Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Jennifer L, Ather"'
Autor:
Bristy Sabikunnahar, Sydney Caldwell, Stella Varnum, Tyler Hogan, Karolyn G. Lahue, Birgit Rathkolb, Raffaele Gerlini, Nathalia R. V. Dragano, Antonio Aguilar‐Pimentel, Martin Irmler, Adrián Sanz‐Moreno, Patricia daSilva‐Buttkus, German Mouse Clinic Consortium, Johannes Beckers, Eckhard Wolf, Valerie Gailus‐Durner, Helmut Fuchs, Martin Hrabe de Angelis, Jennifer L. Ather, Matthew E. Poynter, Dimitry N. Krementsov
Publikováno v:
Physiological Reports, Vol 12, Iss 1, Pp n/a-n/a (2024)
Abstract Obesity is a global health problem characterized by excessive fat accumulation, driven by adipogenesis and lipid accumulation. Long non‐coding RNAs (lncRNAs) have recently been implicated in regulating adipogenesis and adipose tissue funct
Externí odkaz:
https://doaj.org/article/737caf1a9abf472aaf1a165f9f9cba24
Autor:
Aida Habibovic, Milena Hristova, Carolyn R. Morris, Miao-Chong Joy Lin, Litiele C. Cruz, Jennifer L. Ather, Miklós Geiszt, Vikas Anathy, Yvonne M. W. Janssen-Heininger, Matthew E. Poynter, Anne E. Dixon, Albert van der Vliet
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 324:L228-L242
More than 50% of people with asthma in the United States are obese, and obesity often worsens symptoms of allergic asthma and impairs response to treatment. Based on previously established roles of the epithelial NADPH oxidase DUOX1 in allergic airwa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1486923fdd005d04f6e51b19c5b06d38
https://doi.org/10.1152/ajplung.00331.2022
https://doi.org/10.1152/ajplung.00331.2022
Autor:
Laura R. Hoyt, Matthew J. Randall, Jennifer L. Ather, Daniel P. DePuccio, Christopher C. Landry, Xi Qian, Yvonne M. Janssen-Heininger, Albert van der Vliet, Anne E. Dixon, Eyal Amiel, Matthew E. Poynter
Publikováno v:
Redox Biology, Vol 12, Iss , Pp 883-896 (2017)
Alcohol use disorders are common both in the United States and globally, and are associated with a variety of co-morbid, inflammation-linked diseases. The pathogenesis of many of these ailments are driven by the activation of the NLRP3 inflammasome,
Externí odkaz:
https://doaj.org/article/31019ce6d6fc49589bc4750f96e96c8b
Autor:
Carolyn R. Morris, Aida Habibovic, Christopher M. Dustin, Caspar Schiffers, Miao-Chong Lin, Jennifer L. Ather, Yvonne M.W. Janssen-Heininger, Matthew E. Poynter, Olaf Utermohlen, Martin Krönke, Albert van der Vliet
Publikováno v:
Mucosal Immunology. 15:977-989
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2319a51bc896d0ff659e368c796d228e
https://doi.org/10.1038/s41385-022-00530-x
https://doi.org/10.1038/s41385-022-00530-x
Autor:
Madeleine M. Mank, Leah F. Reed, V. Amanda Fastiggi, Paola E. Peña-García, Laura R. Hoyt, Katherine E. Van Der Vliet, Jennifer L. Ather, Matthew E. Poynter
Publikováno v:
The journal of allergy and clinical immunology. Global. 1(4)
Individuals with allergic asthma exhibit lung inflammation and remodeling accompanied by methacholine hyperresponsiveness manifesting in proximal airway narrowing and distal lung tissue collapsibility, and they can present with a range of mild-to-sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::544610423508822c2b3d5a6103beb3e8
https://pubmed.ncbi.nlm.nih.gov/36466740
https://pubmed.ncbi.nlm.nih.gov/36466740
Autor:
Jennifer L Ather, Matthew E Poynter
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192352 (2018)
Serum amyloid A (SAA) is an apolipoprotein that is robustly upregulated in numerous inflammatory diseases and has been implicated as a candidate pro-inflammatory mediator. However, studies comparing endogenous SAAs and recombinant forms of the acute
Externí odkaz:
https://doaj.org/article/dde00f80c6ec44558ed3bd80be1a6ae2
Autor:
Leah F Reed, Katherine E Van Der Vliet, Anne E. Dixon, Madeleine M Mank, Matthew E. Poynter, Jennifer L. Ather
Publikováno v:
Am J Physiol Regul Integr Comp Physiol
Although recognized as an important endocrine organ, little is known about the mechanisms through which adipose tissue can regulate inflammatory responses in distant tissues, such as lung that are affected by obesity. To explore potential mechanisms,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1adc029239627d27040ef7e79a0956d
https://doi.org/10.1152/ajpregu.00316.2020
https://doi.org/10.1152/ajpregu.00316.2020
Autor:
Madeleine M. Mank, Leah F. Reed, Camille J. Walton, Madison L. T. Barup, Jennifer L. Ather, Matthew E. Poynter
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Obese asthmatics tend to have severe, poorly controlled disease and exhibit methacholine hyperresponsiveness manifesting in proximal airway narrowing and distal lung tissue collapsibility. Substantial weight loss in obese asthmatics or in mouse model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efec1d30410b3f76c03ea04f9bd72cfc
https://europepmc.org/articles/PMC8782644/
https://europepmc.org/articles/PMC8782644/
Autor:
Carolyn R, Morris, Aida, Habibovic, Christopher M, Dustin, Caspar, Schiffers, Miao-Chong, Lin, Jennifer L, Ather, Yvonne M W, Janssen-Heininger, Matthew E, Poynter, Olaf, Utermohlen, Martin, Krönke, Albert, van der Vliet
Publikováno v:
Mucosal immunology. 15(5)
The NADPH oxidase DUOX1 contributes to epithelial production of alarmins, including interleukin (IL)-33, in response to injurious triggers such as airborne protease allergens, and mediates development of mucus metaplasia and airway remodeling in chro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::699e08745388a54bf59850b09ead5296
https://pubmed.ncbi.nlm.nih.gov/35654836
https://pubmed.ncbi.nlm.nih.gov/35654836
Autor:
Matthew J Randall, Shannon F Kostin, Edward J Burgess, Laura R Hoyt, Jennifer L Ather, Lennart K Lundblad, Matthew E Poynter
Publikováno v:
Frontiers in Endocrinology, Vol 5 (2015)
Airway epithelial NF-kB activation is observed in asthmatic subjects and is a cause of airway inflammation in mouse models of allergic asthma. Combination therapy with inhaled short-acting b2-agonists and corticosteroids significantly improves lung f
Externí odkaz:
https://doaj.org/article/77fb0ab0a86548889db97ae18df75815