pathogen-activated Toll-like receptors (TLRs) activate LRP1 in human and mouse prima
Externí odkaz:
https://doaj.org/article/a9115c70a128482dbd96c2e6c60f16f1
Autor:
Marija Kojic, Monika Gaik, Bence Kiska, Anna Salerno-Kochan, Sarah Hunt, Angelo Tedoldi, Sergey Mureev, Alun Jones, Belinda Whittle, Laura A. Genovesi, Christelle Adolphe, Darren L. Brown, Jennifer L. Stow, Kirill Alexandrov, Pankaj Sah, Sebastian Glatt, Brandon J. Wainwright
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Elp6 is a component of the Elongator complex that regulates tRNAs and translation. Here the authors identify a mutation in the Elp6 gene that contributes to the cerebellar ataxia-like phenotype in a mutant mouse.
Externí odkaz:
https://doaj.org/article/abbd7a3dce6a4cee904088b04300ff36
Autor:
Mercedes Monteleone, Amanda C. Stanley, Kaiwen W. Chen, Darren L. Brown, Jelena S. Bezbradica, Jessica B. von Pein, Caroline L. Holley, Dave Boucher, Melanie R. Shakespear, Ronan Kapetanovic, Verena Rolfes, Matthew J. Sweet, Jennifer L. Stow, Kate Schroder
Publikováno v:
Cell Reports, Vol 24, Iss 6, Pp 1425-1433 (2018)
Summary: IL-1β requires processing by caspase-1 to generate the active, pro-inflammatory cytokine. Acute IL-1β secretion from inflammasome-activated macrophages requires caspase-1-dependent GSDMD cleavage, which also induces pyroptosis. Mechanisms
Externí odkaz:
https://doaj.org/article/a43be258b327448fa6e72d48bc208d26
Autor:
Jennifer L. Stow, Matthew J. Sweet
Publikováno v:
Journal of Cell Biology. 222
The exuberant phagocytosis of apoptotic cell corpses by macrophages in Drosophila embryos creates highly oxidative environments. Stow and Sweet discuss work from Clemente and Weavers (2023. J. Cell Biol.https://doi.org/10.1083/jcb.202203062) showing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8795551eb9404a598d5f7eda4523d71
https://doi.org/10.1083/jcb.202305036
https://doi.org/10.1083/jcb.202305036
Autor:
James E.B. Curson, Liping Liu, Lin Luo, Timothy W. Muusse, Richard M. Lucas, Kimberley S. Gunther, Parimala R. Vajjhala, Rishika Abrol, Alun Jones, Ronan Kapetanovic, Katryn J. Stacey, Jennifer L. Stow, Matthew J. Sweet
Publikováno v:
European Journal of Immunology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19b6939b783780eade90686d3c9efcfe
https://doi.org/10.1002/eji.202250056
https://doi.org/10.1002/eji.202250056