Zobrazeno 1 - 10
of 227
pro vyhledávání: '"Jennifer K. Richer"'
Autor:
Anthony D. Elias, Nicole S. Spoelstra, Alyse W. Staley, Sharon Sams, Lyndsey S. Crump, Gregory A. Vidal, Virginia F. Borges, Peter Kabos, Jennifer R. Diamond, Elena Shagisultanova, Anosheh Afghahi, Jose Mayordomo, Tessa McSpadden, Gloria Crawford, Angelo D’Alessandro, Kathryn L. Zolman, Adrie van Bokhoven, Yonghua Zhuang, Rosa I. Gallagher, Julia D. Wulfkuhle, Emanuel F. Petricoin III, Dexiang Gao, Jennifer K. Richer
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-10 (2023)
Abstract This clinical trial combined fulvestrant with the anti-androgen enzalutamide in women with metastatic ER+/HER2− breast cancer (BC). Eligible patients were women with ECOG 0–2, ER+/HER2− measurable or evaluable metastatic BC. Prior fulv
Externí odkaz:
https://doaj.org/article/ad0c82b5d82a4e81a6170a0a923d1435
Autor:
Zheqi Li, Nicole S. Spoelstra, Matthew J. Sikora, Sharon B. Sams, Anthony Elias, Jennifer K. Richer, Adrian V. Lee, Steffi Oesterreich
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-13 (2022)
Abstract Both TP53 and ESR1 mutations occur frequently in estrogen receptor positive (ER+) metastatic breast cancers (MBC) and their distinct roles in breast cancer tumorigenesis and progression are well appreciated. Recent clinical studies discovere
Externí odkaz:
https://doaj.org/article/03cb6e6b73364a1baa4c00765d7de9ff
Autor:
Zheqi Li, Olivia McGinn, Yang Wu, Amir Bahreini, Nolan M. Priedigkeit, Kai Ding, Sayali Onkar, Caleb Lampenfeld, Carol A. Sartorius, Lori Miller, Margaret Rosenzweig, Ofir Cohen, Nikhil Wagle, Jennifer K. Richer, William J. Muller, Laki Buluwela, Simak Ali, Tullia C. Bruno, Dario A. A. Vignali, Yusi Fang, Li Zhu, George C. Tseng, Jason Gertz, Jennifer M. Atkinson, Adrian V. Lee, Steffi Oesterreich
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Mutations of ESR1, the gene encoding the estrogen receptor alpha, are associated with acquired resistance to therapy in luminalbreast cancer. Here the authors show that ESR1 mutant tumors gain basal-like features with increased expression of basal cy
Externí odkaz:
https://doaj.org/article/3ce70acd6e2e4c66a89d08122c1ec702
Autor:
Lisa Welter, Serena Zheng, Sonia Maryam Setayesh, Michael Morikado, Arushi Agrawal, Rafael Nevarez, Amin Naghdloo, Milind Pore, Nikki Higa, Anand Kolatkar, Jana-Aletta Thiele, Priyanka Sharma, Halle C. F. Moore, Jennifer K. Richer, Anthony Elias, Kenneth J. Pienta, Amado J. Zurita, Mitchell E. Gross, Stephanie N. Shishido, James Hicks, Carmen Ruiz Velasco, Peter Kuhn
Publikováno v:
Cancers, Vol 15, Iss 15, p 3949 (2023)
Bi-directional crosstalk between the tumor and the tumor microenvironment (TME) has been shown to increase the rate of tumor evolution and to play a key role in neoplastic progression, therapeutic resistance, and a patient’s overall survival. Here,
Externí odkaz:
https://doaj.org/article/f1d7b9cd99644176a638d9de79e01ecb
Autor:
Toru Hanamura, Jessica L. Christenson, Kathleen I. O’Neill, Emmanuel Rosas, Nicole S. Spoelstra, Michelle M. Williams, Jennifer K. Richer
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-15 (2021)
