Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Jennifer L, Estall"'
Autor:
Mohamed N. Abdelnabi, Manuel Flores Molina, Geneviève Soucy, Vincent Quoc-Huy Trinh, Nathalie Bédard, Sabrina Mazouz, Nathalie Jouvet, Jessica Dion, Sarah Tran, Marc Bilodeau, Jennifer L. Estall, Naglaa H. Shoukry
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 14, Iss 6, Pp 1269-1294 (2022)
Background & Aims: Nonalcoholic fatty liver disease (NAFLD) is a major health problem with complex pathogenesis. Although sex differences in NAFLD pathogenesis have been reported, the mechanisms underlying such differences remain understudied. Interl
Externí odkaz:
https://doaj.org/article/414b2226207c4b00976d3dd01d78d00a
Autor:
Mathieu Paquette, Ming Yan, Josué M. J. Ramírez-Reyes, Leeanna El-Houjeiri, Marco Biondini, Catherine R. Dufour, Hyeonju Jeong, Alain Pacis, Vincent Giguère, Jennifer L. Estall, Peter M. Siegel, Étienne Audet-Walsh, Arnim Pause
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Non-alcoholic fatty liver disease (NAFLD) is the most frequent liver disease worldwide and can progress to non-alcoholic steatohepatitis (NASH), which is characterized by triglyceride accumulation, inflammation, and fibrosis. No pharmacologi
Externí odkaz:
https://doaj.org/article/1475e426b13d4372960b3695a52f08dd
Autor:
Mélissa Léveillé, Aurèle Besse-Patin, Nathalie Jouvet, Aysim Gunes, Sarah Sczelecki, Stewart Jeromson, Naveen P. Khan, Cindy Baldwin, Annie Dumouchel, Jorge C. Correia, Paulo R. Jannig, Jonathan Boulais, Jorge L. Ruas, Jennifer L. Estall
Publikováno v:
Molecular Metabolism, Vol 34, Iss , Pp 72-84 (2020)
Objective: The liver is regularly exposed to changing metabolic and inflammatory environments. It must sense and adapt to metabolic need while balancing resources required to protect itself from insult. Peroxisome proliferator activated receptor gamm
Externí odkaz:
https://doaj.org/article/c06589cb7e004ec49cb98361c3eaaf51
Autor:
Duarte M. S. Ferreira, Arthur J. Cheng, Leandro Z. Agudelo, Igor Cervenka, Thomas Chaillou, Jorge C. Correia, Margareta Porsmyr-Palmertz, Manizheh Izadi, Alicia Hansson, Vicente Martínez-Redondo, Paula Valente-Silva, Amanda T. Pettersson-Klein, Jennifer L. Estall, Matthew M. Robinson, K. Sreekumaran Nair, Johanna T. Lanner, Jorge L. Ruas
Publikováno v:
Skeletal Muscle, Vol 9, Iss 1, Pp 1-19 (2019)
Abstract Background Skeletal muscle mass and strength are crucial determinants of health. Muscle mass loss is associated with weakness, fatigue, and insulin resistance. In fact, it is predicted that controlling muscle atrophy can reduce morbidity and
Externí odkaz:
https://doaj.org/article/2f827301045e4b2e8bc503169f19361b
Autor:
Tomi Tuomainen, Nikolay Naumenko, Maija Mutikainen, Anastasia Shakirzyanova, Sarah Sczelecki, Jennifer L. Estall, Jorge L. Ruas, Pasi Tavi
Publikováno v:
Cells, Vol 11, Iss 19, p 2944 (2022)
Transcriptional coactivator PGC-1α is a main regulator of cardiac energy metabolism. In addition to canonical PGC-1α1, other PGC-1α isoforms have been found to exert specific biological functions in a variety of tissues. We investigated the expres
Externí odkaz:
https://doaj.org/article/44d1db518dfc4eeda0b5423e93154bda
Autor:
Yannick Cyr, Valérie Lamantia, Simon Bissonnette, Melanie Burnette, Aurèle Besse‐Patin, Annie Demers, Martin Wabitsch, Michel Chrétien, Gaétan Mayer, Jennifer L. Estall, Maya Saleh, May Faraj
Publikováno v:
Physiological Reports, Vol 9, Iss 3, Pp n/a-n/a (2021)
Abstract Background LDL‐cholesterol lowering variants that upregulate receptor uptake of LDL, such as in PCSK9 and HMGCR, are associated with diabetes via unclear mechanisms. Activation of the NLRP3 inflammasome/interleukin‐1 beta (IL‐1β) path
Externí odkaz:
https://doaj.org/article/55e8b3a5fa1f4be4a5bf58b8cf9bb904
Autor:
James M. Eng, Jennifer L. Estall
Publikováno v:
Cells, Vol 10, Iss 7, p 1805 (2021)
Non-alcoholic fatty liver disease (NAFLD) affects approximately 1 in 4 people worldwide and is a major burden to health care systems. A major concern in NAFLD research is lack of confidence in pre-clinical animal models, raising questions regarding t
Externí odkaz:
https://doaj.org/article/08a17662272a496991f273c6397fc019
Autor:
Khalil Bouyakdan, Cindy Baldwin, Scott A. Campbell, Maureen Gannon, Thierry Alquier, Vincent Poitout, Nathalie Jouvet, Jennifer L. Estall, Shannon E. Townsend
Publikováno v:
Diabetes
Controllable genetic manipulation is an indispensable tool in research, greatly advancing our understanding of cell biology and physiology. However in β-cells, transgene silencing, low inducibility, ectopic expression, and off-targets effects are pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8411cb5388bccac9f8e854d716a3e775
https://doi.org/10.2337/db21-0147
https://doi.org/10.2337/db21-0147
Autor:
Josué M. J. Ramírez-Reyes, Ming Yan, Jennifer L. Estall, Catherine R. Dufour, Arnim Pause, Alain Pacis, Étienne Audet-Walsh, Hyeonju Jeong, Mathieu Paquette, Vincent Giguère, Leeanna El-Houjeiri, Marco Biondini, Peter M. Siegel
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Scientific Reports
Non-alcoholic fatty liver disease (NAFLD) is the most frequent liver disease worldwide and can progress to non-alcoholic steatohepatitis (NASH), which is characterized by triglyceride accumulation, inflammation, and fibrosis. No pharmacological agent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cd6e21648044a6d82f5fd41abef3598
https://doaj.org/article/1475e426b13d4372960b3695a52f08dd
https://doaj.org/article/1475e426b13d4372960b3695a52f08dd
Autor:
Daniel Oropeza, Nathalie Jouvet, Khalil Bouyakdan, Gabrielle Perron, Lea-Jeanne Ringuette, Louis H. Philipson, Robert S. Kiss, Vincent Poitout, Thierry Alquier, Jennifer L. Estall
Publikováno v:
Molecular Metabolism, Vol 4, Iss 11, Pp 811-822 (2015)
Objectives: Peroxisome proliferator-activated receptor γ coactivator 1 (PPARGCA1, PGC-1) transcriptional coactivators control gene programs important for nutrient metabolism. Islets of type 2 diabetic subjects have reduced PGC-1α expression and thi
Externí odkaz:
https://doaj.org/article/1935dd6aa91c47d5ae94162df6f8e61d