Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jennifer K. Saucier-Sawyer"'
Autor:
Jeremiah A. Johnson, DeborahJ. C. Ehrlich, MatthewR. Golder, Allison M. Neenan, Peter Blume-Jensen, James C. Ackley, William K. Dahlberg, Kyriakos D. Economides, Jennifer K. Saucier-Sawyer, Lawrence A. Reiter, Paul W. Kopesky, Elisa de Stanchina, Olga Burenkova, David J. Turnquist, Jannik N. Andersen, Sattanathan Paramasivan, Jenny Liu, Bhavatarini Vangamudi, Sung Jin Huh, Nolan M. Gallagher, Samantha W. Brady, Michael J. Jessel, Donald E. Chickering, Peyton Shieh, Farrukh Vohidov, Joelle Baddour, Julie Kim, Michail Shipitsin, Hung V.-T. Nguyen, Gaurab Kc
Prodrugs engineered for preferential activation in diseased versus normal tissues offer immense potential to improve the therapeutic index of preclinical and clinical-stage active pharmaceutical ingredients that either cannot be developed otherwise o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4231b129eb3966639444cef3e553ca
https://doi.org/10.26434/chemrxiv.13241966.v1
https://doi.org/10.26434/chemrxiv.13241966.v1
Autor:
Sattanathan Paramasivan, Kyriakos D. Economides, Deborah C. Ehrlich, Eric J. Held, Joelle Baddour, Peter Blume-Jensen, Matthew R. Golder, Allison M. Neenan, Jeremiah A. Johnson, Samantha W. Brady, James C. Ackley, Jennifer K. Saucier-Sawyer, Bhavatarini Vangamudi, Farrukh Vohidov, Paul W. Kopesky, Sung Jin Huh, Hung V.-T. Nguyen, Donald E. Chickering, Michail Shipitsin, Jannik N. Andersen, Jenny Liu, Lawrence A. Reiter
Publikováno v:
Nature biomedical engineering
At present there are no drugs for the treatment of chronic liver fibrosis that have been approved by the Food and Drug Administration of the United States. Telmisartan, a small-molecule antihypertensive drug, displays antifibrotic activity, but its c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e98eadcb9d6da5cc80f3eab8653dfa20
https://pubmed.ncbi.nlm.nih.gov/31015683
https://pubmed.ncbi.nlm.nih.gov/31015683
Autor:
Jennifer K. Saucier-Sawyer, Eric Song, Elias Quijano, W. Mark Saltzman, Yang Deng, Andrew J. Sawyer, Alice Gaudin, Young-Eun Seo, Anita Huttner
Publikováno v:
Journal of Controlled Release. 232:103-112
Glioblastoma multiforme (GBM) is a fatal brain tumor characterized by infiltration beyond the margins of the main tumor mass and local recurrence after surgery. The blood-brain barrier (BBB) poses the most significant hurdle to brain tumor treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::611337c07f6e5625439e7573baf4ea86
https://doi.org/10.1016/j.jconrel.2016.04.006
https://doi.org/10.1016/j.jconrel.2016.04.006
Autor:
W. Mark Saltzman, Jennifer K. Saucier-Sawyer, Junwei Zhang, Young-Eun Seo, Yang Deng, Elias Quijano, Christopher J. Cheng
Publikováno v:
Journal of Drug Targeting. 23:736-749
Delivery of therapeutic agents to the central nervous system is a significant challenge, hindering progress in the treatment of diseases such as glioblastoma. Due to the presence of the blood-brain barrier (BBB), therapeutic agents do not readily tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15fe66d06588d1fb29a524eb25fe9339
https://doi.org/10.3109/1061186x.2015.1065833
https://doi.org/10.3109/1061186x.2015.1065833
Publikováno v:
Nature Reviews Drug Discovery. 14:239-247
The primary goal of nanomedicine is to improve clinical outcomes. To this end, targeted nanoparticles are engineered to reduce non-productive distribution while improving diagnostic and therapeutic efficacy. Paradoxically, as this field has matured,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::936a7690fd62ad7316b909874fbe3058