Abstract Purpose Accumulating evidence has attracted attention to the androgen receptor (AR) as a biomarker and therapeutic target in breast cancer. We hypothesized that AR activity within the tumor has clinical implications and investigated whether
Externí odkaz:
https://doaj.org/article/0371be8231394e019312e132cfe5dbce
Autor:
Michelle M. Williams, Jessica L. Christenson, Kathleen I. O’Neill, Sabrina A. Hafeez, Claire L. Ihle, Nicole S. Spoelstra, Jill E. Slansky, Jennifer K. Richer
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-13 (2021)
Abstract Many immune suppressive mechanisms utilized by triple negative breast cancer (TNBC) are regulated by oncogenic epithelial-to-mesenchymal transition (EMT). How TNBC EMT impacts innate immune cells is not fully understood. To determine how TNB
Externí odkaz:
https://doaj.org/article/60e89acc1885465fafd6cd0d4bea2bf5
Autor:
Natalia B. Fernández, Sofía M. Sosa, Justin T. Roberts, María S. Recouvreux, Luciana Rocha-Viegas, Jessica L. Christenson, Nicole S. Spoelstra, Facundo L. Couto, Ana R. Raimondi, Jennifer K. Richer, Natalia Rubinstein
Publikováno v:
Cells, Vol 12, Iss 3, p 444 (2023)
Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype for which no effective targeted therapies are available. Growing evidence suggests that chemotherapy-resistant cancer cells with stem-like properties (CSC) may repopulate the
Externí odkaz:
https://doaj.org/article/82ee5a10864e493fb5f423a04c49e88e
Autor:
Faye A. Camp, Tonya M. Brunetti, Michelle M. Williams, Jessica L. Christenson, Varsha Sreekanth, James C. Costello, Zachary L. Z. Hay, Ross M. Kedl, Jennifer K. Richer, Jill E. Slansky
Publikováno v:
Cancers, Vol 14, Iss 18, p 4397 (2022)
Antigenic differences formed by alterations in gene expression and alternative splicing are predicted in breast cancer cells undergoing epithelial to mesenchymal transition (EMT) and the reverse plasticity known as MET. How these antigenic difference
Externí odkaz:
https://doaj.org/article/7b708c1718cc43708f7240b577a154ea
Autor:
Lindsay J. Wheeler, Zachary L. Watson, Lubna Qamar, Tomomi M. Yamamoto, Brandon T. Sawyer, Kelly D. Sullivan, Santosh Khanal, Molishree Joshi, Veronique Ferchaud-Roucher, Harry Smith, Lauren A. Vanderlinden, Sky W. Brubaker, Cecilia M. Caino, Hyunmin Kim, Joaquin M. Espinosa, Jennifer K. Richer, Benjamin G. Bitler
Publikováno v:
iScience, Vol 19, Iss , Pp 474-491 (2019)
Summary: High-grade serous ovarian cancers (HGSOCs) arise from exfoliation of transformed cells from the fallopian tube, indicating that survival in suspension, and potentially escape from anoikis, is required for dissemination. We report here the re
Externí odkaz:
https://doaj.org/article/d7cae58c70cf4b989ef74c7cfa5a6c7f
Autor:
Kathleen I. O’Neill, Li-Wei Kuo, Michelle M. Williams, Hanne Lind, Lyndsey S. Crump, Nia G. Hammond, Nicole S. Spoelstra, M. Cecilia Caino, Jennifer K. Richer
Publikováno v:
Cancers, Vol 14, Iss 14, p 3543 (2022)
Triple-negative breast cancer (TNBC) often undergoes at least partial epithelial-to-mesenchymal transition (EMT) to facilitate metastasis. Identifying EMT-associated characteristics can reveal novel dependencies that may serve as therapeutic vulnerab
Externí odkaz:
https://doaj.org/article/773f4b7fb82749dbb78c461246ac43e8