Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Jennifer Kuehne-Willmore"'
Autor:
Marvin M. Hansen, Jennifer Kuehne-Willmore, Amy C. DeBaillie, Molly Harding, Joseph R. Martinelli, Daniel J. Jarmer, Michael J. McCulley, Dominique Huber, Michael E. Laurila, Thomas J. Martin, David W. Hoard, Theo Zweifel, Ryan J. Linder, Stanley P. Kolis, Nikolay Zaborenko, Enver Arslantas, Rachel N. Richey, Derek R. Starkey, Thomas Kull, Adrienne Hollister, Jeffrey A. Ward, Andrea L. Frederick
Publikováno v:
Organic Process Research & Development. 19:1214-1230
An efficient synthesis of LY2886721 (1) in five steps and 46% overall yield from the chiral nitrone cycloadduct 2 is presented. Minimizing formation of a des-fluoro impurity during hydrogenolysis to cleave the isoxazolidine ring and remove the benzyl
Publikováno v:
Journal of Pharmaceutical Sciences. 101:2364-2371
The unit dose uniformity (UDU) of low-dose drug products can be affected by active pharmaceutical ingredient (API) particle size. UDU relative standard deviation increases as the fraction of large API particles increases and/or as the unit dose decre
Autor:
Xuebao Wang, Robert E. Waltermire, Jennifer Kuehne-Willmore, Alan Braem, Zhinong Gao, Miguel Rosingana, John Castoro, Douglas D. McLeod, Albert J. DelMonte, Kirsten D. Gesenberg, Kevin P. Girard, Yu Fan
Publikováno v:
Organic Process Research & Development. 14:553-561
The process development and the kilogram-scale synthesis of BMS-587101 (1) are described. The synthesis features a [3 + 2] azomethine ylide cycloaddition to efficiently build the spirocyclic core in a diastereoselective fashion followed by a classica