https://doi.org/10.1038/nrd4503
https://doi.org/10.1038/nrd4503
Autor:
Alice Gaudin, Jennifer K. Saucier-Sawyer, Amanda King, Eric Song, Didier Desmaële, W. Mark Saltzman, Patrick Couvreur, Ranjit S. Bindra
Publikováno v:
Biomaterials. 105
New treatments for glioblastoma multiforme (GBM) are desperately needed, as GBM prognosis remains poor, mainly due to treatment resistance, poor distribution of therapeutics in the tumor tissue, and fast metabolism of chemotherapeutic drugs in the br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::985545784e06f5080b877c15a7e26a08
https://pubmed.ncbi.nlm.nih.gov/27521616
https://pubmed.ncbi.nlm.nih.gov/27521616
Autor:
Jennifer K. Saucier-Sawyer, Richard L. Edelson, Douglas Hanlon, W. Mark Saltzman, Clarence T. Sasaki, Shashi Prasad, Virginia Cody, Martin A. Birchall
Publikováno v:
Nanomedicine: Nanotechnology, Biology and Medicine. 7:1-10
Encapsulation of tumor-associated antigens in polymer nanoparticles (NP) is a promising approach to enhance efficiency of antigen delivery for anti-tumor vaccines. Head and neck squamous carcinoma (HNSCC) cell lines were initially used to generate tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91964770297abaaf4b67cf19fa257fbb
https://doi.org/10.1016/j.nano.2010.07.002
https://doi.org/10.1016/j.nano.2010.07.002
Autor:
Carmen J. Booth, Jennifer K. Saucier-Sawyer, Joseph M. Piepmeier, W. Mark Saltzman, Andrew J. Sawyer, Jie Liu, Toral R. Patel
Publikováno v:
Drug Delivery and Translational Research. 1:34-42
Direct delivery of chemotherapy agents to the brain via degradable polymer delivery systems—such as Gliadel®—is a clinically proven method for treatment of glioblastoma multiforme, but there are important limitations with the current technology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff842f6322eab0f8f921b4b0aa6c2019
https://doi.org/10.1007/s13346-010-0001-3
https://doi.org/10.1007/s13346-010-0001-3
Autor:
Sattanathan Paramasivan, Eric J. Held, Hung V.-T. Nguyen, Jennifer K. Saucier-Sawyer, James C. Ackley, Donald E. Chickering, Jeremiah A. Johnson, Matthew R. Golder, Deborah C. Ehrlich, Paul W. Kopesky, Peter Blume-Jensen, Joelle Baddour, Jannik N. Andersen, Sung Jin Huh, Michail Shipitsin, Allison M. Neenan, Jenny Liu, Lawrence A. Reiter, Samantha W. Brady, Farrukh Vohidov, Bhavatarini Vangamudi, Kyriakos D. Economides
Publikováno v:
Nature Biomedical Engineering. 2:707-707
In the version of this Article originally published, the author Peter Blume-Jensen was not denoted as a corresponding author; this has now been amended and the author’s email address has been added. The ‘Correspondence and requests for materials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc5a5b00c05939bab05d3ac76668806d
https://doi.org/10.1038/s41551-018-0299-6
https://doi.org/10.1038/s41551-018-0299-6
Publikováno v:
Molecular Pharmaceutics. 4:47-57
Encapsulation of tumor-associated antigens (TAA) in polymer nanoparticles is a promising approach to increasing the efficiency of antigen (Ag) delivery for antitumor vaccines. We optimized a polymer preparation method to deliver both defined tumor-as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afabb22b1ee71aaa5e9f9b4c0a66d2f7
https://doi.org/10.1021/mp060107e
https://doi.org/10.1021/mp060107e