Further Extension of Lifespan by Unc-43/CaMKII and Egl-8/PLCβ Mutations in Germline-Deficient Caenorhabditis elegans

Autor: Hildegard I. D. Mack, Laura G. Buck, Sonja Skalet, Jennifer Kremer, Hao Li, Elisabeth K. M. Mack

Publikováno v: Cells, Vol 11, Iss 22, p 3527 (2022)

Reduction of insulin/insulin-like growth factor 1 (IGF1) signaling (IIS) promotes longevity across species. In the nematode Caenorhabditis elegans, ablation of germline stem cells (GSCs) and activity changes of the conserved signaling mediators unc-4

Externí odkaz: https://doaj.org/article/d912b26fa9b0409382be19a67f0eda6b

Expression of β-1,4-galactosyltransferases during Aging in Caenorhabditis elegans

Autor: Cornelia Brendel, Jennifer Kremer, Elisabeth Mack, Hildegard I.D. Mack

Publikováno v: Gerontology. 66:571-581

Background: Altered plasma activity of β-1,4-galac­tosyl­transferases (B4GALTs) is a novel candidate biomarker of human aging. B4GALT1 is assumed to be largely responsible for this activity increase, but how it modulates the aging process is uncle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::47b3f63457d643074bb8a2a2f62d2aff
https://doi.org/10.1159/000510722

Cloning and characterization of a novel druggable fusion kinase in acute myeloid leukemia

Autor: Sonja K. Hühn, Lutz B. Jehn, Gert Bange, Christian Michel, Ying Wang, André Marquardt, Clara Simon, Elisabeth Mack, Christopher-Nils Mais, Lea V. Fritz, Andreas Neubauer, Andreas Burchert, Ellen Wollmer, Jennifer Kremer, Kristina Sohlbach, Cornelia Brendel, Claudia Haferlach, Sabrina Inselmann

Publikováno v: Haematologica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e65abada20c982829846b71fe1f0c7
https://doi.org/10.3324/haematol.2019.237818

Cell-free prototyping of AND-logic gates based on heterogeneous RNA activators

Autor: Jennifer Kremer, H. Ulrich Göringer, Heinz Koeppl, Marc Vogel, François-Xavier Lehr, Maleen Hanst, Beatrix Suess

Publikováno v: ACS Synthetic Biology

RNA-based devices controlling gene expression bear great promise for synthetic biology, as they offer many advantages like short response times and light metabolic burden compared to protein-circuits. However, little work has been done regarding thei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb307f097f254fa75e345914bf73ec0b
https://doi.org/10.1101/661561

Combined Focused Next-Generation Sequencing Assays to Guide Precision Oncology in Solid Tumors: A Retrospective Analysis from an Institutional Molecular Tumor Board.

Autor: Tarawneh, Thomas S.¹ (AUTHOR), Rodepeter, Fiona R.² (AUTHOR), Teply-Szymanski, Julia² (AUTHOR), Ross, Petra¹ (AUTHOR), Koch, Vera^1,3 (AUTHOR), Thölken, Clemens³ (AUTHOR), Schäfer, Jonas A.¹ (AUTHOR), Gremke, Niklas⁴ (AUTHOR), Mack, Hildegard I. D.¹ (AUTHOR), Gold, Judith¹ (AUTHOR), Riera-Knorrenschild, Jorge¹ (AUTHOR), Wilhelm, Christian¹ (AUTHOR), Rinke, Anja⁵ (AUTHOR), Middeke, Martin⁶ (AUTHOR), Klemmer, Andreas⁷ (AUTHOR), Romey, Marcel² (AUTHOR), Hattesohl, Akira² (AUTHOR), Jesinghaus, Moritz² (AUTHOR), Görg, Christian^1,5 (AUTHOR), Figiel, Jens⁸ (AUTHOR)

Publikováno v: Cancers. Sep2022, Vol. 14 Issue 18, pN.PAG-N.PAG. 17p.