Výsledky vyhledávání - "Jennifer K. Ng"

Akademický článek

Modifying ligand-induced and constitutive signaling of the human 5-HT4 receptor.

Autor: Wei Chun Chang, Jennifer K Ng, Trieu Nguyen, Lucie Pellissier, Sylvie Claeysen, Edward C Hsiao, Bruce R Conklin

Publikováno v: PLoS ONE, Vol 2, Iss 12, p e1317 (2007)

G protein-coupled receptors (GPCRs) signal through a limited number of G-protein pathways and play crucial roles in many biological processes. Studies of their in vivo functions have been hampered by the molecular and functional diversity of GPCRs an

Externí odkaz: https://doaj.org/article/67b33aa5d0ed4ddca830fafbf90dd728

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Daptomycin Dosing Based on Ideal Body Weight versus Actual Body Weight: Comparison of Clinical Outcomes

Autor: Jeffrey T. Fish, Lucas T Schulz, Barry C. Fox, Kevin A. Buhr, Warren E. Rose, Jennifer K. Ng, David R. Andes

Publikováno v: Antimicrobial Agents and Chemotherapy. 58:88-93

Daptomycin use at our institution changed to ideal body weight dosing based on a published analysis of pharmacokinetic-pharmacodynamic efficacy target attainment, bacterial ecology, and a desire to reduce drug toxicity. The current study compared out

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4126a1776d4c8a5b3537953d2976b402
https://doi.org/10.1128/aac.01018-13

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Man1, an inner nuclear membrane protein, regulates vascular remodeling by modulating transforming growth factor β signaling

Autor: Masanori Taira, Stephen G. Young, Jennifer K. Ng, Akihiko Ishimura, Shin-Ichi Osada

Publikováno v: Development. 133:3919-3928

A growing number of integral inner nuclear membrane (INM) proteins have been implicated in diverse cellular functions. Man1, an INM protein, has recently been shown to regulate transforming growth factor (Tgf) βsuperfamily signaling by interacting w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d8a4be79d7be832ef404b2f074896d4
https://doi.org/10.1242/dev.02538

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Prelamin A and lamin A appear to be dispensable in the nuclear lamina

Autor: Sandy Y. Chang, Colin L. Stewart, C. Frank Bennett, Richard T. Lee, Loren G. Fong, Stephen G. Young, Shao H. Yang, Xin Qiao, Martin O. Bergo, Margarita Meta, Jan Lammerding, Timothy A. Vickers, Nathan Coté, Stephanie R. Young, Jennifer K. Ng, Bryant J. Gavino

Publikováno v: Journal of Clinical Investigation. 116:743-752

Lamin A and lamin C, both products of Lmna, are key components of the nuclear lamina. In the mouse, a deficiency in both lamin A and lamin C leads to slow growth, muscle weakness, and death by 6 weeks of age. Fibroblasts deficient in lamins A and C c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ee56ad79d0c20b167405ab765903fc2
https://doi.org/10.1172/jci27125

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The limb identity geneTbx5promotes limb initiation by interacting withWnt2bandFgf10

Autor: Concepcion Rodriguez Esteban, Jennifer K. Ng, Joaquín Rodríguez-León, Mark C. Fishman, Tohru Itoh, Deborah M. Garrity, Dirk Büscher, Juan Carlos Izpisua Belmonte, Christopher M. Koth, Yasuhiko Kawakami, Angel Raya

Publikováno v: Development. 129:5161-5170

A major gap in our knowledge of development is how the growth and identity of tissues and organs are linked during embryogenesis. The vertebrate limb is one of the best models to study these processes. Combining mutant analyses with gain- and loss-of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1661ebcfd3bb7a8136af9537f8c5bcb
https://doi.org/10.1242/dev.129.22.5161

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Endothelial ephrin-B2 is essential for arterial vasodilation in mice

Autor: Jennifer K. Ng, Rong Wang, Asmita Jina, Weiya Jiang, Yuankai Lin

Publikováno v: Microcirculation (New York, N.Y. : 1994). 21(7)

Objective The cell surface protein ephrin-B2 is expressed in arterial and not venous ECs throughout development and adulthood. Endothelial ephrin-B2 is required for vascular development and angiogenesis, but its role in established arteries is curren

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f0499a1200192ceeab49af73decd86
https://pubmed.ncbi.nlm.nih.gov/24673722

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Transgenic Mice Expressing Human ApoB95 and ApoB97

Autor: Jere P. Segrest, Stacy Taylor, Sally P.A. McCormick, Stephen G. Young, Candace M. Cham, Santica M. Marcovina, Robert E. Hammer, Jennifer K. Ng

Publikováno v: Journal of Biological Chemistry. 272:23616-23622

The structural features of apolipoprotein (apo) B that are important for its covalent linkage to apo(a) to form lipoprotein(a) (Lp(a)) are incompletely understood. Although apoB100 cysteine 4326 is required for the disulfide linkage with apo(a), othe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ef63295b3342ffd45532f5048e99727
https://doi.org/10.1074/jbc.272.38.23616

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Transgenic Mice That Overexpress Mouse Apolipoprotein B

Autor: David S. Grass, Vincenzo Pierotti, Sally P.A. McCormick, Stephen G. Young, Andrew J. Connolly, Jan Borén, Laura M. Flynn, Murielle M. Véniant, Jennifer K. Ng

Publikováno v: Journal of Biological Chemistry. 271:11963-11970

An 87-kilobase (kb) P1 bacteriophage clone (p649) spanning the mouse apolipoprotein (apo) B gene was used to generate transgenic mice that express high levels of mouse apoB. Plasma levels of apoB, low density lipoprotein cholesterol, and low density

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::22c2f1f8f0a3e63b418e144335f8b29f
https://doi.org/10.1074/jbc.271.20.11963

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Constitutively active endothelial Notch4 causes lung arteriovenous shunts in mice

Autor: Rong Wang, Xiaoqing Wu, Doug Miniati, Eric B. Jelin, Jianfeng Wu, Timothy R. Carlson, Mark R. Looney, Jennifer K. Ng

Publikováno v: American journal of physiology. Lung cellular and molecular physiology. 298(2)

Lung arteriovenous (AV) shunts or malformations cause significant morbidity and mortality in several distinct clinical syndromes. For most patients with lung AV shunts, there is still no optimal treatment. The underlying molecular and cellular etiolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5e8bdbf75a177d0c2de76843b25687
https://pubmed.ncbi.nlm.nih.gov/19933399

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Modifying ligand-induced and constitutive signaling of the human 5-HT4 receptor

Autor: Trieu Nguyen, Sylvie Claeysen, Wei Chun Chang, Edward C. Hsiao, Jennifer K. Ng, Lucie P. Pellissier, Bruce R. Conklin

Publikováno v: PLoS ONE, Vol 2, Iss 12, p e1317 (2007)
PLoS ONE
PLoS ONE, Public Library of Science, 2007, 2 (12), pp.e1317. ⟨10.1371/journal.pone.0001317⟩
PloS one, vol 2, iss 12
Plos One 12 (2), 1-12. (2007)

International audience; G protein-coupled receptors (GPCRs) signal through a limited number of G-protein pathways and play crucial roles in many biological processes. Studies of their in vivo functions have been hampered by the molecular and function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e62bf550fe2c912b27bf945091714b
http://europepmc.org/articles/PMC2267039?pdf=render

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